Gene expression profiling of ovarian carcinomas and prognostic analysis of outcome
Conclusions:
Our study presents an integrated original model of the differentially expression genes related to ovarian cancer progressing, providing the identification of genes relevant for its pathological physiology which can potentially be new clinical markers. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 31, 2015 Category: Cancer & Oncology Authors: Sheng-Yun CaiTian YangYu ChenJing-Wen WangLi LiMing-Juan Xu Source Type: research
MiRNA-149 modulates chemosensitivity of ovarian cancer A2780 cells to paclitaxel by targeting MyD88
Conclusion:
Our findings suggest that miRNA-149 mediates the susceptibility of paclitaxel by regulating MyD88 expression in ovarian cancer cells. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 30, 2015 Category: Cancer & Oncology Authors: Yueping ZhanFenfen XiangRong WuJian XuZhenhua NiJiemin JiangXiangdong Kang Source Type: research
Limitations of three-dimensional power Doppler angiography in preoperative evaluation of ovarian tumors
Conclusions:
3D-PD angiography presented considerable intraobserver variability and low accuracy for identifying false positive results of IOTA simple rules. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 29, 2015 Category: Cancer & Oncology Authors: Liliane SilvestreWellington MartinsFrancisco Candido-dos-Reis Source Type: research
Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer
Conclusions:
TQ enhanced cisplatin-mediated cytoxicity in ovarian cancer cells in vitro and in a mouse syngeneic model, effects associated with increased DNA damage. However, our results strongly caution that TQ treatment alone may have an overall deleterious effect in the immunocompetent host through stimulation of ascites. Since TQ is a potential candidate for future clinical trials in ovarian cancer patients, this finding has considerable potential relevance to the clinic. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 28, 2015 Category: Cancer & Oncology Authors: Andrew WilsonJeanette SaskowskiWhitney BarhamFiona YullDineo Khabele Source Type: research
Identification of miRNAs during mouse postnatal ovarian development and superovulation
Conclusions:
These results suggest the presence of different miRNAs at different stages of ovarian development and superovulation. Potential role of these microRNAs was elucidated using bioinformatics tools in regulation of different pathways, biological functions and cellular components underlying ovarian development and superovulation. These results provide a framework for extended analysis of miRNAs and their roles during ovarian development and superovulation. Furthermore, this study provides a base for characterization of individual miRNAs to discover their role in ovarian development and female fertility. (Source: Jo...
Source: Journal of Ovarian Research - July 8, 2015 Category: Cancer & Oncology Authors: Hamid KhanYi ZhaoLi WangQian LiYu-Ai DuYi DanLi-Jun Huo Source Type: research
A method to investigate the anti-metabolic activity of anti-cancer agents on ovarian cancer cells cultured in a 96-well high throughput format
Conclusions:
The collagen gel in a 96 well plate format was easy to set up and could have potential to identify drug sensitivity in the clinical management of women with platinum resistant ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 4, 2015 Category: Cancer & Oncology Authors: Simon HoggJohn EvansPeter SykesKenny Chitcholtan Source Type: research
Integrative network analysis for survival-associated gene-gene interactions across multiple genomic profiles in ovarian cancer
Conclusions:
We have developed a simple but powerful analysis tool that is able to detect gene-gene interactions associated with clinical outcome on multiple genomic profiles. By being network-based, our approach provides a better insight into the underlying gene-gene interaction mechanisms that affect the clinical outcome of cancer patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 3, 2015 Category: Cancer & Oncology Authors: Hyun-hwan JeongSangseob LeemKyubum WeeKyung-Ah Sohn Source Type: research
Journal of ovarian research reviewer acknowledgement 2014
Contributing reviewersThe editors of Journal of Ovarian Research would like to thank all of our reviewers who have contributed to the journal in Volume 7 (2014). (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 1, 2015 Category: Cancer & Oncology Authors: Sham KakarStefano PalombaBenjamin TsangDavid Curiel Source Type: research
Prognostic value of circulating tumor cells and disseminated tumor cells in patients with ovarian cancer: a systematic review and meta-analysis
Recent studies have shown diagnostic and prognostic values of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in various cancers, including ovarian cancer. We aimed to evaluate the association of CTCs and/or DTCs with the clinical outcomes of ovarian cancer. Clinical studies of CTCs/DTCs of ovarian cancer were included for systematic review and meta-analysis. A total of 236 studies were screened but only 16 qualified studies with 1623 subjects were included. Odds ratio (OR) showed CTCs/DTCs were not significantly associated with serous carcinoma (OR = 0.71 [0.49, 1.05]), lymph node metastasis (OR 1.1...
