The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer
Conclusions:
The results of the study suggest that HE4 and CA72-4 determination is the best approach to confirm the benign nature of ovarian endometrioma in women with high CA125 levels. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 1, 2013 Category: Cancer & Oncology Authors: Emanuela AnastasiTeresa GranatoRenato FalzaranoPaola StorelliAdele TicinoLuigi FratiPierluigi Benedetti PaniciMaria Grazia Porpora Source Type: research
Treatment reality in elderly patients with advanced ovarian cancer: a prospective analysis of the OVCAD consortium
Background:
Approximately one third of women diagnosed with ovarian cancer is 70 years or older. Information on the treatment reality of these elderly patients is limited.
Methods:
275 patients with primary epithelial ovarian cancer FIGO stage II-IV undergoing cytoreductive surgery and platinum-based chemotherapy were prospectively included in this European multicenter study. Patients =70 years were compared regarding clinicopathological variables and prognosis.
Results:
Median age was 58 years (18--85); 47 patients (17.1%) were 70 years or older. The postoperative 60-day-mortality rate was 2.1% for elderly and 0.4% for yo...
Source: Journal of Ovarian Research - June 28, 2013 Category: Cancer & Oncology Authors: Fabian TrillschLinn WoelberChristine EulenburgIoana BraicuSandrina LambrechtsRadoslav ChekerovEls van NieuwenhuysenPaul SpeiserAlain ZeimetDan Cacsire Castillo-TongNicole ConcinRobert ZeillingerIgnace VergoteSven MahnerJalid Sehouli Source Type: research
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells
Conclusion:
Our findings suggest that, in addition to the known effects on cancer prevention, SFN may also provide antitumor activity in established ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 26, 2013 Category: Cancer & Oncology Authors: Chi-Chang ChangChao-Ming HungYun-Ru YangMon-Juan LeeYi-Chiang Hsu Source Type: research
mEH Tyr113His polymorphism and the risk of ovarian cancer development
Conclusions:
The CC genotype of Tyr113His mEH may confer increased risk of ovarian cancer. These conclusions should be verified in large and well-designed studies. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 6, 2013 Category: Cancer & Oncology Authors: Jian-Hong ZhongZhi-Ming ZhangLe-Qun Li Source Type: research
Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family
Conclusions:
This work thus opens new perspectives for the use of this promising molecule for the treatment of highly chemoresistant ovarian cancer cells and for sensitization of emerging Bcl-xL targeting strategies such as the use of BH3-mimetic molecules. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 5, 2013 Category: Cancer & Oncology Authors: Julie TomasinaAurélie Malzert-FreonFlorence GiffardEmilie BrotinMarie-Hélène LouisEdwige AbeilardSylvain RaultPascal GauduchonLaurent Poulain Source Type: research
Screening of feature genes of the ovarian cancer epithelia with DNA microarray
Conclusion:
The genes related with cell cycle, lipid metabolism and cytoskeletal structure may be the treatment targets for ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 5, 2013 Category: Cancer & Oncology Authors: Huanchun YingJing LvTianshu YingJun LiQing Yang Source Type: research
Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population
IntroductionVitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.ObjectiveTo study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.Material and methodsFokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.
Results:
Serum vitamin D levels were significantly (p (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 26, 2013 Category: Cancer & Oncology Authors: Sudhesna MohapatraAlpana SaxenaGauri GandhiBidhan KonerPrakash Ray Source Type: research
Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population
Conclusion:
Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 26, 2013 Category: Cancer & Oncology Authors: Sudhesna MohapatraAlpana SaxenaGauri GandhiBidhan KonerPrakash Ray Source Type: research
Altered expression of miRNAs in a dihydrotestosterone-induced rat PCOS model
Conclusion:
Our current findings suggest that miRNAs are differentially regulated in hyperandrogenism, a condition possibly involved in the dysregulation of steroid hormone receptors and intra-ovarian factors, and that miRNAs may be involved in the etiology of PCOS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 15, 2013 Category: Cancer & Oncology Authors: Md Munir HossainMingju CaoQi WangJi Young KimKarl SchellanderDawit TesfayeBenjamin Tsang Source Type: research
Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs
This article reviews some of the key findings of our work with the DAP compounds, and compares this to some of the targeted therapies currently used in ovarian cancer therapy. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 11, 2013 Category: Cancer & Oncology Authors: Kellie RathGeorgia McCannDavid CohnBrian RiveraPeriannan KuppusamyKaruppaiyah Selvendiran Source Type: research
Lung cancer diagnosis on ovary mass: a case report
This report focused on the clinical and pathologic diagnostic challenge of distinguishing secondary from primary ovarian neoplasms. Issues on useful immunohistochemical stains are also discussed. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 10, 2013 Category: Cancer & Oncology Authors: Nunzia LositoCono ScaffaMonica CantileGerardo BottiRaffaele CostanzoAngela MannaRenato FrancoStefano Greggi Source Type: research
Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors
We report a special interesting case because this is the first time that this technique is performed successfully in a woman without ovaries combined with growth factors to promote neoangiogenesis. Obviously, the results of the hormonal response come exclusively from the implanted tissue in these special conditions. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 7, 2013 Category: Cancer & Oncology Authors: Justo CallejoCristina SalvadorSantiago González-NuñezLaura AlmeidaLuciano RodriguezLaura MarquésAna VallsJosé Lailla Source Type: research
Bone morphogenetic proteins and the polycystic ovary syndrome
Conclusions:
BMP levels were undetectable in almost all patients. This suggests that with the current sensitivity of the BMP assays, measurement of serum BMP levels is not suitable as a diagnostic tool for PCOS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 30, 2013 Category: Cancer & Oncology Authors: E van HoutenJoop LavenYvonne LouwersAnke McLuskeyAxel ThemmenJenny Visser Source Type: research
Nadir CA-125 level as prognosis indicator of high-grade serous ovarian cancer
This study aimed to explore whether the nadir CA-125 serum levels could predict the durations of overall survival (OS) and progression free survival (PFS) in patients with high-grade serous ovarian cancer (HG-SOC) from the USA and PRC.Materials and methods: A total of 616 HG-SOC patients from the MD Anderson Cancer Center (MDACC, USA) between 1990 and 2011 were retrospectively analyzed. The results of 262 cases from the Jiangsu Institute of Cancer Research (JICR, PRC) between 1992 and 2011 were used to validate the MDACC data. The CA-125 immunohistochemistry assay was performed on 280 tissue specimens. The Cox proportional...
Source: Journal of Ovarian Research - April 25, 2013 Category: Cancer & Oncology Authors: Xia XuYan WangFang WangLizhou JiaYiqin ZhouFei DengJunwei QuBifang ZhouAifeng MengBole FuXiaoxiang ChenZhiying QianJinhua Wang Source Type: research
Developmental potential of human oocytes matured in vitro followed by vitrification and activation
Conclusions:
Oocytes matured in vitro from unstimulated ovaries seem to have limited developmental potential after cryopreservation and artificial activation. Although the outcome of IVM for non-stimulated oocytes is poor, it is currently the only chance besides cryopreservation of ovarian tissue for women for whom ovarian stimulation is not possible due to life circumstances. Based on our preliminary results, we suggest that the use of cryopreserved ovaries for fertility preservation in women with cancer warrants further investigation. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 18, 2013 Category: Cancer & Oncology Authors: Patrick ImeschDavid ScheinerMin XieDaniel FinkErwin MacasRaghvendra DubeyBruno Imthurn Source Type: research
