Characterization of the subsets of human NKT-like cells and the expression of Th1/Th2 cytokines in patients with unexplained recurrent spontaneous abortion
Recurrent spontaneous abortion (RSA) is defined as three or more consecutive spontaneous miscarriages before the 20 week of pregnancy (Ford and Schust, 2009) and is a common condition in obstetrics and gynecology, affecting 2–5% of couples attempting to reproduce (Branch et al., 2010). RSA seriously influences patients’ physical and mental health. RSA has been recognized as a worldwide problem with numerous causes, including parental chromosomal abnormalities, uterine abnormalities, hereditary thrombophilia, endocrine disorders, immunological factors, and/or infections (Kiwi, 2006). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 26, 2015 Category: Allergy & Immunology Authors: Jing Yuan, Jian Li, Shi-Yun Huang, Xin Sun Source Type: research
Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: a possible involvement of local immune reactions
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in the world, with an incidence estimated to be up to 10% (Oyelese et al., 2007; Mousa et al., 2014; Cunningham et al., 2010). Various conditions such as abnormal placentation, trauma to the genital tract, uterine atony, and coagulation defects are known causes of PPH (Cunningham et al., 2010). Among the above, uterine atony is a major cause of PPH, estimated to be responsible for 70% (Karoshi and Keith, 2009; Oyelese and Ananth, 2010); however, the etiology remains to be clarified in cases of PPH secondary to uterine atony. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 20, 2015 Category: Allergy & Immunology Authors: Mustari Farhana, Naoaki Tamura, Mari Mukai, Kotomi Ikuma, Yukiko Koumura, Naomi Furuta, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Kazuhiro Sugihara, Hiroaki Itoh, Naohiro Kanayama Source Type: research
Histological characteristics of the myometrium in the postpartum hemorrhage of unknown etiology: possible involvement of local immune reactions
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in the world, with an incidence estimated to be up to 10% (Oyelese et al., 2007, Mousa et al., 2014, Cunningham et al., 2010). Various conditions such as abnormal placentation, trauma to the genital tract, uterine atony, and coagulation defects are known causes of PPH (Cunningham et al., 2010). Among the above, uterine atony is a major cause of PPH, estimated to be responsible for 70% (Karoshi and Keith, 2009, Oyelese and Ananth, 2010); however, the etiology remains to be clarified in cases of PPH secondary to uterine atony. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 20, 2015 Category: Allergy & Immunology Authors: Mustari Farhana, Naoaki Tamura, Mari Mukai, Kotomi Ikuma, Yukiko Koumura, Naomi Furuta, Chizuko Yaguchi, Toshiyuki Uchida, Kazunao Suzuki, Kazuhiro Sugihara, Hiroaki Itoh, Naohiro Kanayama Source Type: research
Soluble hla-g in pregnancies complicated by autoimmune rheumatic diseases
Autoimmune rheumatic diseases in pregnancy are associated with increased rates of pre-eclampsia, impaired fetal growth, prematurity, neonatal autoimmune diseases, congenital heart block, and stillbirth (Andreoli et al., 2010, Brucato et al., 2011, Ostensen et al., 2011, Canti et al., 2012). Early in the first trimester of pregnancy it is possible to identify subjects with markers of rheumatic diseases who are at risk for subsequent pregnancy complications (Spinillo et al., 2008a, 2008b, 2012). The interaction between pregnancy and rheumatic diseases is complex. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 20, 2015 Category: Allergy & Immunology Authors: Fausta Beneventi, Carla Badulli, Elena Locatelli, Roberto Caporali, Véronique Ramoni, Chiara Cavagnoli, Margherita Simonetta, Giulia Garbin, Carmine Tinelli, Claudia Alpini, CarloMaurizio Montecucco, Miryam Martinetti, Arsenio Spinillo Source Type: research
Decidual natural killer cells regulate vessel stability: implications for impaired spiral artery remodelling
The human uterus undergoes extensive vascular remodelling. Before implantation, angiogenic events occur in the endometrium, as part of the decidualisation process. Following implantation, specialised fetally derived cells of the placenta, the extravillous trophoblast (EVT), invade the decidua and remodel the maternal uterine arteries by removing and replacing the vascular cells that line the arteries (Pijnenborg et al., 2006). During early pregnancy, the uterine spiral arteries are remodelled into larger diameter, higher flow vessels, allowing a 10-fold increase in blood supply into the intervillous space for placental upt...
