The effect of secondary cholestasis on the CD68-positive and CD163-positive macrophage population, cellular proliferation, and apoptosis in rat testis

Hypogonadism is an significant complication of chronic liver disease (Galvão-Teles et al., 1973; Kaymakoğlu et al., 1995; Nitsche et al., 2014). For many decades, the pathogenesis of the testicular atrophy and feminization that occurs in men with chronic liver disease has fascinated both clinicians and biochemists (Galvão-Teles et al., 1973). The degree of hypogonadism and feminization correlates well with the severity of cirrhosis (Kaymakoğlu et al., 1995). Up to now, the pathogenesis of hypogonadism in male patients with chronic liver disease is complex and not well explained (Galvão-Teles et al., 1973; Kaymakoğlu et al., 1995; Nitsche et al., 2014).

Source: Journal of Reproductive Immunology - April 25, 2015 Category: Allergy & Immunology Authors: Shao-Hua Shi, Li Jiang, Hai-Yang Xie, Jian Xu, You-Fa Zhu, Shu-Sen Zheng Source Type: research