COX-2 gene promoter DNA methylation status in eutopic and ectopic endometrium of Egyptian women with endometriosis
Background: The pathophysiology of COX-2 expression in endometriosis is a matter of debate.Aim: To investigate the role of DNA methylation of NF-IL6 site within the promoter of COX-2 gene in the pathogenesis of endometriosis.Methods: The endometrial tissues (ectopic and eutopic) were collected from 60 women with endometriosis and 30 women without endometriosis (control group). The methylation status of COX-2 was examined by methylation specific PCR. Quantitative real-time PCR (RT-PCR) was performed to measure COX-2 mRNA level in endometrial tissues. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 18, 2015 Category: Allergy & Immunology Authors: Haidy E Zidan, Noha A Rezk, Amr Abd Almohsen Alnemr, Amany M. Abd el Ghany Source Type: research
Male fertility and Apoptosis in Normal Spermatogenesis are Regulated by Vacuolar-ATPase Isoform a2
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 18, 2015 Category: Allergy & Immunology Authors: Mukesh K. Jaiswal, Varkha Agrawal, Gajendra K. Katara, Sahithi Pamarthy, Arpita Kulshrestha, Gerard Chaouat, Alice Gilman-Sachs, Kenneth D. Beaman Source Type: research
Placental hypoxia, endoplasmic reticulum stress and maternal endothelial sensitisation by sFLT1 in pre-eclampsia.
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 18, 2015 Category: Allergy & Immunology Authors: D.Stephen Charnock-Jones Source Type: research
Plasma YKL-40 during pregnancy and gestational diabetes mellitus
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 14, 2015 Category: Allergy & Immunology Authors: Anders R. Rinnov, Camilla N. Rathcke, Lisbeth Bonde, Tina Vilsbøll, Filip K. Knop Source Type: research
Galectin-1 reduced the effect of LPS on the IL-6 production in decidual cells by inhibiting LPS on the stimulation of IκBζ
(Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 14, 2015 Category: Allergy & Immunology Authors: Fernando Gómez-Chávez, Violeta Castro-Leyva, Aurora Espejel-Núñez, Rubén G. Zamora-Mendoza, Haydee Rosas-Vargas, Juan C. Cancino-Díaz, Mario E. Cancino-Díaz, Guadalupe Estrada-Gutierrez, Sandra Rodríguez-Martínez Source Type: research
An essay of reflection: Why does preeclampsia exist in humans, and why are there such huge geographical epidemiological differences?
This paper will try to recall the four main objectives of the workshop 2014 in Reunion island: A) Reflection on Preeclampsia (PE) in the light of Evolution: why preeclampsia has emerged in humans (and not in other mammals)? B) Epidemiology: emerging at the end of the 1990's and reaching a large consensus around 2005-2006, there are two different kinds of PE roughly on both sides of the 34th week of gestation: early onset and late onset PE. Our reflections will show that there are indeed major geographical differences concerning early onset PE and late onset PE in the world. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 10, 2015 Category: Allergy & Immunology Authors: Pierre-Yves Robillard, Gustaaf Dekker, Silvia Iacobelli, Gérard Chaouat Source Type: research
Immunoglobulin G concentration in canine colostrum: Evaluation and variability
The immune status of the newborn puppy depends entirely on colostrum ingestion, since canine neonates are nearly agammaglobulinemic at birth (Bouchard et al., 1992). From all circulating immunoglobulins after closure of the intestinal barrier, 90-95% originate from the colostrum (Chastant-Maillard et al., 2012). Inadequate colostrum intake leads to a deficit in the transfer of passive immunity, associated with higher mortality and morbidity rates in calves, lambs and piglets (Christley et al., 2003; Devillers et al., 2011; Virtala et al., 1999), but also in puppies (Mila et al., 2014). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 4, 2015 Category: Allergy & Immunology Authors: Hanna Mila, Alexandre Feugier, Aurélien Grellet, Jennifer Anne, Milène Gonnier, Maelys Martin, Lisa Rossig, Sylvie Chastant-Maillard Source Type: research
MRI-based methods to detect placental and fetal brain abnormalities in utero
Placental insufficiency is characterized by inadequate blood flow to the placenta causing the fetus to receive inadequate amounts of nutrients and oxygen, affecting fetal development while in utero. An early onset of placental insufficiency places fetuses at 40% higher risk of developing brain damage, lung dysfunction and gastrointestinal problems (Keswani et al., 2002). Unfortunately, placental insufficiency doesn’t have any outwards symptoms. Early diagnosis and treatment is vital for the health of both mother and baby. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - July 2, 2015 Category: Allergy & Immunology Authors: Guillermina Girardi Source Type: research
The Effect of Body Mass Index on Post-Vaccination Maternal and Neonatal Pertussis Antibody Levels
The bacterium, Bordatella pertussis, is responsible for pertussis, a highly contagious respiratory infection which most commonly affects young children. Pertussis is particularly dangerous to infants under one year of age who may present with periods of potentially fatal apnea (Cortese et al, 2008). The Centers for Disease Control (CDC) reported 48,277 cases of pertussis in 2012 in the United States, the highest reported number of cases since 1955 (CDC, 2012). Infants cannot be vaccinated against pertussis until approximately two months of age and are thus susceptible to pertussis during this time period. (Source: Journal ...
