Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture
Endometriosis is a gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. It comprises peritoneal, ovarian, and deep-infiltrating endometriosis leading to pelvic pain, dysmenorrhea, and subfertility (Nnoaham et al., 2011). This estrogen-dependent disease affects 10–15% of women of reproductive age (Hey-Cunningham et al., 2013), and its prevalence is described in up to 50% of women undergoing assisted reproduction (Eskenazi and Warner, 1997). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - September 9, 2014 Category: Allergy & Immunology Authors: Linda Söhngen, Markus Schmidt, Pauline Wimberger, Rainer Kimmig, Ruth Grümmer Source Type: research
Neutrophil extracellular traps formation by bacteria causing endometritis in the mare
In response to inflammatory stimuli, neutrophils (PMNs) migrate from blood circulation and are recruited into sites of inflammation in different tissues. They are the first line of innate immune defense against the invading bacteria (Brinkmann, 2011). The PMNs present in the bloodstream firmly adhere to the endothelium cell barrier, cross it, and reach the tissue at the site of infection. There, chemokines released by mast cells and resident tissue macrophages activate the PMNs (Souza et al., 2011). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - August 26, 2014 Category: Allergy & Immunology Authors: M.R. Rebordão, C. Carneiro, G. Alexandre-Pires, P. Brito, C. Pereira, T. Nunes, A. Galvão, A. Leitão, C. Vilela, G. Ferreira-Dias Source Type: research
Health and disease in children born after assistive reproductive therapies (ART)
In vitro fertilisation (IVF), which emerged only 35 years ago and is still advancing, offers hope to the estimated 10% of couples worldwide considered subfertile (Boivin et al., 2007; Shufaro and Laufer, 2013). There is little doubt as to the important role that assisted reproductive therapies (ART) play in modern society: Robert Edwards, who pioneered IVF, was awarded a Nobel Prize in 2010, and IVF has been suggested to be one of the six most important medical inventions (Table 1). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - August 17, 2014 Category: Allergy & Immunology Authors: Mariyum Hyrapetian, Eva M. Loucaides, Alastair G. Sutcliffe Tags: Mini Review Source Type: research
Health and disease in children born after assistive reproductive therapies (ART)
In-vitro fertilisation (IVF) and other assisted reproductive therapies (ART) offer hope to subfertile couples worldwide. At least 5 million ART children have been born to date. Their health is an issue that is increasingly relevant: first, to those children and young adults themselves; second, to couples considering fertility treatment; and third, to the general population as ART has progressed from experimental treatment to routine practice. Many concerns about the potential risks to these children have been voiced with varying degrees of supportive evidence. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - August 17, 2014 Category: Allergy & Immunology Authors: Mariyum Hyrapetian, Eva M. Loucaides, Alastair G. Sutcliffe Source Type: research
Hormonal regulation of the cytokine microenvironment in the mammary gland
During the ovarian cycle, the mammary gland epithelium undergoes proliferation, differentiation and apoptosis under the direction of ovarian hormones oestrogen and progesterone (Fata et al., 2001; Ramakrishnan et al., 2002), and this cellular turnover has been linked to the high susceptibility of the mammary gland to tumour formation (Ramakrishnan et al., 2002). During the oestrus phase of the cycle, the mammary epithelium exhibits a basic ductal structure. As serum progesterone rises, secondary branching and alveolar bud development occur, with alveolar bud appearance predominantly during dioestrus (Fata et al., 2001). (S...
Source: Journal of Reproductive Immunology - July 30, 2014 Category: Allergy & Immunology Authors: Pallave Dasari, David J. Sharkey, Effarina Noordin, Danielle J. Glynn, Leigh J. Hodson, Peck Y. Chin, Andreas Evdokiou, Sarah A. Robertson, Wendy V. Ingman Source Type: research
