Immunoexpression of aromatase cytochrome P450 and 17ß-hydroxysteroid dehydrogenase in women¿s ovaries after menopause
Conclusion:
Demonstration of the activity of the key enzymes of ovarian steroidogenesis, CYP 19 and 17β-HSD, confirms steroidogenic activity in the ovaries of postmenopausal women. Nevertheless, ovarian steroidogenic activity decreases with time, and its significant decrease occurs 10 years after menopause. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 10, 2014 Category: Cancer & Oncology Authors: Agnieszka BrodowskaJacek BrodowskiMaria Laszczy¿skaSylwia S¿uczanowska-G¿¿bowskaBogdan RumianowskiIwona RotterAndrzej StarczewskiMariusz Ratajczak Source Type: research
Immunoexpression of aromatase cytochrome P450 and 17beta-hydroxysteroid dehydrogenase in women's ovaries after menopause
Conclusion:
Demonstration of the activity of the key enzymes of ovarian steroidogenesis, CYP 19 and 17beta- HSD, confirms steroidogenic activity in the ovaries of postmenopausal women. Nevertheless, ovarian steroidogenic activity decreases with time, and its significant decrease occurs 10 years after menopause. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 10, 2014 Category: Cancer & Oncology Authors: Agnieszka BrodowskaJacek BrodowskiMaria Laszczy¿skaBogdan RumianowskiSylwia S¿uczanowska-G¿¿bowskaIwona RotterAndrzej StarczewskiMariusz Ratajczak Source Type: research
Fertility drugs, reproductive strategies and ovarian cancer risk
This study provides additional insights regarding the long-term relationships between fertility drugs and risk of ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 8, 2014 Category: Cancer & Oncology Authors: Federica TomaoGiuseppe Lo RussoGian Paolo SpinelliValeria StatiAlessandra Anna PreteNatalie PrinziMarsela SinjariPatrizia ViciAnselmo PapaMaria Stefania ChiottiPierluigi Benedetti PaniciSilverio Tomao Source Type: research
The feasibility and clinical effects of dendritic cell-based immunotherapy targeting synthesized peptides for recurrent ovarian cancer
Background:
Despite the increased rate of complete response to initial chemotherapy, most patients with advanced ovarian cancer relapse and succumb to progressive disease. Dendritic cell (DC)-based immunotherapy has been developed as a novel strategy for generating antitumor immunity as part of cancer treatments. The present study aimed to assess the feasibility and clinical effects of DC therapy for recurrent ovarian cancer (ROC).
Methods:
This retrospective study included 56 ROC patients who initially received standard chemotherapy followed by DC-based immunotherapy targeting synthesized peptides at 2 institutions betwee...
Source: Journal of Ovarian Research - May 7, 2014 Category: Cancer & Oncology Authors: Masanori KobayashiAsako ChibaHiromi IzawaEri YanagidaMasato OkamotoShigetaka ShimodairaYoshikazu YonemitsuYuta ShibamotoNoboru SuzukiMasaki Nagaya Source Type: research
Preoperative HE4 and ROMA values do not improve the CA125 diagnostic value for borderline tumors of the ovary (BOT) - a study of the TOC Consortium
Conclusions:
Both HE4 and CA125 are not reliable biomarkers for the diagnosis of BOT or for predicting the presence of invasive implants. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 7, 2014 Category: Cancer & Oncology Authors: Elena BraicuToon Van GorpMani NassirRolf RichterRadoslav ChekerovKhayal GasimliDirk TimmermanIgnace VergoteJalid Sehouli Source Type: research
Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles
Conclusions:
This study offers multiple candidate genes to be further studied in order to elucidate their role in the modulation of follicular development and, ultimately, of oocyte quality. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 7, 2014 Category: Cancer & Oncology Authors: Gabriel DouvilleMarc-André Sirard Source Type: research
COMT polymorphism influences decrease of ovarian follicles and emerges as a predictive factor for premature ovarian insufficiency
Conclusion:
We were able to demonstrate a strong association between the COMT Val/Met polymorphism and the risk of premature ovarian insufficiency in the Brazilian women evaluated. However, further studies in larger populations are necessary to confirm these findings. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 2, 2014 Category: Cancer & Oncology Authors: Emerson CordtsMonise SantosCarla PelusoErika KayakiBianca BiancoCaio BarbosaDenise Christofolini Source Type: research
Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity
Conclusions:
Antiprogestins carrying a backbone similar to mifepristone are cytotoxic to ovarian cancer cells in a manner that does not depend on the sensitivity the cells have to the standard ovarian cancer chemotherapeutics, cisplatin and paclitaxel. Thus, antiprogestin therapy could be used to treat ovarian cancer cells showing resistance to both platinum and taxanes. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 27, 2014 Category: Cancer & Oncology Authors: Carlos Gamarra-LuquesMaria HaponAlicia GoyenecheCarlos Telleria Source Type: research
Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer
In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women without any malignancy. Genotype-phenotype association revealed that A allele of SNP rs1467465 was more frequent in ovarian cancer patients than in the control group (0.40 vs. 0.33, OR 1.37, 95% CI 1.013-1.853, p = 0.04). After anal...