Source: Journal of Reproductive Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Manisha Gandhi, Sridevi Devaraj, Haleh Sangi-Haghpeykar, Joan Mastrobattista Source Type: research
Selective advantage of HLA matching in successful uncomplicated oocyte donation pregnancies
Oocyte donation (OD) was first introduced in 1984 (Lutjen et al., 1984) and enables women with various causes of reproductive failure to conceive. In their latest annual report on assisted reproductive therapies, the European Society of Human Reproduction and Embryology (ESHRE) published data on 20 countries performing oocyte donation (Kupka et al., 2014). A total of 15,825 fresh transfers after OD were performed, resulting in 6568 pregnancies, and giving a pregnancy rate of 47.4%. This pregnancy rate number is not associated with indication for the oocyte donation (Paulson et al., 1997). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - June 23, 2015 Category: Allergy & Immunology Authors: Lisa E.E.L.O. Lashley, Geert W. Haasnoot, Marijke Spruyt-Gerritse, Frans H.J. Claas Source Type: research
Increased circulating interleukin-17 levels in preeclampsia
Preeclampsia, characterized by hypertension and proteinuria developing after the 20th week of gestation in a previously normotensive woman, is a severe complication of human pregnancy, with a worldwide incidence of 4.6 (2.7–8.2) % (Abalos et al., 2013). It is one of the leading causes of maternal and perinatal morbidity and mortality, even in developed countries. Despite extensive research, the etiology and pathogenesis of preeclampsia are not completely understood. There is an increasing body of evidence that shows that an exaggerated maternal systemic inflammatory response to pregnancy with activation of both the innat...
Source: Journal of Reproductive Immunology - June 23, 2015 Category: Allergy & Immunology Authors: Attila Molvarec, Ibolya Czegle, János Szijártó, János Rigó Source Type: research
Predictive Biomarkers of Preterm Delivery in Women with Ongoing IVF Pregnancies
Currently, 1.5% of infants in the United States are born following in vitro fertilization (IVF) and embryo transfer (Martin et al., 2012). This percentage is expected to increase substantially in the future, mainly as a result of increased age at the time of first attempted conception. Although IVF has succeeded in alleviating many factors contributing to a couple's infertility, IVF pregnancies are more predisposed to adverse outcomes than are spontaneous conceptions. This increased risk is partially due to the elevated rate of multiple pregnancies. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - June 16, 2015 Category: Allergy & Immunology Authors: Tomi T. Kanninen, Giovanni Sisti, Ilana Ramer, Dan Goldschlag, Steven S. Witkin, Steven D. Spandorfer Source Type: research
The CD200 Tolerance-Signaling Molecule and its Receptor, CD200R1, are Expressed in Human Placental Villus Trophoblast and in Peri-implant Decidua BY 5 Weeks’ Gestation
The IgG superfamily glycoprotein CD200 suppresses macrophage/microglial activation, promotes IDO production by macrophages and dendritic cells, suppresses NK and mast cells, induces γδT suppressor cells, and promotes Treg cells by altering dendritic cell maturation (reviewed in Clark and Gorczynski, 2013). CD200-/− mice develop severe autoimmunity and inflammation (Nathan and Muller, 2001). In the CBAxDBA/2 mouse model of spontaneous abortions triggered by TNF-α+IFN-γ, pregnancy loss is prevented by the expression of CD200 in trophoblast and decidua (Clark et al., 2001). (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - June 16, 2015 Category: Allergy & Immunology Authors: David A. Clark, Jorge L. Arredondo, Sukhbinder Dhesy-Thind Tags: Short communication Source Type: research
The role of placental MHC class I expression in immune-assisted separation of the fetal membranes in cattle
The bovine fetus inherits and expresses paternal antigens and is thus semi-allogeneic to the maternal immune system. Preventing immunological rejection of the fetus is, therefore, critical for a successful pregnancy. Maternal antibodies against paternal alloantigens are induced in up to 64% of multiparous cattle and can be detected as early as the second trimester of gestation (Hines and Newman, 1981), showing that the materno-fetal immune response is regulated, rather than suppressed, and is normally not harmful to the fetus. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - June 9, 2015 Category: Allergy & Immunology Authors: Lindert Benedictus, Ad P. Koets, Victor P.M.G. Rutten Source Type: research
Changes in inflammatory mediators in gingival crevicular fluid following periodontal disease treatment in pregnancy: relationship to adverse pregnancy outcome
Periodontitis is an infectious disease process that, in its progressive stage, is a substantial contributor to global oral health disease. Approximately 10 to 15% of the adult population worldwide are affected by periodontal disease, with higher rates observed in indigenous populations (Petersen and Ogawa, 2005, Jamieson et al., 2010). Periodontal disease is characterised by destruction of the periodontal ligament, bone and soft tissue as a result of a local host immune response to microbial plaque on the tooth surface. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - May 27, 2015 Category: Allergy & Immunology Authors: Blagica Penova-Veselinovic, Jeffrey A. Keelan, Carol A. Wang, John P. Newnham, Craig E. Pennell Source Type: research
