Neonatal alloimmune thrombocytopenia caused by maternal past lymphocytes immunotherapy: a case report
Background: Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on fetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Especially anti-HLA class I antibodies are often produced by pregnancy and blood transfusion. Here we report a rare case of neonatal thrombocytopenia observed in a female infant delivered by woman with history of lymphocytes immunotherapy for habitual abortion. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: M. Ito, S. Soeda, S. Yoneda, Y. Ono, N. Yoneda, A. Shiozaki, S. Saito Source Type: research
Contribution of the NKG2D receptor to murine placental development
Peripheral blood natural killer (NK) cells control viral infections and cancer by their cytotoxic ability. In contrast, uterine NK (uNK) cells, which comprise 70% of leukocytes at the murine fetomaternal interface, have enhanced cytokine-producing ability and play an important role in the maintenance of pregnancy. NKG2D is a major activating receptor of NK cells. Stimulation of uNK cells in vitro by NKG2D ligands expressed on decidual stromal cells and trophoblasts leads to production of various cytokines by uNK cells; however, in vivo contribution of NKG2D ligand–receptor interactions to placental development is poorly ...
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Y. Aoki, N. Otsuka, N. Yamamoto, T. Miyazaki, Y. Miyatake, M. Kasahara Source Type: research
Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss
Objective: We previously found that low FXII activity, but not an associated common genetic polymorphism, 46C/T, was linked to PRL. There is no reported study indicating the influence of the FXII SNP on further pregnancy outcome. Thus, we conducted this cross-sectional and cohort study. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: E. Hashimoto, T. Ebara, C. Yamada-Namikawa, T. Kitaori, N. Suzumori, K. Katano, Y. Ozaki, M. Sugiura-Ogasawara Source Type: research
Role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in patients with recurrent miscarriage
In this study, we investigated a role of MMPs in patients with recurrent miscarriage. With informed consent, decidua and villi were surgically collected from patients with recurrent miscarriage. A chromosome analysis of villi was performed using G-band staining. We investigate the expression of MMP-2 and MMP-9 using immunohistochemistry and ELISA. Non-parametric analysis was applied for statistical comparison of differences. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Y. Obayashi, Y. Ozaki, S. Kurakane, S. Goto, K. Kumagai, T. Kitaori, N. Suzumori, M. Sugiura Source Type: research
The serum level of vitamin D of endometriosis patients
Vitamin D (VD) has been known to control the immune system. Low serum level of VD has been reported in various chronic inflammatory diseases. Although variations of genes associated with VD have been shown in endometriosis (EM), there are only a few and controversial reports regarding serum levels VD in EM. The aim of this study was to measure serum levels of VD in EM. Under informed consents, sera were taken from 37 control women, 17 of stage I-II and 22 of stage III - IV EM patients. All samples were taken in fall or winter to avoid the influence of sun exposure. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: M. Miyashita, K. Koga, M. Nagai, A. Taguchi, F. Sue, T. Makabe, G. Izumi, M. Takamura, M. Harada, T. Hirata, Y. Hirota, Y. Osuga, T. Fujii Source Type: research
Editorial Board
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Source Type: research
Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content
Regulatory T cells (Treg) play an important role in the induction and maintenance of tolerance (Sakaguchi et al., 1995; Sakaguchi, 2005). In 2004, Aluvihare et al. and our group first reported that Treg cells might mediate maternal tolerance to the fetus in mice and humans (Aluvihare et al., 2004; Sasaki et al., 2004). Since then, many lines of evidence supporting the importance of Treg cells in the implantation period and the early pregnancy period have been presented, with more detailed characterization of Treg cells in mice (Zenclussen et al., 2005, 2006; Darrasse-Jeze et al., 2006; Kallikourdis et al., 2007; Robertson ...
Source: Journal of Reproductive Immunology - October 16, 2014 Category: Allergy & Immunology Authors: Kumiko Inada, Tomoko Shima, Mika Ito, Akemi Ushijima, Shigeru Saito Source Type: research
Early pregnancy vitamin D and patterns of antenatal inflammation in African–American women
Vitamin D is essential for the health of both mother and fetus during pregnancy (Shin and Choi, 2010). In addition to an essential role in bone health, growing evidence shows that vitamin D is involved in the inflammatory response (Adams and Hewison, 2008). Although inflammation has been linked to poor birth outcomes (Lyon D et al., 2010), little is known about the relationship between vitamin D and inflammation during pregnancy. In the nonpregnant state, vitamin D is important in the regulation of the immune system and inflammation. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - October 14, 2014 Category: Allergy & Immunology Authors: Kevin R. Bobbitt, Rosalind M. Peters, Jia Li, Sudhaker D. Rao, Kimberley J. Woodcroft, Andrea E. Cassidy-Bushrow Source Type: research
CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection
Foetal tolerance is essential for the survival of the semi-allogeneic foetus during pregnancy. Without this tolerance, the maternal immune system would rapidly mount an attack on this “foreign object”, destroying the developing cells of the foetus in the same manner as it would an invading pathogen. To induce this tolerance, changes must take place in the normal function of maternal immune cells. Different viruses use different mechanisms of host evasion and immune cell alteration to increase their chance of survival, and various pathogens, including respiratory viruses, have developed the ability to take advantage of ...
