Reduced expression of SOX7 in ovarian cancer: a novel tumor suppressor through the Wnt/ß-catenin signaling pathway
Conclusions:
The expression of SOX7 correlates with tumor progression as a tumor suppressor, possibly through the Wnt/β-catenin signaling pathway in ovarian cancers, suggesting that SOX7 may be a promising prognostic marker. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 5, 2014 Category: Cancer & Oncology Authors: Huidi LiuZi-Qiao YanBailiang LiSi-Yuan YinQiang SunJun-Jie KouDan YeKelsey FernsHong-Yu LiuShu-Lin Liu Source Type: research
microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells
In this study, we investigated the role of miR-490-3P in the development of drug resistance in ovarian cancer cells.
Methods:
The human ovarian carcinoma cell line A2780 and A2780/Taxol were exposed to paclitaxel in the presence or absence of microRNA 490-3P transfection, after which cell viability were performed by CCK-8 assay. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to assess the mRNA and protein expression levels of GST-π, MDR1 or P-gp.
Results:
Our results showed higher miR-490-3P mRNA expression level in A2780/Taxol cells than in A2780 cells (p (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 31, 2014 Category: Cancer & Oncology Authors: Shuo ChenXi ChenYin-Ling XiuKai-Xuan SunZhi-Hong ZongYang Zhao Source Type: research
microRNA 490-3P enhances the drug-resistance of human ovarian cancer cells
In this study, we investigated the role of miR-490-3P in the development of drug resistance in ovarian cancer cells.
Methods:
The human ovarian carcinoma cell line A2780 and A2780/Taxol were exposed to paclitaxel in the presence or absence of microRNA 490-3P transfection, after which cell viability were performed by CCK-8 assay. Reverse transcription polymerase chain reaction (RT-PCR) and western blotting were used to assess the mRNA and protein expression levels of GST-?, MDR1 or P-gp.
Results:
Our results showed higher miR-490-3P mRNA expression level in A2780/Taxol cells than in A2780 cells (p? (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 31, 2014 Category: Cancer & Oncology Authors: Shuo ChenXi ChenYin-Ling XiuKai-Xuan SunZhi-Hong ZongYang Zhao Source Type: research
Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review
Background:
Sertoli-Leydig cell tumor (SLCT) is a rare sex-cord tumor that usually occurs unilaterally and accounts for (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 28, 2014 Category: Cancer & Oncology Authors: Dalia MoghazyChakradhari SharanMalika NairCassandra RackauskasRobert BurnetteMichael DiamondOmar Al-HendyAyman Al-Hendy Source Type: research
Ovarian tissue cryopreservation followed by Controlled Ovarian Stimulation and pick-up of mature oocytes does not impair the number or the quality of the retrieved oocytes
Conclusion:
OTC before embryo freezing does not impair the number or quality of cryopreserved embryos, but increases fertility preservation potential. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 26, 2014 Category: Cancer & Oncology Authors: Marie-Madeleine DolmansMaria-Laura MarottaCéline PirardJacques DonnezOlivier Donnez Source Type: research
Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells
Conclusions:
These findings altogether suggest that AQP5 regulated multi processes in ovarian carcinogenesis and may be an attractive therapeutic target. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 15, 2014 Category: Cancer & Oncology Authors: ChunXiao YanYunshan ZhuXiao ZhangXuejun ChenWei ZhengJianhua Yang Source Type: research
Stereotactic radiotherapy in epithelial ovarian cancer brain metastases patients
Conclusions:
When considering evidence-based standards of treatment of patients suffering from epithelial ovarian cancer brain metastases, the established clinical factors are suggested to be prognostic. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 15, 2014 Category: Cancer & Oncology Authors: Agata CelejewskaAndrzej TukiendorfLeszek MiszczykKrzysztof Sk¿adowskiJerzy Wydma¿skiKrystyna Trela-Janus Source Type: research
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Background:
Cryopreservation of ovarian tissue has been suggested as an alternative to restore fertility for ovarian failure before chemotherapy.
