First-Trimester Maternal Cell Microrna is a Superior Pregnancy Marker To Immunological Testing For Predicting Adverse Pregnancy Outcome

An immunological basis for “unexplained” implantation failure, miscarriage and late term pregnancy complications/failures has been supported in numerous studies (Beer et al., 1996, Beer and Kwak, 1997; Coulam et al., 1995; Kwak et al., 1998a, 1998b, 2000; Kwak-Kim et al., 2003; Ng et al., 2002; Saito et al., 2007; Steinborn et al., 2008; Thum, 2007; Winger et al., 2012). Such cases have often been associated with abnormalities in several different in vitro immune parameters: natural killer cell cytotoxicity, proportion of peripheral blood CD56+CD3- cells, and Th1:Th2 bias.
Source: Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research