Source: Journal of Reproductive Immunology - May 12, 2015 Category: Allergy & Immunology Authors: Rupsha Fraser, Guy St.J. Whitley, Baskaran Thilaganathan, Judith E. Cartwright Source Type: research
The effect of thyroid autoimmunity on t-cell responses in early pregnancy
Thyroid autoimmunity (TAI) is the most common autoimmune disorder, affecting 5–20% of the female population during their reproductive period (McLeod and Cooper, 2012). It is the main cause of overt or subclinical hypothyroidism in women of childbearing age (Poppe et al., 2008). There is considerable evidence for the association between TAI, with or without thyroid dysfunction, and menstrual irregularities, fertility problems, and increased morbidity in pregnancy (Kennedy et al., 2010, Lazzarin et al., 2012, Bagis et al., 2001). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 8, 2015 Category: Allergy & Immunology Authors: Ozlem Turhan Iyidir, Ceyla Konca Degertekin, Cemile Sonmez, Ayşegül Atak Yucel, Mehmet Erdem, Mujde Akturk, Goksun Ayvaz Source Type: research
Association study of forkhead box P3 gene polymorphisms with unexplained recurrent spontaneous abortion
Recurrent spontaneous abortion (RSA), classically defined as three or more miscarriages before the 20th week of gestation, affects 1–2% of couples (Macklon et al., 2002; Li et al., 2002; Pandey et al., 2005). After several decades of research, a variety of causes have been confirmed to be involved in the pathogenesis of RSA, including anatomical (10%), infectious (1–2%), hormonal (15%), thrombophilic (20%), immunological (15%), and genetic (2–5%) factors. However, in other cases the cause of RSA remains unexplained (unexplained recurrent spontaneous abortion [URSA]) (Laird et al., 2003; Ford and Schust, 2009). (Sourc...
Source: Journal of Reproductive Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Faezeh Naderi-Mahabadi, Saeed Zarei, Ramina Fatemi, Koorosh Kamali, Zhamak Pahlavanzadeh, Mahmood Jeddi-Tehrani, Tohid Kazemi, Farah Idali Source Type: research
Association study of Gene Polymorphisms with Unexplained Recurrent Spontaneous Abortion
Recurrent spontaneous abortion (RSA), classically defined as three or more miscarriages before the 20th week of gestation, affects 1–2% of couples (Macklon et al., 2002, Li et al., 2002, Pandey et al., 2005). After several decades of research, a variety of causes have been confirmed to be involved in the pathogenesis of RSA, including anatomical (10%), infectious (1–2%), hormonal (15%), thrombophilic (20%), immunological (15%), and genetic (2–5%) factors. However, in other cases the cause of RSA remains unexplained (unexplained recurrent spontaneous abortion [URSA]) (Laird et al., 2003, Ford and Schust, 2009). (Sourc...
Source: Journal of Reproductive Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Faezeh Naderi-Mahabadi, Ramina Fatemi, Saeed Zarei, Koorosh Kamali, Zhamak Pahlavanzadeh, Tohid Kazemi, Mahmood Jeddi-Tehrani, Farah Idalia Source Type: research
The effect of secondary cholestasis on the CD68-positive and CD163-positive macrophage population, cellular proliferation, and apoptosis in rat testis
Hypogonadism is an significant complication of chronic liver disease (Galvão-Teles et al., 1973; Kaymakoğlu et al., 1995; Nitsche et al., 2014). For many decades, the pathogenesis of the testicular atrophy and feminization that occurs in men with chronic liver disease has fascinated both clinicians and biochemists (Galvão-Teles et al., 1973). The degree of hypogonadism and feminization correlates well with the severity of cirrhosis (Kaymakoğlu et al., 1995). Up to now, the pathogenesis of hypogonadism in male patients with chronic liver disease is complex and not well explained (Galvão-Teles et al., 1973; Kaymakoğlu ...
Source: Journal of Reproductive Immunology - April 25, 2015 Category: Allergy & Immunology Authors: Shao-Hua Shi, Li Jiang, Hai-Yang Xie, Jian Xu, You-Fa Zhu, Shu-Sen Zheng Source Type: research
Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive
Internationally, hormonal contraceptives (HCs) are widely used by women to prevent unplanned pregnancies. In South Africa, more than half of women aged 15–49 years old use depot medroxyprogesterone acetate (DMPA) or norethisterone enanthate (Net-EN), with more than three times the number of women using DMPA than Net-EN (Sibeko et al., 2011, Department of Health, 2007). DMPA is an aqueous microcrystalline suspension (150mg/ml) administered by intramuscular depot injection every three months, while NET-EN injection contains 200mg/ml of norethisterone, which is effective for two months as contraception (Fraser and Weisberg,...
