Wnt/beta-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer
Conclusions:
These findings support that WNT/beta-catenin pathway and E-cadherin are important factors in advanced epithelial ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 6, 2014 Category: Cancer & Oncology Authors: Lubomir BodnarAleksandra StanczakSzczepan CierniakMarta SmoterMarzena CichowiczWojciech KozlowskiCezary SzczylikMaciej WieczorekMonika Lamparska-Przybysz Source Type: research
Novel three-dimensional in vitro models of ovarian endometriosis
Conclusions:
To our knowledge, this represents the first report of an in vitro spheroid model of endometriosis. 3D endometriosis models represent valuable experimental tools for studying EEC biology and the development of novel therapeutic approaches. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 6, 2014 Category: Cancer & Oncology Authors: Doerthe BrueggmannClaire TemplemanAnna Starzinski-PowitzNagesh RaoSimon GaytherKate Lawrenson Source Type: research
The effectiveness of dual-phase 18F-FDG PET/CT in the detection of epithelial ovarian carcinoma: a pilot study
Conclusion:
Dual-phase 18F-FDG PET/CT might be considered when preoperative imaging is indeterminate. A larger-scaled, prospective study is needed to verify these results. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 5, 2014 Category: Cancer & Oncology Authors: Jae LeeKyung-Jin MinKyeong SoSungeun KimJin Hong Source Type: research
Exosomes: an overview of biogenesis, composition and role in ovarian cancer
Exosomes are tiny membrane-bound vesicles that are over produced by most proliferating cell types during normal and pathological states. Their levels are up-regulated during pregnancy and disease states such as cancer. Exosomes contain a wide variety of proteins, lipids, RNAs, non-transcribed RNAs, microRNAs and small RNAs that are representative to their cellular origin and shuttle from a donor cell to a recipient cell. From intercellular communication to tumor proliferation, exosomes carry out a diverse range of functions, both helpful and harmful. Useful as biomarkers, exosomes may be applicable in diagnostic assessment...
Source: Journal of Ovarian Research - January 25, 2014 Category: Cancer & Oncology Authors: Allison BeachHuang-Ge ZhangMariusz RatajczakSham Kakar Source Type: research
Low dose of rFSH [100 IU] in controlled ovarian hyperstimulation response: a pilot study
Background:
The initial dose of recombinant Follicle Stimulating Hormone [rFSH] to be used in assisted reproduction treatment depends on several factors, mainly the cause of the infertility and the patient's age. For young patients [ (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 21, 2014 Category: Cancer & Oncology Authors: Caio BarbosaEmerson CordtsAndrea CostaRenato de OliveiraMarina de MendonçaDenise ChristofoliniBianca Bianco Source Type: research
Low dose of rFSH [100 IU] in controlled ovarian hyperstimulation response: a pilot study
Background:
The initial dose of recombinant Follicle Stimulating Hormone [rFSH] to be used in assisted reproduction treatment depends on several factors, mainly the cause of the infertility and the patient's age. For young patients [ (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 21, 2014 Category: Cancer & Oncology Authors: Caio BarbosaEmerson CordtsAndrea CostaRenato de OliveiraMarina de MendonçaDenise ChristofoliniBianca Bianco Source Type: research
Sequence variation among members of the miR-200 microRNA family is correlated with variation in the ability to induce hallmarks of mesenchymal-epithelial transition in ovarian cancer cells
Conclusions:
Our results indicate that although ectopic overexpression of all members of the miR-200 family in mesenchymal-like OC cells results in morphological changes characteristic of MET, the underlying molecular changes and induced drug sensitivities are highly variable and correlated with sequence variation within the seed and non-seed regions of individual family members. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 21, 2014 Category: Cancer & Oncology Authors: Neda JabbariAshley ReavisJohn McDonald Source Type: research
Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network
Conclusions:
In all, 17 TFs, including CREM, ERG, and CREB1 were screened as the cancer related TFs in MFSN. Other TFs, such as BIN1, FOXN3, FOXK1, FOXP2, and ESRRG with high degrees may be inhibited in ovarian cancer. MFSN gave us a new shed light on the mechanism studies in ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 21, 2014 Category: Cancer & Oncology Authors: Huanchun YingJing LyuTianshu YingJun LiShanshan JinJingru ShaoLili WangHongying Xu Source Type: research
Locally existing endothelial cells and pericytes in ovarian stroma, but not bone marrow-derived vascular progenitor cells, play a central role in neovascularization during follicular development in mice
Conclusions:
Locally existing endothelial cells and pericytes in the stroma play a central role in the neovascularization during follicular growth, while bone marrow-derived endothelial cells and pericytes partially contribute to this process. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 21, 2014 Category: Cancer & Oncology Authors: Fumie Kizuka-ShibuyaNobuko TokudaKiyoshi TakagiYasuhiro AdachiLifa LeeIsao TamuraRyo MaekawaHiroshi TamuraTakashi SuzukiYuji OwadaNorihiro Sugino Source Type: research
Gene therapy of ovarian cancer using IL-21-secreting human umbilical cord mesenchymal stem cells in nude mice
Conclusion:
These results clearly indicate a safety and usability of hUCMSCs-LV- IL-21 in ovarian cancer gene therapy, suggesting the strategy may be a promising new method for clinical treatment of ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 20, 2014 Category: Cancer & Oncology Authors: Yunxia ZhangJing WangMulan RenMiao LiDengyu ChenJunsong ChenFangfang ShiXiaoying WangJun Dou Source Type: research
Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?
