Short term monotherapy with GLP-1 receptor agonist liraglutide or PDE 4 inhibitor roflumilast is superior to metformin in weight loss in obese PCOS women: a pilot randomized study
Conclusion:
Short-term monotherapy with liraglutide or roflumilast was associated with significant weight loss in obese PCOS. Liraglutide was superior to metformin, whereas roflumilast resulted in greater, yet not statistically significant, mean weight loss when compared to metformin. Reduction of body weight with liraglutide resulted in improvement of body composition.Trial registrationClinicalTrials.gov NCT02187250. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 2, 2015 Category: Cancer & Oncology Authors: Mojca JensterleVesna SalamunTomaz KocjanEda Vrtacnik BokalAndrej Janez Source Type: research
An association study between USP34 and polycystic ovary syndrome
Conclusions:
USP34 gene polymorphisms (rs17008097 and rs17008940) may not be associated with PCOS in the Han Chinese women. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 15, 2015 Category: Cancer & Oncology Authors: Shigang ZhaoYe TianWei ZhangXiuye XingTao LiHongbin LiuTao HuangYunna NingHan ZhaoZi-Jiang Chen Source Type: research
Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer
Conclusions:
These results suggest that LSD1 may be involved in carcinogenesis and progression with promising therapeutic potential for epithelial ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 9, 2015 Category: Cancer & Oncology Authors: Cong ChenJing GeQibin LuGuoqiang PingChunqing YangXuefeng Fang Source Type: research
M-CSF in a new biomarker panel with HE4 and CA 125 in the diagnostics of epithelial ovarian cancer patients
Conclusions:
These findings suggest a high usefulness of M-CSF in diagnosing the serous sub-type of epithelial ovarian cancer and in discriminating between cancer and non-carcinoma lesions, particularly in new diagnostic panels in combination with CA 125 and HE4 for the detection of EOC in the early stages. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 3, 2015 Category: Cancer & Oncology Authors: Gra¿yna B¿dkowskaS¿awomir ¿awickiEwa GacutaPrzemys¿aw Paw¿owskiMaciej Szmitkowski Source Type: research
MRI for differentiating ovarian endometrioid adenocarcinoma from high-grade serous adenocarcinoma
PurposeTo investigate magnetic resonance imaging (MRI) features for differentiating ovarian endometrioid adenocarcinoma (OEC) from high-grade serous adenocarcinoma (HGSC).Materials and methodsTwenty-three patients with 25 OECs and 93 patients with 139 HGSCs confirmed by surgery and pathology underwent conventional MRI and diffusion-weighted imaging (DWI). The MRI features of the tumors, including laterality, size, shape, configuration, signal intensity, ADC value of solid component, enhancement, ascites, synchronous primary cancer (SPC) of the ovary and endometrium, and clinical stage, were evaluated and compared between t...
Source: Journal of Ovarian Research - April 30, 2015 Category: Cancer & Oncology Authors: Hai LiJin QiangGan XiaShu ZhaoFeng MaSong CaiFeng FengAi Fu Source Type: research
Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells
Conclusion:
Our results suggest the significance of STAT3 activation in the maintenance and survival of ovarian cancer cells. The activated STAT3 signaling is the critical molecular target of resveratrol. Resveratrol would be a promising candidate in the management of ovarian cancers, especially the ones with resistance to conventional therapeutic agents. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 22, 2015 Category: Cancer & Oncology Authors: Li-Xia ZhongHong LiMo-Li WuXiao-Yu LiuMing-Jun ZhongXiao-Yan ChenJia LiuYang Zhang Source Type: research
The clinicopathological significance of miR-1307 in chemotherapy resistant epithelial ovarian cancer
Conclusion:
Our results suggest that miRNA-1307 may play a role in the development of chemoresistance in ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 9, 2015 Category: Cancer & Oncology Authors: Yingying ZhouMin WangJianlei WuZhihui JieShuang ChangTing Shuang Source Type: research
Successful live birth after transfer of blastocyst and frozen blastocyst from rescue ICSI with application of polarized light microscopy for spindle examination on unfertilized eggs
This article aims to report successful live births after transfer of fresh blastocyst or vitrified/warmed blastocyst derived from intracytoplasmic sperm injection (ICSI) on day-1 of unfertilized mature eggs (so-called “rescue ICSI”) with spindle examination using polarized light microscopy. Two couples who had rescue ICSI performed achieved a positive pregnancy result after the transfer of a fresh or vitrified blastocyst. The two pregnancies led to the live births of a healthy baby boy of 2.72 kg and baby girl of 3.4 kg, respectively. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 8, 2015 Category: Cancer & Oncology Authors: Jeong MoonSara HendersonElena Garcia-CerrudoAlina MahfoudhShauna ReinblattWeon-Young Son Source Type: research
OvAge: a new methodology to quantify ovarian reserve combining clinical, biochemical and 3D-ultrasonographic parameters
Conclusions:
