Pathophysiological role of cellular senescence in the mouse postpartum endometrium

It has been reported that cellular senescence, defined as an irreversible cell cycle arrest, affects the microenvironment in cancers and other diseases. Our previous study demonstrated the presence of decidual cellular senescence in preterm delivery, suggesting its involvement in the endometrial dysfunction. We also found that the normal mouse decidua contains abundant senescent cells, and therefore, we hypothesized that there is a mechanism for the removal of senescent cells under the normal endometrial condition after parturition, and the disruption of this system is associated with the endometrial pathology.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research