The Benefits of Targeted Memory Reactivation for Consolidation in Sleep are Contingent on Memory Accuracy and Direct Cue-Memory Associations
Conclusions:TMR provides the greatest benefit to memories recalled with a low degree of accuracy prior to sleep. The memory benefits of TMR may also be contingent on direct cue-memory associations.Citation:Cairney SA, Lindsay S, Sobczak JM, Paller KA, Gaskell MG. The benefits of targeted memory reactivation for consolidation in sleep are contingent on memory accuracy and direct cue-memory associations. SLEEP 2016;39(5):1139–1150. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
K-Complexes: Interaction between the Central and Autonomic Nervous Systems during Sleep
Conclusions:The strict dependency observed between KCs and cardiac control indicates a potential role of KCs in modulating the cardiovascular system during sleep. Sex differences in the KC-cardiac response indicate the sensitivity of this measure in capturing sex differences in cardiac regulatory physiology.Citation:de Zambotti M, Willoughby AR, Franzen PL, Clark DB, Baker FC. K-complexes: interaction between the central and autonomic nervous systems during sleep. SLEEP 2016;39(5):1129–1137. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults
Conclusions:Among cognitively normal older adults, sleep durations of < 7 h and > 7 h may increase the rate of subsequent frontotemporal gray matter atrophy. Additional studies, including those that use objective sleep measures and investigate mechanisms linking sleep duration to gray matter loss, are needed.Citation:Spira AP, Gonzalez CE, Venkatraman VK, Wu MN, Pacheco J, Simonsick EM, Ferrucci L, Resnick SM. Sleep duration and subsequent cortical thinning in cognitively normal older adults. SLEEP 2016;39(5):1121–1128. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Sleep and Health Resilience Metrics in a Large Military Cohort
Conclusions:Poor sleep is a detriment to service members' health and readiness. Leadership should redouble efforts to emphasize the importance of healthy sleep among military service members, and future research should focus on the efficacy of interventions to promote healthy sleep and resilience in this population.Commentary:A commentary on this article appears in this issue on page 963.Citation:Seelig AD, Jacobson IG, Donoho CJ, Trone DW, Crum-Cianflone NF, Balkin TJ. Sleep and health resilience metrics in a large military cohort. SLEEP 2016;39(5):1111–1120. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Inter-individual Differences in the Effects of Aircraft Noise on Sleep Fragmentation
Conclusions:It will be important to identify those at higher risk for noise induced sleep disturbance. Furthermore, the custom to base noise policy and legislation on average responses should be re-assessed based on these findings.Citation:McGuire S, Müller U, Elmenhorst EM, Basner M. Inter-individual differences in the effects of aircraft noise on sleep fragmentation. SLEEP 2016;39(5):1107–1110. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Localizing Effects of Leptin on Upper Airway and Respiratory Control during Sleep
Conclusions:Leptin relieves upper airway obstruction in sleep apnea by activating the forebrain, possibly in the dorsomedial hypothalamus. In contrast, leptin upregulates ventilatory control through hindbrain sites of action, possibly in the nucleus of the solitary tract.Citation:Yao Q, Pho H, Kirkness J, Ladenheim EE, Bi S, Moran TH, Fuller DD, Schwartz AR, Polotsky VY. Localizing effects of leptin on upper airway and respiratory control during sleep. SLEEP 2016;39(5):1097–1106. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila
Conclusions:Our data show that rebound sleep following thermogenetic sleep deprivation can be genetically separated from sleep at baseline. This suggests that genetically controlled mechanisms of sleep regulation not manifest under undisturbed conditions contribute to sleep rebound following thermogenetic sleep deprivation.Citation:Dubowy C, Moravcevic K, Yue Z, Wan JY, Van Dongen HP, Sehgal A. Genetic dissociation of daily sleep and sleep following thermogenetic sleep deprivation in Drosophila. SLEEP 2016;39(5):1083–1095. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Responses in Rat Core Auditory Cortex are Preserved during Sleep Spindle Oscillations
