Pathophysiological role of cellular senescence in the mouse postpartum endometrium
It has been reported that cellular senescence, defined as an irreversible cell cycle arrest, affects the microenvironment in cancers and other diseases. Our previous study demonstrated the presence of decidual cellular senescence in preterm delivery, suggesting its involvement in the endometrial dysfunction. We also found that the normal mouse decidua contains abundant senescent cells, and therefore, we hypothesized that there is a mechanism for the removal of senescent cells under the normal endometrial condition after parturition, and the disruption of this system is associated with the endometrial pathology. (Source: Jo...
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: M. Egashira, Y. Hirota, T. Saito-Fujita, H. Haraguchi, L. Matsumoto, M. Matsuo, T. Hiraoka, Y. Osuga, T. Fujii Source Type: research
Lysophosphatidic acid induces the expression of angiogenic factors in human trophoblast cells – a way of understanding the etiology of PIH
We reported that placental ATX mRNA amount of the women with pregnancy induced hypertension (PIH) were significantly lower than that of normal women. Impaired implantation was reported in mice deficient in LPAR3, one of LPA receptors, suggesting the critical role of this pathway in reproduction. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: M. Ichikawa, T. Nagamatsu, T. Fujii, M. Hoya, Y. Kawai-Iwasawa, K. Oda, K. Kawana, T. Yamashita, Y. Osuga, T. Fujii Source Type: research
Impact of psychological stresses on miscarriage rate in CBA/J×DBA/2J mouse model
Introduction: Psychological stress by repeated miscarriages causes anxiety disorder and depression. Such psychological stresses can be a hidden factor to induce additional miscarriage in women with recurrent pregnancy loss (RPL). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: T. Nagasaka, T. Nagamatsu, E. Inoue, M. Hoya, Y. Iwasawa-Kawai, T. Yamashita, Y. Osuga, T. Fujii Source Type: research
Expression of LPA receptors is elevated in preeclamptic placenta
Lysophosphatidic acid (LPA) is a new class lipid mediator and getting attention for its diverse functions such as cell proliferation and angiogenesis. LPA signaling is thought to be important to maintain normal pregnancy. Our group previously reported that in human placenta complicated with pregnancy induced hypertension (PIH) the production of autotoxin (ATX), a key enzyme of LPA production, was diminished compared with normal placenta. This time we investigated the expressions of LPA receptors in preeclamptic placenta to understand the effect of LPA signaling in the pathogenesis of PIH. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: T. Fujii, T. Nagamatsu, M. Ichikawa, Y. Kawai-Iwasawa, K. Kawana, T. Yamashita, Y. Osuga, T. Fujii Source Type: research
Nanosilica-induced placental inflammation and pregnancy complications: different roles of the inflammasome components NLRP3 and ASC
Nanosilica (NS) particles are frequently used as additives in cosmetics and foods because of their hydrophilic nature and easy functionalization. However, recent investigations caution that increasing use of nanoparticles associated with potentially harmful risks to human health, little is known about their effects on placental inflammation and pregnancy complications. Inflammasomes as sterile inflammation, are large multiprotein complexes in the cytosol that regulate the production of the pivotal inflammatory cytokine interleukin (IL)-1beta. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: K. Shirasuna, F. Usui, T. Karasawa, H. Kimura, A. Kawashima, H. Mizukami, A. Ohkuchi, M. Takahashi Source Type: research
Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition
554 women were recruited for the outpatient clinic of the Department of Obstetrics and Gynecology, Tokushima University Hospital. We divided the women into seven stages by menstrual regularity and FSH level: mid-reproductive stage, late reproductive stage, early menopausal transition, late menopausal transition, very early postmenopause, early postmenopause and late postmenopause. We measured serum concentrations of nine cytokines (IL-1β, IL-5, IL-6, IL-7, IL-8, IL-10, TNF-α, MIP-1β and MCP-1). IL-8 levels in postmenopausal women were significantly (p=0.001) higher than those in women in the mid- or reproductive stage a...
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: A. Tani, T. Yasui, K. Kasai, K. Keyama, S. Matsui, T. Kato, M. Irahara Source Type: research
Establishment of new ELISA system for HLA-G
HLA-G is considered as key molecules to protect fetus from maternal immune cells, since HLA-G is strongly expressed on placental trophoblast and has low polymorphism. HLA-G has 2 isoforms, membrane-bound form and soluble form. Especially, soluble HLA-G (sHLA-G) has been examined widely by ELISA system, and many reports have demonstrate that sHLA-G levels in plasma are lower in patients from recurrent abortion or from pregnancy-induced hypertension than in those who experienced normal pregnancy. On the other hand, the presence of HLA-G in the body fluid has been questioned, because the concentration of HLA-G in plasma was d...