Methods:
Ovaries of donor FVB/N-Tg (PolII?Luc) Ltc transgenic mice (n?=?5) were cryopreserved and transplanted to the back muscles of recipient FVB/NJNarl wild-type mice that had undergone bilateral oophorectomy. We evaluated the fate of cryopreserved murine ovarian grafts by in vivo bioluminescent imaging (BLI), AMH mRNA expression and follicle counts.
Results:
There were significantly stronger BLI signals in the fresh ovaries than in the frozen?thawed ones. The number of primor...
Source: Journal of Ovarian Research - August 15, 2014 Category: Cancer & Oncology Authors: Chi-Huang ChenShun-Jen TanChii-Ruey Tzeng Source Type: research
Role of nerve growth factor and its TRKA receptor in normal ovarian and epithelial ovarian cancer angiogenesis
In normal ovarian function a controlled angiogenesis is essential. Several growth factors are involved in this process, such as the vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). The angiogenesis process in the normal ovary is a tightly controlled process that occurs in each ovarian cycle. Also, angiogenesis is critical for ovarian cancer development and it is responsible for tumor spread, metastasis and its peritoneal dissemination. Ovarian cancer is the fifth leading cause of cancer death in women and it is distinguished as the most lethal gynecologic cancer. In recent years angiogenesis has bee...
Source: Journal of Ovarian Research - August 10, 2014 Category: Cancer & Oncology Authors: Carolina VeraVerónica TapiaMargarita VegaCarmen Romero Source Type: research
Luteal activity of pregnant rats with hypo-and hyperthyroidism
Background:
Luteal activity is dependent on the interaction of various growth factors, cytokines and hormones, including the thyroid hormones, being that hypo- and hyperthyroidism alter the gestational period and are also a cause of miscarriage and stillbirth. Because of that, we evaluated the proliferation, apoptosis and expression of angiogenic factors and COX-2 in the corpus luteum of hypo- and hyperthyroid pregnant rats.
Methods:
Seventy-two adult female rats were equally distributed into three groups: hypothyroid, hyperthyroid and control. Hypo- and hyperthyroidism were induced by the daily administration of propylthi...
Source: Journal of Ovarian Research - July 12, 2014 Category: Cancer & Oncology Authors: Juneo SilvaNatália OcarinoRogéria Serakides Source Type: research
Identification of differentially methylated genes in the malignant transformation of ovarian endometriosis
Conclusions:
RASSF2, RUNX3, GSTZ1, CYP2A, GBGT1, NDUFS1, SPOCK2, ADAM22, and TRIM36 were candidate genes for malignant transformation of ovarian EMS and epigenetic inactivation of RASSF2 by promoter hypermethylation is an early event in malignant transformation of ovarian EMS. The screen results were reliable and worthy of further study. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 10, 2014 Category: Cancer & Oncology Authors: Fang RenDan-Bo WangTong LiYing-Han ChenYan Li Source Type: research
Brachial-to-ankle pulse wave velocity as an independent prognostic factor for ovulatory response to clomiphene citrate in women with polycystic ovary syndrome
Conclusions:
Both metabolic and cardiovascular parameters were predictive for CC resistance in PCOS patients. The measurement of baPWV may be a useful tool to predict ovulation in PCOS patients who receive CC. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 10, 2014 Category: Cancer & Oncology Authors: Toshifumi TakahashiHideki IgarashiShuichiro HaraMitsuyoshi AmitaKoki MatsuoAyumi HasegawaHirohisa Kurachi Source Type: research
Prognostic role of bowel Involvement in optimally cytoreduced advanced ovarian cancer: a retrospective study
Conclusions:
Optimal cytoreduction (R < 0.5cm and R0) is the most important prognostic factor for advanced epithelial ovarian cancer. In the optimally cytoreduced (R < 0.5 and R0) patients, bowel involvement is associated with dismal prognosis for OS both in patients with G1-2 grading and in patients with G3 grading. Bowel involvement in G3 patients, carries instead the same risk of recurrence for PFS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 9, 2014 Category: Cancer & Oncology Authors: Giorgio GiordaAngiolo GadducciEmilio LuciaRoberto SorioValentina BounousFrancesco SopracordevoleAndrea TinelliGustavo BaldassarreElio Campagnutta Source Type: research