Conclusions:Responses in core auditory cortex are well preserved regardless of sleep spindles recorded in that area, suggesting that thalamocortical sensory relay remains functional during sleep spindles, and that sensory disconnection in sleep is mediated by other mechanisms.Citation:Sela Y, Vyazovskiy VV, Cirelli C, Tononi G, Nir Y. Responses in rat core auditory cortex are preserved during sleep spindle oscillations. SLEEP 2016;39(5):1069–1082. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
The Relationship between Sleep Quality and Brain Amyloid Burden
Conclusions:Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.Citation:Brown BM, Rainey-Smith SR, Villemagne VL, Weinborn M, Bucks RS, Sohrabi HR, Laws SM, Taddei K, Macaulay SL, Ames D, Fowler C, Maruff P, Masters CL, Rowe CC, Martins RN, AIBL Research Group. The relationship between sleep quality and brain amyloid burden. SLEEP 2016;39(5):1063–1068. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area
Conclusions:A normal number of galanin-immunoreactive VLPO neurons in narcolepsy type 1 brains at autopsy suggests that VLPO cell loss is an unlikely explanation for the sleep fragmentation that often accompanies the disease.Citation:Gavrilov YV, Ellison BA, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE, Valko PO. Disrupted sleep in narcolepsy: exploring the integrity of galanin neurons in the ventrolateral preoptic area. SLEEP 2016;39(5):1059–1062. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Risk of Narcolepsy after AS03 Adjuvanted Pandemic A/H1N1 2009 Influenza Vaccine in Adults: A Case-Coverage Study in England
Conclusions:
We found a significantly increased risk of narcolepsy in adults following Pandemrix vaccination in England. The risk was lower than that seen in children using a similar study design.
Citation:
Stowe J, Andrews N, Kosky C, Dennis G, Eriksson S, Hall A, Leschziner G, Reading P, Shneerson JM, Donegan K, Miller E. Risk of narcolepsy after AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine in adults: a case-coverage study in England. SLEEP 2016;39(5):1051–1057. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Hypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1
Conclusions:Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep.Citation:Alakuijala A, Sarkanen T, Partinen M. Hypocretin-1 levels associate with fragmented sleep in patients with narcolepsy type 1. SLEEP 2016;39(5):1047–1050. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Objective but Not Subjective Short Sleep Duration Associated with Increased Risk for Hypertension in Individuals with Insomnia
Conclusions:
Objectively measured short sleep duration increased the odds of reporting hypertension more than threefold after adjusting for potential confounders; this relationship was not significant for subjectively measured sleep duration. This research supports emerging evidence that insomnia with objective short sleep duration is associated with an increased risk of comorbid hypertension.
Citation:
Bathgate CJ, Edinger JD, Wyatt JK, Krystal AD. Objective but not subjective short sleep duration associated with increased risk for hypertension in individuals with insomnia. SLEEP 2016;39(5):1037–1045. (Source: Sleep)
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Insomnia is Associated with Cortical Hyperarousal as Early as Adolescence
Conclusions:Adolescent insomnia is associated with increased beta EEG power during sleep, which suggests that cortical hyperarousal is present in individuals with insomnia as early as adolescence. Interestingly, cortical hyperarousal is greatest in individuals with insomnia with short sleep duration and may explain the sleep complaints of those with normal sleep duration. Disturbed cortical networks may be a shared mechanism putting individuals with insomnia at risk of psychiatric disorders.Citation:Fernandez-Mendoza J, Li Y, Vgontzas AN, Fang J, Gaines J, Calhoun SL, Liao D, Bixler EO. Insomnia is associated with cortical...
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia
Conclusions:
The widespread high power in a broad beta band reported previously during sleep in insomnia is present as well during eyes closed wakefulness, suggestive of a round-the-clock hyperarousal. Low power in the upper alpha band during eyes open is consistent with low cortical inhibition and attentional filtering. The fine-grained HD-EEG findings suggest that, while more feasible than PSG, wake EEG of short duration with a few well-chosen electrodes and frequency bands, can provide valuable features of insomnia.
Citation:
Colombo MA, Ramautar JR, Wei Y, Gomez-Herrero G, Stoffers D, Wassing R, Benjamins JS, Tagliaz...
Source: Sleep - April 29, 2016 Category: Sleep Medicine Source Type: research
