Association study of forkhead box P3 gene polymorphisms with unexplained recurrent spontaneous abortion

Recurrent spontaneous abortion (RSA), classically defined as three or more miscarriages before the 20th week of gestation, affects 1–2% of couples (Macklon et al., 2002; Li et al., 2002; Pandey et al., 2005). After several decades of research, a variety of causes have been confirmed to be involved in the pathogenesis of RSA, including anatomical (10%), infectious (1–2%), hormonal (15%), thrombophilic (20%), immunological (15%), and genetic (2–5%) factors. However, in other cases the cause of RSA remains unexplained (unexplained recurrent spontaneous abortion [URSA]) (Laird et al., 2003; Ford and Schust, 2009).

Source: Journal of Reproductive Immunology - May 7, 2015 Category: Allergy & Immunology Authors: Faezeh Naderi-Mahabadi, Saeed Zarei, Ramina Fatemi, Koorosh Kamali, Zhamak Pahlavanzadeh, Mahmood Jeddi-Tehrani, Tohid Kazemi, Farah Idali Source Type: research