Neutrophil extracellular traps formation by bacteria causing endometritis in the mare

In response to inflammatory stimuli, neutrophils (PMNs) migrate from blood circulation and are recruited into sites of inflammation in different tissues. They are the first line of innate immune defense against the invading bacteria (Brinkmann, 2011). The PMNs present in the bloodstream firmly adhere to the endothelium cell barrier, cross it, and reach the tissue at the site of infection. There, chemokines released by mast cells and resident tissue macrophages activate the PMNs (Souza et al., 2011).

Source: Journal of Reproductive Immunology - August 26, 2014 Category: Allergy & Immunology Authors: M.R. Rebordão, C. Carneiro, G. Alexandre-Pires, P. Brito, C. Pereira, T. Nunes, A. Galvão, A. Leitão, C. Vilela, G. Ferreira-Dias Source Type: research