Implementation of Sleep and Circadian Science: Recommendations from the Sleep Research Society and National Institutes of Health Workshop
(Source: Sleep)
Source: Sleep - December 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Bruxism-Tooth Grinding Prevalence, Characteristics and Familial Aggregation: A Large Cross-Sectional Survey and Polysomnographic Validation
Conclusions:Our results support the heritability of SB-tooth grinding and that sleep quality and pain are concomitant in a significant number of SB subjects.Citation:Khoury S, Carra MC, Huynh N, Montplaisir J, Lavigne GJ. Sleep bruxism-tooth grinding prevalence, characteristics and familial aggregation: a large cross-sectional survey and polysomnographic validation.SLEEP 2016;39(11):2049–2056. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid A β42 Levels in Cognitively Normal Elderly
Conclusions:In cognitively normal elderly, reduced and fragmented SWS is associated with increases in CSF Aβ42, suggesting that disturbed sleep might drive an increase in soluble brain Aβ levels prior to amyloid deposition.Citation:Varga AW, Wohlleber ME, Giménez S, Romero S, Alonso JF, Ducca EL, Kam K, Lewis C, Tanzi EB, Tweardy S, Kishi A, Parekh A, Fischer E, Gumb T, Alcolea D, Fortea J, Lleó A, Blennow K, Zetterberg H, Mosconi L, Glodzik L, Pirraglia E, Burschtin OE, de Leon MJ, Rapoport DM, Lu S, Ayappa I, Osorio RS. Reduced slow-wave sleep is associated with high cerebrospinal fluid Aβ42 ...
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection
Conclusions:These results suggest that sleep induced by remote preconditioning is both sufficient and necessary for its neuroprotective effects on stroke outcome.Citation:Brager AJ, Yang T, Ehlen JC, Simon RP, Meller R, Paul KN. Sleep is critical for remote preconditioning-induced neuroprotection.SLEEP 2016;39(11):2033–2040. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Fragmentation of Rapid Eye Movement and Nonrapid Eye Movement Sleep without Total Sleep Loss Impairs Hippocampus-Dependent Fear Memory Consolidation
Conclusions:Our findings in an intact animal model, in which sleep deprivation is not a confounding factor, support the hypothesis that the stereotypic sequence and duration of sleep stages play a specific role in long-term hippocampus-dependent fear memory consolidation.Citation:Lee ML, Katsuyama AM, Duge LS, Sriram C, Krushelnytskyy M, Kim JJ, de la Iglesia HO. Fragmentation of rapid eye movement and nonrapid eye movement sleep without total sleep loss impairs hippocampus-dependent fear memory consolidation.SLEEP 2016;39(11):2021–2031. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Duration and Overweight/Obesity in Preschool-Aged Children: A Prospective Study of up to 48,922 Children of the Jiaxing Birth Cohort
Conclusions:Both short and overlong sleep duration are associated with a higher risk of overweight/obesity in preschool-aged children. Optimizing sleep duration may be an important modifiable intervention for overweight and obesity.Citation:Wang F, Liu H, Wan Y, Li J, Chen Y, Zheng J, Huang T, Li D. Sleep duration and overweight/obesity in preschool-aged children: a prospective study of up to 48,922 children of the Jiaxing birth cohort.SLEEP 2016;39(11):2013–2019. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Effect of Adenotonsillectomy on Parent-Reported Sleepiness in Children with Obstructive Sleep Apnea
Conclusions:Sleepiness assessed by parent report was prevalent; improved more after eAT than after WWSC; and was not strongly predicted by sleep disturbances identified by PSG.Clinical Trial Registration:Childhood Adenotonsillectomy Study for Children with OSA (CHAT). ClinicalTrials.gov Identifier #NCT00560859.Citation:Paruthi S, Buchanan P, Weng J, Chervin RD, Mitchell RB, Dore-Stites D, Sadhwani A, Katz ES, Bent J, Rosen CL, Redline S, Marcus CL. Effect of adenotonsillectomy on parent-reported sleepiness in children with obstructive sleep apnea.SLEEP 2016;39(11):2005–2012. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Clusters of Insomnia Disorder: An Exploratory Cluster Analysis of Objective Sleep Parameters Reveals Differences in Neurocognitive Functioning, Quantitative EEG, and Heart Rate Variability
Conclusions:Two insomnia clusters derived from cluster analysis differ in sleep onset HRV. Preliminary data suggest evidence for three clusters in insomnia with differences for sustained attention and sleep-onsetq-EEG.Clinical Trial Registration:Insomnia 100 sleep study: Australia New Zealand Clinical Trials Registry (ANZCTR) identification number 12612000049875. URL:https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=347742.Citation:Miller CB, Bartlett DJ, Mullins AE, Dodds KL, Gordon CJ, Kyle SD, Kim JW, D'Rozario AL, Lee RS, Comas M, Marshall NS, Yee BJ, Espie CA, Grunstein RR. Clusters of Insomnia Disorder...
