A prospective cohort study of dietary indices and incidence of epithelial ovarian cancer
Conclusions:
We did not observe any clear association of three diet quality scores with ovarian cancer risk. Further work should other metrics of evaluating diet quality that may be more relevant cancer risk. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 5, 2014 Category: Cancer & Oncology Authors: Jing XieElizabeth PooleKathryn TerryTeresa FungBernard RosnerWalter WillettShelley Tworoger Source Type: research
The transcriptome of corona radiata cells from individual M¿¿ oocytes that after ICSI developed to embryos selected for transfer: PCOS women compared to healthy women
Background:
Corona radiata cells (CRCs) refer to the fraction of cumulus cells just adjacent to the oocyte. The CRCs are closely connected to the oocyte throughout maturation and their gene expression profiles might reflect oocyte quality. Polycystic ovary syndrome (PCOS) is a common cause of infertility. It is controversial whether PCOS associate with diminished oocyte quality. The purpose of this study was to compare individual human CRC samples between PCOS patients and controls.
Methods:
All patients were stimulated by the long gonadotropin-releasing hormone (GnRH) agonist protocol. The CRC samples originated from indi...
Source: Journal of Ovarian Research - November 29, 2014 Category: Cancer & Oncology Authors: Marie WissingSi SonneDavid WestergaardKho NguyenKirstine BellingThomas HøstAnne Mikkelsen Source Type: research
The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer
Background:
The human RECQ DNA helicase family is involved in genomic stability. Gene mutations of RECQL2, RECQL3, and RECQL4 are associated with genetic disorders and induce early aging and carcinogenesis. Although previous studies have reported that the level of RECQL1 expression is correlated with the prognosis of some of malignancies, the function of RECQL1 is not yet clarified. The present study aimed to examine the relationship between prognosis and the level of RECQL1 expression in epithelial ovarian cancer (EOC), and to identify the role of RECQL1 in EOC cells.
Methods:
The level of RECQL1 expression was determined...
Source: Journal of Ovarian Research - November 26, 2014 Category: Cancer & Oncology Authors: Yoko MatsushitaYoshihito YokoyamaHidemi YoshidaYuki OsawaMakito MizunumaTatsuhiko ShigetoMasayuki FutagamiTadaastu ImaizumiHideki Mizunuma Source Type: research
Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3
Conclusion:
We achieved satisfactory anti-tumor activity using trastuzumab plus LMAb1 in trastuzumab-resistant ovarian cancer model. In similar cases, not only acquired but also de novo, good curative effect might be achieved using combined antibody therapy strategies. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 26, 2014 Category: Cancer & Oncology Authors: Wei WangYan ZhangMing LvJiannan FengHui PengJing GengZhou LinTingting ZhouXinying LiBeifen ShenYuanfang MaChunxia Qiao Source Type: research
Interleukin-2 and SOCS-1 proteins involvement in the pathophysiology of severe ovarian hyperstimulation syndrome-a preliminary proof of concept
Conclusions:
The inflammatory response to hCG, leading to dysregulation of Il-2 expression and SOCS activation, might be the culprit of OHSS. Additional large prospective studies are required to elucidate the effect of hCG on patients? inherited inflammatory cascades, which may help discriminating those at risk to develop severe OHSS from those who are not. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 26, 2014 Category: Cancer & Oncology Authors: Raoul OrvietoOlga Dratviman-StorobinskyDaniel LantsbergJigal HaasRoy MashiachYoram Cohen Source Type: research
The level of RECQL1 expression is a prognostic factor for epithelial ovarian cancer
Background:
The human RECQ DNA helicase family is involved in genomic stability. Gene mutations of RECQL2, RECQL3, and RECQL4 are associated with genetic disorders and induce early aging and carcinogenesis. Although previous studies have reported that the level of RECQL1 expression is correlated with the prognosis of some of malignancies, the function of RECQL1 is not yet clarified. The present study aimed to examine the relationship between prognosis and the level of RECQL1 expression in epithelial ovarian cancer (EOC), and to identify the role of RECQL1 in EOC cells.
Methods:
The level of RECQL1 expression was determined...