Source: Journal of Reproductive Immunology - October 9, 2014 Category: Allergy & Immunology Authors: Rebecca L. Vanders, Vanessa E. Murphy, Peter G. Gibson, Philip M. Hansbro, Peter A.B. Wark Tags: Review Source Type: research
CD8T cells and Dendritic Cells: Key Players in the Attenuated Maternal Immune Response to Influenza Infection
Foetal tolerance is essential for the survival of the semi-allogeneic foetus during pregnancy. Without this tolerance, the maternal immune system would rapidly mount an attack on this “foreign object”, destroying the developing cells of the foetus in the same manner as it would an invading pathogen. To induce this tolerance, changes must take place in the normal function of maternal immune cells. Different viruses use different mechanisms of host evasion and immune cell alteration to increase their chance of survival, and various pathogens, including respiratory viruses, have developed the ability to take advantage of ...
Source: Journal of Reproductive Immunology - October 9, 2014 Category: Allergy & Immunology Authors: Rebecca L. Vanders, Vanessa E. Murphy, Peter G. Gibson, Philip M. Hansbro, Peter A.B. Wark Tags: Review Source Type: research
Prevalence of antiphospholipid antibodies and risk of subsequent adverse obstetric outcomes in women with prior pregnancy loss
Early pregnancy loss is a common problem that occurs in approximately 12–14% of clinically recognized pregnancies and up to 30% of conceptions (Branch et al., 2010). Approximately 2% of women attempting pregnancy experience two consecutive pregnancy losses, and 0.4–1% experience three consecutive losses (Branch et al., 2010, Salat-Baroux, 1988). While most remain unexplained, recurrent early miscarriages (REM) are usually pre-embryonic or embryonic ( (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - October 9, 2014 Category: Allergy & Immunology Authors: Zachary S. Bowman, Vera Wünsche, T. Flint Porter, Robert M. Silver, D. Ware Branch Source Type: research
Role of zona pellucida glycoproteins during fertilization in humans
Fertilization involves the fusion of two highly differentiated haploid gametes (the egg and the spermatozoon) leading to the formation of a single cell embryo, which is essential for generating new progeny. During fertilization, spermatozoa initially bind to the zona pellucida (ZP). The ZP is an extracellular, glycoproteinaceous coat that surrounds mammalian oocytes. Under physiological conditions, ZP matrix plays an important role in taxon-specific binding of the spermatozoa to the oocyte and induction of the acrosome reaction in the spermatozoa bound to ZP. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - October 3, 2014 Category: Allergy & Immunology Authors: Satish Kumar Gupta Source Type: research
Finis Ab Orígine Pendet
The ancient latin quote ‘Finis ab Orígine Pendet’, sometimes attributed to Marcus Manilius, instructs us that ‘the ending depends on the beginning’. Obviously, this quote raises the philosophical question how ‘the beginning’ can be defined? With regard to extrauterine life, the beginning is often considered as the day of birth. In this special issue ‘Pre-conceptional and prenatal determinants of fetal development’, we have revisit ‘the beginning’ of life from the perspectives of reproductive biologists, immunologists, and geneticists in basic and clinical sciences. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - October 1, 2014 Category: Allergy & Immunology Authors: Petra Arck, D. Ware Branch, Maria Emilia Solano Tags: Editorial Source Type: research
Editorial Board
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - October 1, 2014 Category: Allergy & Immunology Source Type: research
triggers NLRP3 inflammasome recruitment in THP-1 monocytes
Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age and is characterized by an absence of protective Lactobacillus spp. and overgrowth of anaerobic and facultative bacteria including Gardnerella vaginalis (Holst et al., 1987). Although the bacterium is observed in asymptomatic women, it occurs in up to 96% of BV cases (Borchardt et al., 1989). G. vaginalis has also consistently been observed in conjunction with gynecological and obstetric disease states including pelvic inflammatory disease, endometritis, intra-amniotic infection, miscarriage, premature labor, preterm delivery, fetal brain in...
Source: Journal of Reproductive Immunology - September 14, 2014 Category: Allergy & Immunology Authors: Eric J. Vick, Hyo S. Park, Krista A. Huff, Kenneth M. Brooks, Anthony L. Farone, Mary B. Farone Source Type: research
