Expression of LPA receptors is elevated in preeclamptic placenta

Lysophosphatidic acid (LPA) is a new class lipid mediator and getting attention for its diverse functions such as cell proliferation and angiogenesis. LPA signaling is thought to be important to maintain normal pregnancy. Our group previously reported that in human placenta complicated with pregnancy induced hypertension (PIH) the production of autotoxin (ATX), a key enzyme of LPA production, was diminished compared with normal placenta. This time we investigated the expressions of LPA receptors in preeclamptic placenta to understand the effect of LPA signaling in the pathogenesis of PIH.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research