Source: Journal of Ovarian Research - April 23, 2014 Category: Cancer & Oncology Authors: Susanne SchülerClaus LattrichMaciej SkrzypczakTanja FehmOlaf OrtmannOliver Treeck Source Type: research
Muscle weakness and myalgia as the initial presentation of serous ovarian carcinoma: a case report
Conclusions:
Because of the lack of screening tools for EOC, any clinical findings suggesting its presence are valuable, and the possibility of EOC should be considered in unknown primary malignancies with initial complaints of muscle weakness or myalgia. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 23, 2014 Category: Cancer & Oncology Authors: Kyung-Jin MinYung-Taek OuhHye-Ri HongKyeong-A SoJin Hwa HongJae-Kwan Lee Source Type: research
Evaluation of the effects of hyaluronic acid-carboxymethyl cellulose barrier on ovarian tumor progression
Conclusions:
For the most part, our results support the lack of tumor progression activation due to HA-CMC barrier. We conclude that the benefits gained from using HA-CMC barrier membrane during ovarian cancer surgeries seem to outweigh the potential oncological risks. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 16, 2014 Category: Cancer & Oncology Authors: Laetitia PicaudBenoît ThibaultEliane MeryMonia OualiAlejandra MartinezJean-Pierre DelordBettina CoudercGwenael Ferron Source Type: research
Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells
Conclusions:
These results indicate that EGF stimulates PAF production in ovarian cancer cells in a manner that requires cPLA2. We have also determined that crosstalk can occur bidirectionally between EGFR and PAFR, suggesting that EGF-induced PAF production could result in positive feedback that acts on the PAF-receptor to promote ovarian cancer progression. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 11, 2014 Category: Cancer & Oncology Authors: Yi YuXiaoyan ZhangShanshan HongMingxing ZhangQingqing CaiWei JiangCongjian Xu Source Type: research
Journal of Ovarian Research reviewer acknowledgement 2013
Contributing reviewersThe editors of Journal of Ovarian Research would like to thank all of our reviewers who have contributed to the journal in volume 6 (2013). (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 9, 2014 Category: Cancer & Oncology Authors: Sham KakarStefano PalombaBenjamin TsangDavid Curiel Source Type: research
Effect of exercise intensity on weight changes and sexual hormones (androstenedione and free testosterone) in female rats with estradiol valerate-induced PCOS
Conclusion:
According to weight changes and sexual hormones (Free testosterone and androstenedione) exercise training especially with low intensity may improve symptoms of polycystic ovary syndrome. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 8, 2014 Category: Cancer & Oncology Authors: Maryamosadat MiriHojatolah Karimi JashniFarzaneh Alipour Source Type: research
Krukenberg Tumor presenting as back pain and a positive urine pregnancy test: a case report and literature review
This study aims to describe the unusual case of a 36-year-old woman that presented to the Emergency Department (ED) with back pain and a positive urine pregnancy test. Assessment revealed no intrauterine pregnancy and a small left ovarian cyst. Further investigation showed moderately differentiated gastric adenocarcinoma with distant metastases to the spine. The patient died less than 3 months after her first presentation to the ED. Paraneoplastic syndrome, albeit rare, should be considered in the differential diagnosis of elevated beta-hCG due to the high mortality associated with Krukenberg tumors. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 7, 2014 Category: Cancer & Oncology Authors: Dalia MoghazyOmar Al-HendyAyman Al-Hendy Source Type: research
