Different circulating levels of monocyte chemoattractant protein-1 and interleukin-8 during the menopausal transition

554 women were recruited for the outpatient clinic of the Department of Obstetrics and Gynecology, Tokushima University Hospital. We divided the women into seven stages by menstrual regularity and FSH level: mid-reproductive stage, late reproductive stage, early menopausal transition, late menopausal transition, very early postmenopause, early postmenopause and late postmenopause. We measured serum concentrations of nine cytokines (IL-1β, IL-5, IL-6, IL-7, IL-8, IL-10, TNF-α, MIP-1β and MCP-1). IL-8 levels in postmenopausal women were significantly (p=0.001) higher than those in women in the mid- or reproductive stage and women in early or late menopausal transition.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research