The CD200 Tolerance-Signaling Molecule and its Receptor, CD200R1, are Expressed in Human Placental Villus Trophoblast and in Peri-implant Decidua BY 5 Weeks’ Gestation

The IgG superfamily glycoprotein CD200 suppresses macrophage/microglial activation, promotes IDO production by macrophages and dendritic cells, suppresses NK and mast cells, induces γδT suppressor cells, and promotes Treg cells by altering dendritic cell maturation (reviewed in Clark and Gorczynski, 2013). CD200-/− mice develop severe autoimmunity and inflammation (Nathan and Muller, 2001). In the CBAxDBA/2 mouse model of spontaneous abortions triggered by TNF-α+IFN-γ, pregnancy loss is prevented by the expression of CD200 in trophoblast and decidua (Clark et al., 2001).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Tags: Short communication Source Type: research