Association study of Gene Polymorphisms with Unexplained Recurrent Spontaneous Abortion

Recurrent spontaneous abortion (RSA), classically defined as three or more miscarriages before the 20th week of gestation, affects 1–2% of couples (Macklon et al., 2002, Li et al., 2002, Pandey et al., 2005). After several decades of research, a variety of causes have been confirmed to be involved in the pathogenesis of RSA, including anatomical (10%), infectious (1–2%), hormonal (15%), thrombophilic (20%), immunological (15%), and genetic (2–5%) factors. However, in other cases the cause of RSA remains unexplained (unexplained recurrent spontaneous abortion [URSA]) (Laird et al., 2003, Ford and Schust, 2009).

Source: Journal of Reproductive Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Faezeh Naderi-Mahabadi, Ramina Fatemi, Saeed Zarei, Koorosh Kamali, Zhamak Pahlavanzadeh, Tohid Kazemi, Mahmood Jeddi-Tehrani, Farah Idalia Source Type: research