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
A Longitudinal Twin and Sibling Study of Associations between Insomnia and Depression Symptoms in Young Adults
Conclusions:While genetic effects play a modest role in insomnia and depression symptoms separately, they appear to play a more central role in concurrent and longitudinal associations between these phenotypes. This should be acknowledged in theories explaining these common associations.Citation:Gregory AM, Rijsdijk FV, Eley TC, Buysse DJ, Schneider MN, Parsons M, Barclay NL. A longitudinal twin and sibling study of associations between insomnia and depression symptoms in young adults.SLEEP 2016;39(11):1985–1992. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
The Combination of Supplemental Oxygen and a Hypnotic Markedly Improves Obstructive Sleep Apnea in Patients with a Mild to Moderate Upper Airway Collapsibility
Conclusions:The combination of lowering loop gain and raising the arousal threshold is an effective therapy in patients whose anatomy is not severely compromised. Our work demonstrates that combining therapies that target multiple traits can resolve OSA in selected individuals.Clinical Trial Registration:ClinicalTrials.gov, ID: NCT01633827Citation:Edwards BA, Sands SA, Owens RL, Eckert DJ, Landry S, White DP, Malhotra A, Wellman A. The combination of supplemental oxygen and a hypnotic markedly improves obstructive sleep apnea in patients with a mild to moderate upper airway collapsibility.SLEEP 2016;39(11):1973–1983. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Effective Apnea-Hypopnea Index ( & ldquo;Effective AHI & rdquo;): A New Measure of Effectiveness for Positive Airway Pressure Therapy
Conclusions:Significant disease burden, as objectively measured by the Effective AHI, may still exist in many patients with severe OSA in whom PAP therapy is not utilized for the entire sleep period. The WP is a reasonably accurate device to measure the Effective AHI.Citation:Boyd SB, Upender R, Walters AS, Goodpaster L, Stanley JJ, Wang L, Chandrasekhar R. Effective apnea-hypopnea index (“Effective AHI”): a new measure of effectiveness for positive airway pressure therapy.SLEEP 2016;39(11):1961–1972. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Aberrant Food Choices after Satiation in Human Orexin-Deficient Narcolepsy Type 1
Conclusions:We show that the manipulation of food-specific satiety has reduced effects on food choices and caloric intake in narcolepsy type 1 patients. These mechanisms may contribute to their obesity, and suggest an important functional role for orexin in human eating behavior.Clinical Trials Registration:Study registered at Netherlands Trial Register. URL:www.trialregister.nl. Trial ID: NTR4508.Citation:van Holst RJ, van der Cruijsen L, van Mierlo P, Lammers GJ, Cools R, Overeem S, Aarts E. Aberrant food choices after satiation in human orexindeficient narcolepsy type 1.SLEEP 2016;39(11):1951–1959. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Core Body and Skin Temperature in Type 1 Narcolepsy in Daily Life; Effects of Sodium Oxybate and Prediction of Sleep Attacks
Conclusions:This ambulatory study demonstrates that daytime sleep attacks were preceded by clear changes in distal skin temperature and DPG. Furthermore, changes in core body and skin temperature in narcolepsy, previously only studied in laboratory settings, were partially confirmed. Treatment with SXB resulted in a normalisation of the core body temperature profile. Future studies should explore whether predictive temperature changes can be used to signal or even prevent sleep attacks.Citation:van der Heide A, Werth E, Donjacour CE, Reijntjes RH, Lammers GJ, Van Someren EJ, Baumann CR, Fronczek R. Core body and skin tempe...
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Duration and Quality in Relation to Autonomic Nervous System Measures: The Multi-Ethnic Study of Atherosclerosis (MESA)
Conclusions:Short sleep duration, low sleep efficiency, and insomnia combined with short sleep duration were associated with markers of autonomic tone that indicate lower levels of cardiac parasympathetic (vagal) tone and/or higher levels of sympathetic tone.Citation:Castro-Diehl C, Roux AV, Redline S, Seeman T, McKinley P, Sloan R, Shea S. Sleep duration and quality in relation to autonomic nervous system measures: the Multi-Ethnic Study of Atherosclerosis (MESA).SLEEP 2016;39(11):1927–1940. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
Sleep Duration and Diabetes Risk in American Indian and Alaska Native Participants of a Lifestyle Intervention Project
Conclusions:Short sleep duration, but not long duration, was significantly associated with increased diabetes risk and less weight loss among AI/ANs in a lifestyle intervention. Further exploration of the complex factors underlying short sleep duration is warranted.Citation:Nuyujukian DS, Beals J, Huang H, Johnson A, Bullock A, Manson SM, Jiang L, Special Diabetes Program for Indians Diabetes Prevention Demonstration Project. Sleep duration and diabetes risk in American Indian and Alaska native participants of a lifestyle intervention project.SLEEP 2016;39(11):1919–1926. (Source: Sleep)
Source: Sleep - November 1, 2016 Category: Sleep Medicine Source Type: research