Source: Journal of Reproductive Immunology - April 22, 2015 Category: Allergy & Immunology Authors: Sinaye Ngcapu, Lindi Masson, Sengeziwe Sibeko, Lise Werner, Lyle R. McKinnon, Koleka Mlisana, Muki Shey, Natasha Samsunder, Salim Abdool Karim, Quarraisha Abdool Karim, Jo-Ann S. Passmore Source Type: research
First-Trimester Maternal Cell Microrna is a Superior Pregnancy Marker To Immunological Testing For Predicting Adverse Pregnancy Outcome
An immunological basis for “unexplained” implantation failure, miscarriage and late term pregnancy complications/failures has been supported in numerous studies (Beer et al., 1996, Beer and Kwak, 1997; Coulam et al., 1995; Kwak et al., 1998a, 1998b, 2000; Kwak-Kim et al., 2003; Ng et al., 2002; Saito et al., 2007; Steinborn et al., 2008; Thum, 2007; Winger et al., 2012). Such cases have often been associated with abnormalities in several different in vitro immune parameters: natural killer cell cytotoxicity, proportion of peripheral blood CD56+CD3- cells, and Th1:Th2 bias. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - April 15, 2015 Category: Allergy & Immunology Authors: Edward E. Winger, Jane L. Reed, Xuhuai Ji Source Type: research
Expression and localization of interleukin 1 beta and interleukin 1 receptor (type I) in the bovine endometrium and embryo
Cytokines, initially identified as peptides and protein secretory products of immune cells, play important roles in the endometrial physiology and maternal regulation of embryonic development (Robertson et al., 1992; Singh et al., 2011). In mammals, deregulated expression of cytokines can lead to total or partial failure of implantation and abnormal placental formation (Guzeloglu-Kayisli et al., 2009). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - April 15, 2015 Category: Allergy & Immunology Authors: Eva Correia-Álvarez, Enrique Gómez, David Martín, Susana Carrocera, Silvia Pérez, Jesús Otero, Nathalie Peynot, Corinne Giraud-Delville, José Néstor Caamaño, Olivier Sandra, Véronique Duranthon, Marta Muñoz Source Type: research
Effect of immunization against prostate- and testis-expressed (PATE) proteins on sperm function and fecundity in the rat
The immature and non-motile spermatozoa produced in the testis undergo maturation when they pass through the epididymis. Sperm maturation is facilitated by a number of proteins secreted by the epididymal epithelial cells into the luminal fluid, which then bind on to the sperm surface (Ducheux et al., 2003). Defensins (Yenugu et al., 2004, 2006, Travis et al., 2000), members of the sperm-associated antigen 11 family (Hamil et al., 2000), lysozymes (Zhang et al., 2005, Mandal et al., 2003), lipocalins (Hamil et al., 2003), cathelicidins, protease inhibitors (Hamil et al., 2002, Blankenvoorde et al., 1998, Hiemstra et al., 19...
Source: Journal of Reproductive Immunology - April 9, 2015 Category: Allergy & Immunology Authors: Angireddy Rajesh, Suresh Yenugu Source Type: research
Blood SC5b-9 complement levels increase at parturition during term and preterm labor
Parturition is a physiological process that requires the synchronization of uterine contractions, cervical dilatation, and membrane rupture. Several reviews have emphasized that the physiological phenomena, molecules, and cellular mechanisms that drive the process of human parturition are not completely understood (Breuiller-Fouche and Germain, 2006). The complement system is an important effector of the immune system because it forms pores in cell membranes that lead to cell lysis; thus, the complement system is thought to play a crucial role during parturition. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - April 2, 2015 Category: Allergy & Immunology Authors: Enrique Segura-Cervantes, Javier Mancilla-Ramirez, Luis Zurita, Yuriria Paredes, José Luis Arredondo, Norma Galindo-Sevilla Source Type: research
Blood SCb-9 complement levels increase at parturition during term and preterm labor
Parturition is a physiological process that requires the synchronization of uterine contractions, cervical dilatation, and membrane rupture. Several reviews have emphasized that the physiological phenomena, molecules, and cellular mechanisms that drive the process of human parturition are not completely understood (Breuiller-Fouche and Germain, 2006). The complement system is an important effector of the immune system because it forms pores in cell membranes that lead to cell lysis; thus, the complement system is thought to play a crucial role during parturition. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - April 2, 2015 Category: Allergy & Immunology Authors: Enrique Segura-Cervantes, Javier Mancilla, Luis Zurita, Yuriria Paredes, José Luis Arredondo, Norma Galindo-Sevilla Source Type: research