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: N. Ouji-Sageshima, M. Akasaki, D.E. Geraghty, E. Kita, A. Ishitani, K. Hatake, T. Ito Source Type: research
Urokinase-type plasminogen activator (uPA) system and invasion of early human extravillous trophoblast is regulated by hypoxia induced factor (HIF) pathway
In this study, we investigated the connection of hypoxia-induced factor (HIF) and uPA on primary EVTs to define the intracellular and extracellular protease pathway on early pregnancy. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: N. Koike, T. Tsunemi, J. Akasaka, A. Shigemitsu, C. Yoshimoto, K. Naruse, H. Kobayashi Source Type: research
Possible induction of murine miscarriages through activation of DEC-205+ dendritic cells by glycolipid antigens
Objective: We have recently reported that the imbalance between two distinct types of dendritic cells (DCs), DEC-205+ DCs and 33D1+ DCs, causes the murine abortion (Immunobiol., 217:951, 2012). It has been reported that the activation of type I invariant NKT (iNKT) cells could also induce murine abortion. We have detected the accumulation of DEC-205+ DCs as well as iNKT cells at the sites of murine miscarriages induced by the injection of glycolipid antigen, α-galactosylceramide (α-GalCer), a ligand for CD1d-restricted iNKT cells. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Y. Negishi, T. Ichikawa, T. Takeshita, H. Takahashi Source Type: research
Progesterone transcriptionally inhibits LPS-induced matrix metalloproteinase up-regulation in human cervical fibroblast cells
This study was undertaken to evaluate the effect of progesterone (P4) on the gene expression profile of extracellular matrix (ECM)-associated molecules in human uterine cervical fibroblasts (UCFs) treated with lipopolysaccharides (LPS). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Y. Kuwabara, A. Katayama, S. Kurihara, M. Yonezawa, N. Ouchi, R. Sawa, T. Takeshita Source Type: research
Analysis of miRNA–mRNA expression profiles in decidual natural killer cells during early pregnancy
Objective: Decidual natural killer (dNK) cells play an important role in the maintenance of early pregnancy. However, the expression profiles and functions of miRNAs within dNK cells remain to be clarified. We investigated the miRNA–mRNA expression profiles in dNK cells during early pregnancy. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: D. Zhao, B. Than Naing, K. Inada, T. Shima, S. Saito, T. Takeshita, T. Takizawa Source Type: research
Frequent infection in vertically HIV-infected children in Vietnam
Objective: Chlamydophila pneumoniae (C. pneumoniae) is an intracellular pathogen and often cause fatal respiratory symptoms in HIV/AIDS patients. However, its frequency in children with vertical HIV infection is so far unknown. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: Q.D. Trinh, N.T. Pham, N.T. Le Nguyen, B.Q. Lam, K.T. Le Phan, K.H. Truong, T.Q. Le, H.T. Nguyen, T.C. Tang, Y. Izumi, S. Komine-Aizawa, H. Ushijima, S. Hayakawa Source Type: research
inhibits trophoblast invasion
In this study, we investigated in vitro effects of a periodontal bacteria Porphyromonas gingivalis on cultured trophoblasts and mucosal natural killer cells to mimic in vivo phenomena at the feto-maternal interface. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: N. Hirohata, S. Komine-Aizawa, S. Hayakawa Source Type: research
Maternal and fetal effects of pandemic H1N1 2009 influenza virus infection on pregnant mice
Pandemic A (H1N1) 2009 influenza virus infection may become severe in pregnant women. The mechanisms that the infection becomes severe during pregnancy are not understood well. To address this phenomenon, pregnant and nonpregnant C57BL/6 mice were infected with K4 (A/Kyoto/2011(H1N1)) and the maternal and fetal effects of the infection on pregnant mice were examined. We used the 12–17 week-old nonpregnant and pregnant mice. The mice were intranasally inoulated with 50μl of 5×104PFU/body. After inoculation, we measured the mice body weight and survival rate. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: A. Kasuga, H. Takahashi, T. Murase, M. Yamazaki, T. Yamamoto Source Type: research
The ratio of expression of angiotensin receptors type 1 (AT1), type 2 (AT2) mRNA in local endometriosis lesions and eutopic endometrium
Objective: The rennin–angiotensin system (RAS) is activation cascade that plays a key role in the regulation of blood pressure and the hydro-electrolytic balance. Angiotensin II acts mainly through AT1 receptors and AT2 receptors have opposite functions. Angiotensin II in endometrial stromal cells was mediated via AT1 receptor. We already reported the expression of AT1, AT2 receptors mRNA in local endometriosis lesions at 28th JSIR congress. We investigated into the ratio of expression of AT1, AT2 receptors in local lesions of endometriosis and eutopic endometrium. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - November 1, 2014 Category: Allergy & Immunology Authors: T. Nakao, F. Chishima, C. Hayashi, M. Suzuki, G. Ichikawa, K. Sugita, T. Yamamoto Source Type: research