Source: Journal of Ovarian Research - June 16, 2015 Category: Cancer & Oncology Authors: Long CuiJoseph KwongChi Wang Source Type: research
Lipoic acid decreases Mcl-1, Bcl-x L and up regulates Bim on ovarian carcinoma cells leading to cell death
Conclusions:
Our results reveal novel actions of LA which could explain the anti-tumoral effects of the LA. Therefore, LA seems to be a promising compound for ovarian cancer treatment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 12, 2015 Category: Cancer & Oncology Authors: Perrine KafaraPhilippe IcardMarilyne GuillaminLaurent SchwartzHubert Lincet Source Type: research
Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
Conclusions:
Our results reveal novel actions of LA which could explain the anti-tumoral effects of the LA. Therefore, LA seems to be a promising compound for ovarian cancer treatment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 12, 2015 Category: Cancer & Oncology Authors: Perrine KafaraPhilippe IcardMarilyne GuillaminLaurent SchwartzHubert Lincet Source Type: research
Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial
Background:
The overall incidence of poor ovarian response in IVF cycles has been reported to be between 9 and 24 %. The management of these patients remains a significant challenge in assisted reproduction. The aim of the present study was to evaluate the effect of myo-inositol (MI) on ovarian function in poor responders undergoing ICSI.
Methods:
The study is a prospective controlled observational trial, that involved 72 poor responders included in an ICSI program and divided into two groups; group A: 38 patients who have been assuming MI (4 g) + folic acid (FA) (400 μg) for the previous 3 months before the enrol...
Source: Journal of Ovarian Research - June 12, 2015 Category: Cancer & Oncology Authors: Francesca CaprioMaria D¿EufemiaCarlo TrottaMaria CampitielloRaffaele IannielloDaniela MeleNicola Colacurci Source Type: research
Novel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancer
Conclusions:
Together, our study identifies CRM1 as a valid target in ovarian cancer and provides a basis for the development of S109 in ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 10, 2015 Category: Cancer & Oncology Authors: Xuejiao LiuYulong ChongHuize LiuYan HanMingshan Niu Source Type: research
Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas
This study aimed to determine the frequency of expression of Rb1, P16 and ER in ovarian epithelial tumors by immunohistochemistry.
Results:
Co-expression of all 3 markers studied was seen in 10 % of high grade serous carcinoma (HGSC) and low grade serous carcinoma (LGSC). Coordinate expression of Rb1+ and ER+ in HGSC and LGSC was seen in 67 % of grade 1/2 vs. 44 % of grade three tumors (p (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 5, 2015 Category: Cancer & Oncology Authors: Donna FergusonDaniel LongMegan SmithLaura Craig-OwensJulie MeansOluwole FadareMohamed Desouki Source Type: research
Corifollitropin alfa compared to daily FSH in controlled ovarian stimulation for in vitro fertilization: a meta-analysis
The present study offers a meta-analysis of published randomized controlled trials (RCTs) evaluating the outcomes of in vitro fertilization (IVF) cycles using corifollitropin alfa for controlled ovarian stimulation (COS) in comparison with daily recombinant FSH (rFSH). The study examined seven RCTs including 2138 patients receiving corifollitropin alfa and 1788 women receiving daily rFSH for COS. As a novel aspect, this meta-analysis included two specific subpopulations of IVF patients, i.e. egg donors and poor responders. There were no significant differences between corifollitropin alfa and rFSH with respect to the major...
Source: Journal of Ovarian Research - June 3, 2015 Category: Cancer & Oncology Authors: Stefania FensoreMarco Di MarzioGian Tiboni Source Type: research