Source: Journal of Ovarian Research - November 26, 2014 Category: Cancer & Oncology Authors: Yoko MatsushitaYoshihito YokoyamaHidemi YoshidaYuki OsawaMakito MizunumaTatsuhiko ShigetoMasayuki FutagamiTadaastu ImaizumiHideki Mizunuma Source Type: research
The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study
Conclusions:
Ovarian endometriomas per se may damage ovarian reserve, and cystectomy of endometriomas may cause greater damage to ovarian reserve compared with other benign ovarian cysts. The operation-related damage to the ovarian reserve was positively related to whether the endometriomas were bilateral, as well as cyst size (especially for cysts >7?cm), but was negatively related to the preoperative serum AMH level. Age was a negative factor that affected the ovarian reserve. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 26, 2014 Category: Cancer & Oncology Authors: Yuqing ChenHuihui PeiYajie ChangMinghui ChenHaihe WangHongzhe XieShuzhong Yao Source Type: research
Urinary interleukin-1ß levels among gynecological patients
Conclusions:
This pilot study revealed that urinary levels of IL-1 beta are elevated in patients with epithelial OC supporting the thought that inflammation might be associated with cancer progression. Consequently, further studies of urinary IL-1 beta and the identification of an inflammatory profile specific to OC development may be beneficial to reduce the mortality associated with this disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 18, 2014 Category: Cancer & Oncology Authors: Kamisha WooleryMitchel HoffmanJoshua KraftSanto NicosiaAmbuj KumarPatricia Kruk Source Type: research
Urinary interleukin-1ß levels among gynecological patients
Conclusions:
This pilot study revealed that urinary levels of IL-1 beta are elevated in patients with epithelial OC supporting the thought that inflammation might be associated with cancer progression. Consequently, further studies of urinary IL-1 beta and the identification of an inflammatory profile specific to OC development may be beneficial to reduce the mortality associated with this disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 18, 2014 Category: Cancer & Oncology Authors: Kamisha WooleryMitchel HoffmanJoshua KraftSanto NicosiaAmbuj KumarPatricia Kruk Source Type: research
Uterine mast cell tumor: a clinical and cytohistopathological study
Conclusion:
Based on these findings, a diagnosis of poorly-differentiated mast cell tumor was made and data histologic grading was available for tumor. Neoplasm was poorly differentiated or gradeIII. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 7, 2014 Category: Cancer & Oncology Authors: Ali BahramiFariba KhakiShahram ZehtabianJavad CheraghiMehdi RashnavadiMohammad AhmadiMostafa NaderafifSoheil JavaherypourSiamak MohsenzadehEhsan HosseiniHamed MasoudiMehdi Pourzaer Source Type: research
Malignant mixed germ cell tumour of ovary- an unusual combination and review of literature
Conclusion:
Malingnant mixed germ cell tumours of ovary are highly aggressive neoplasm and early intervention and fertility sparing surgery is required for any adolescent girl presenting with rapidly enlarging pelvic mass. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 4, 2014 Category: Cancer & Oncology Authors: Lajya GoyalSharanjit KaurKanwardeep Kawatra Source Type: research
Notch signaling in serous ovarian cancer
Ovarian cancer is the most lethal of all gynecologic malignancies because women commonly present with advanced stage disease and develop chemotherapy refractory tumors. While cytoreductive surgery followed by platinum based chemotherapy are initially effective, ovarian tumors have a high propensity to recur highlighting the distinct need for novel therapeutics to improve outcomes for affected women. The Notch signaling pathway plays an established role in embryologic development and deregulation of this signaling cascade has been linked to many cancers. Recent genomic profiling of serous ovarian carcinoma revealed that Not...
Source: Journal of Ovarian Research - November 4, 2014 Category: Cancer & Oncology Authors: Jolijn GroenewegRosemary FosterWhitfield GrowdonRené VerheijenBo Rueda Source Type: research
Ultrastructural changes in oocytes during folliculogenesis in domestic mammals
The ultrastructural analysis of oocytes and ovarian follicles has been used to evaluate the effects of assisted reproductive techniques, such as cryopreservation or in vitro oocyte maturation. It also benefits the understanding of such complex mechanisms that occur during folliculogenesis. From the beginning of primordial follicles growth until oocyte maturation in preovulatory follicles oocyte cytoplasmic organelles undergo dynamic alterations that reflect physiological changes and development. This review aims to make a retrospective survey of the relevant features of follicles and oocytes ultrastructure, highlighting th...
Source: Journal of Ovarian Research - October 30, 2014 Category: Cancer & Oncology Authors: Fernanda PauliniRenata SilvaJosé RôloCarolina Lucci Source Type: research
