triggers NLRP3 inflammasome recruitment in THP-1 monocytes

Bacterial vaginosis (BV) is a common vaginal disorder in women of reproductive age and is characterized by an absence of protective Lactobacillus spp. and overgrowth of anaerobic and facultative bacteria including Gardnerella vaginalis (Holst et al., 1987). Although the bacterium is observed in asymptomatic women, it occurs in up to 96% of BV cases (Borchardt et al., 1989). G. vaginalis has also consistently been observed in conjunction with gynecological and obstetric disease states including pelvic inflammatory disease, endometritis, intra-amniotic infection, miscarriage, premature labor, preterm delivery, fetal brain injury, and acquisition of HIV and other sexually transmitted infections (Turovskiy et al., 2011).
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research