Background:
One of the suggest strategy for patients with repeated implantation failure (RIF) is zygote intrafallopian transfer (ZIFT). However, no data exist regarding to the issue of when and under which circumstances should ZIFT be offered to patients with RIF? We therefore aimed to examine whether repeated implantation failure (RIF) patients characteristics or their previous controlled ovarian hyperstimulation (COH) variables may differentiate between those who will conceive following a ZIFT cycle and those who will not.
Methods:
Forty seven consecutive women admitted to our IVF unit during a 7 year period, who underwe...
Source: Journal of Ovarian Research - January 20, 2014 Category: Cancer & Oncology Authors: Itai GatJacob LevronGil YerushalmiJehoshua DorMasha BrengauzRaoul Orvieto Source Type: research
Suppression of GNAI2 message in ovarian cancer
Conclusion:
These data strongly implicate GNAI2 as a critical regulator of oncogenesis and an upstream driver of cancer progression in OvCa. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 14, 2014 Category: Cancer & Oncology Authors: John RaymondKathryn AppletonJennifer PierceYuri Peterson Source Type: research
Synchronous adrenal metastasis and an inferior vena cava tumor thrombus from an ovarian carcinoma
A 60-year-old woman presented with synchronous adrenal metastasis and an inferior vena cava tumor thrombus in the adrenal vein that developed from an ovarian carcinoma. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, and right adrenalectomy with caval tumor thrombectomy for treatment. Microscopic examination revealed a clear cell ovarian carcinoma and a metastatic adrenal tumor. The patient is clinically free of disease after 6 years of follow-up. There have been no reports of synchronous adrenal metastasis with an inferior vena cava thrombus that developed from an ovarian carcinoma. As...
Source: Journal of Ovarian Research - January 13, 2014 Category: Cancer & Oncology Authors: Hiroyuki TokueAzusa TokueYoshito Tsushima Source Type: research
Inhibitory effects of aromatase inhibitor on estrogen receptor-alpha positive ovarian cancer in mice
Conclusions:
Letrozole was effective for ovarian cancers with abundant expression of ERalpha. Inhibition of angiogenesis and of ascites production appeared to contribute to prolongation of the survival period. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 10, 2014 Category: Cancer & Oncology Authors: Hachidai HirakawaYoshihito YokoyamaHidemi YoshidaHideki Mizunuma Source Type: research
Seasonal changes in expression of nerve growth factor and its receptors TrkA and p75 in the ovary of wild ground squirrel (Citellus dauricus Brandt)
The aim of this study was to investigate the presence of nerve growth factor (NGF) and its receptors tyrosine kinase A (TrkA) and p75 in the ovaries of the wild ground squirrels during the breeding and nonbreeding seasons. In the breeding period, NGF, TrkA and p75 were immunolocalized in granulosa cells, thecal cells, interstitial cells and luteal cells whereas in the nonbreeding period, both of them were detected only in granulosa cells, thecal cells and interstitial cells. Stronger immunostaining of NGF, TrkA and p75 were observed in granulosa cells, thecal cells and interstitial cells in the breeding season compared to ...
Source: Journal of Ovarian Research - January 9, 2014 Category: Cancer & Oncology Authors: Ben LiXia ShengLihong BaoShiyang HuangQinglin LiYuning LiuYingying HanGen WatanabeKazuyoshi TayaQiang Weng Source Type: research
