Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content

Regulatory T cells (Treg) play an important role in the induction and maintenance of tolerance (Sakaguchi et al., 1995; Sakaguchi, 2005). In 2004, Aluvihare et al. and our group first reported that Treg cells might mediate maternal tolerance to the fetus in mice and humans (Aluvihare et al., 2004; Sasaki et al., 2004). Since then, many lines of evidence supporting the importance of Treg cells in the implantation period and the early pregnancy period have been presented, with more detailed characterization of Treg cells in mice (Zenclussen et al., 2005, 2006; Darrasse-Jeze et al., 2006; Kallikourdis et al., 2007; Robertson et al., 2009; Shima et al., 2010; Kahn and Baltimore, 2010; Guerin et al., 2011; Rowe et al., 2011, 2012; Samstein et al., 2012; Yin et al., 2012) and in humans (Tilburgs et al., 2008, 2009; Sasaki et al., 2007; Yang et al., 2008; Jin et al., 2009; Mei et al., 2010; Wang et al., 2010, 2011; Winger and Reed, 2011; Lee et al., 2011; Steinborn et al., 2012).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research