Neonatal alloimmune thrombocytopenia caused by maternal past lymphocytes immunotherapy: a case report

Background: Neonatal alloimmune thrombocytopenia (NAIT) occurs as a result of maternal alloimmunization against paternally inherited antigens on fetal platelets. Platelets express platelet specific antigens (HPA) along with human leucocyte antigens (HLA) class I. Especially anti-HLA class I antibodies are often produced by pregnancy and blood transfusion. Here we report a rare case of neonatal thrombocytopenia observed in a female infant delivered by woman with history of lymphocytes immunotherapy for habitual abortion.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research