OvAge is one of the first reliable attempt to create a new method able to identify a simple, easy to understand and intuitive modality for defining ovarian reserve by combining clinical, biochemical and 3D-ultrasonographic data. Although design data prove a statistical high accuracy of the model, we are going to plan a clinical validation of model reliability in predicting reproductive prognosis and distance to menopause. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 8, 2015 Category: Cancer & Oncology Authors: Roberta VenturellaDaniela LicoAlessia SaricaMaria FalboElio GullettaMichele MorelliErrico ZupiGabriele CeveniniMario CannataroFulvio Zullo Source Type: research
Evidence for induction of a tumor metastasis-receptive microenvironment for ovarian cancer cells in bone marrow and other organs as an unwanted and underestimated side effect of chemotherapy/radiotherapy
Conclusions:
In summary, we propose that a radiochemotherapy-induced, pro-metastatic microenvironment plays an important role in the metastasis of cancer cells that are resistant to treatment. Such cells have characteristics of cancer stem cells and are highly migratory, and simple, intensive, anti-inflammatory treatment by non-steroid agents to suppress induction of pro-metastatic factors after radiochemotherapy would be an interesting anti-metastatic treatment alternative. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 28, 2015 Category: Cancer & Oncology Authors: Pranesh GunjalGabriela SchneiderAhmed IsmailSham KakarMagda KuciaMariusz Ratajczak Source Type: research
Relationship of tumor marker CA125 and ovarian tumor stem cells: preliminary identification
PurposeThe purpose of this study is to identify a prospective association between CA125 and tumorigenic ovarian cancer cells, using the new method of orthotopic transplantation (1).MethodAfter making the surgical ovarian cancer specimen into cell suspension, we separated the tumorigenic cells from the nontumorigenic cancer cells based on cell surface marker (cancer antigen CA125 and lineage markers) expression. We developed a SCID mice model in which the CA125+/ lineage- and CA125-/ lineage- cells were injected into ovarian parenchyma by use of a microinjector. As a measure of effectiveness of tumor-forming, tumor weight, ...
Source: Journal of Ovarian Research - March 28, 2015 Category: Cancer & Oncology Authors: Hui ZhangYongan YangYifeng WangXinping GaoWeiming WangHui LiuHaipeng HeYijuan LiangKun PanHongli WuJunrong ShiHuiling XueLing LiangZhihuci CaiYanfang FanYanyan Zhang Source Type: research
A targeted analysis identifies a high frequency of BRCA1 and BRCA2 mutation carriers in women with ovarian cancer from a founder population
Conclusions:
Our results reaffirm that specific BRCA1 and BRCA2 mutations found previously to recur in French Canadian breast cancer and breast-ovarian cancer families, also recur in women with ovarian cancer not selected for family history of cancer. The high frequency of mutation carriers rationalizes genetic testing of ovarian cancer patients in this demographically defined population. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 27, 2015 Category: Cancer & Oncology Authors: Moria BelangerLena DolmanSuzanna ArcandZhen ShenGeorge ChongAnne-Marie Mes-MassonDiane ProvencherPatricia Tonin Source Type: research
Influence of mouse strain on ovarian tissue recovery after engraftment with angiogenic factor
Conclusions:
Tissue architecture and follicular morphology were better preserved in ovarian tissues grafted in SCID mice in comparison with NOD-SCID mice. Moreover, tissue revascularization was improved in SCID mice by VEGF111 graft treatment. Thus, we consider SCID mice to be the best murine model for studying ovarian tissue xenografts. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 27, 2015 Category: Cancer & Oncology Authors: Maïté FransoletLaurie HenrySoraya LabiedMarie-Caroline MasereelSilvia BlacherAgnès NoëlJean-Michel FoidartMichelle NisolleCarine Munaut Source Type: research
Differential expression of lysosome-associated protein transmembrane-4 beta (LAPTM4B) in granulosa cells of ovarian follicles and in other bovine tissues
The objective of this study was to investigate the expression of bovine LAPTM4B during ovarian follicular development and in various bovine tissues.Methods and resultsNorthern blot analysis revealed a 1.8 kb transcript, with highly variable steady state levels among tissues. RT-PCR analysis showed that LAPTM4B mRNA transcripts were low in granulosa cells of small antral follicles, increased in large dominant follicles, and decreased in ovulatory follicles following injection of human chorionic gonadotropin (hCG; P (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Kalidou NdiayePaul CarrièreJean SiroisDavid SilversidesJacques Lussier Source Type: research
A metabolomic approach to identifying platinum resistance in ovarian cancer
Background:
Acquisition of metabolic alterations has been shown to be essential for the unremitting growth of cancer, yet the relation of such alterations to chemosensitivity has not been investigated. In the present study our aim was to identify the metabolic alterations that are specifically associated with platinum resistance in ovarian cancer. A global metabolic analysis of the A2780 platinum-sensitive and its platinum-resistant derivative C200 ovarian cancer cell line was performed utilizing ultra-high performance liquid chromatography/mass spectroscopy and gas chromatography/mass spectroscopy. Per-metabolite comparis...
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Laila PoissonAdnan MunkarahHala MadiIndrani DattaSharon Hensley-AlfordCalvin TebbeThomas BuekersShailendra GiriRamandeep Rattan Source Type: research
