Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study
We report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 29, 2014 Category: Cancer & Oncology Authors: Rossella De CecioMonica CantileFrancesca CollinaLaura MarraClemente SantonastasoCono ScaffaGerardo BottiNunzia Losito Source Type: research
Aquaporin 5 expression is altered in ovarian tumors and ascites-derived ovarian tumor cells in the chicken model of ovarian tumor
The objective of this study was to determine cellular localization of aquaporin 5 (AQP5) in the ovarian tumors of chicken, a preclinical model for human ovarian tumor and to determine if AQP5 mRNA and protein expression levels in cancerous chicken ovaries and in ascites-derived chicken ovarian cancer (COVCAR) cell lines are different from normal ovaries and normal ovarian surface epithelial (NOSE) cells, respectively.
Methods:
Immunohistochemical staining was performed to determine the localization of AQP5-immunoreactive (ir) cells in normal and cancerous ovaries. To determine AQP5 mRNA and protein concentrations in cancer...
Source: Journal of Ovarian Research - October 25, 2014 Category: Cancer & Oncology Authors: Anupama TiwariJill HadleyRamesh Ramachandran Source Type: research
Expression and molecular consequences of inhibition of estrogen receptors in granulosa cells of bovine follicles
Conclusions:
Our findings indicate that: both ESR1 and ESR2 are regulated during follicular deviation and dominance in cattle and in response to FSH treatment, and ESRs are required for normal gene expression and development of the dominant follicle. Furthermore, we have validated an in vivo model to study estrogen signaling during follicular development that allows paracrine signaling between different follicular cells in a physiological endocrine environment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 23, 2014 Category: Cancer & Oncology Authors: Monique RovaniBernardo GasperinGustavo IlhaRogério FerreiraRodrigo BohrerRaj DuggavathiVilceu BordignonPaulo Gonçalves Source Type: research
Dehydroepiandrosterone improves follicular fluid bone morphogenetic protein-15 and accumulated embryo score of infertility patients with diminished ovarian reserve undergoing in vitro fertilization: a randomized controlled trial
Conclusions:
These observations confirm the beneficial effect of DHEA for infertility patients with diminished ovarian reserve.Trial registrationChiCTR-TRC-14005002 (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 21, 2014 Category: Cancer & Oncology Authors: Huan ZhangPing XuJuan WuWei ZouXia XuXia CaoLian Wei Source Type: research
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
Conclusions:
Our study suggests that SRT1720 may improve the follicle pool reserve in HF diet-induced obese female mice via activating SIRT1 signaling and suppressing mTOR signaling, thus extending the ovarian lifespan. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 21, 2014 Category: Cancer & Oncology Authors: Xiao-Ling ZhouJin-Jie XuYan-Hong NiXiao-Chun ChenHong-Xia ZhangXing-Mei ZhangWei-Juan LiuYu-Cai FuLi-Li Luo Source Type: research
A pilot study to search possible mechanisms of ultralong gonadotropin-releasing hormone agonist therapy in IVF-ET patients with endometriosis
Conclusions:
Ultralong GnRHa therapy reduces the detrimental effects of cytotoxic cytokines and oxidative stress in the ovary in patients with endometriosis. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 21, 2014 Category: Cancer & Oncology Authors: Hiroshi TamuraAkihisa TakasakiYasuhiko NakamuraFumitaka NumaNorihiro Sugino Source Type: research
Association of Gly972Arg variant of insulin receptor subtrate-1 and Gly1057Asp variant of insulin receptor subtrate-2 with polycystic ovary syndrome in the Chinese population
Conclusions:
In this study, we found significant association of the variant of IRS-2 gene as well as the interaction of IRS-1 and IRS-2 genes with PCOS, especially in non-obese women. Women with IRS-2 homozygous Asp variant may be considered as a risk factor for PCOS that needs early detection to prevent further complication in the Chinese population from Taiwan. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 14, 2014 Category: Cancer & Oncology Authors: Ming-Wei LinMei-Feng HuangMeng-Hsing Wu Source Type: research
4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expression
Conclusions:
These results suggest that 4-MU exerts its antitumor effect on ovarian cancer through suppressing TP expression. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 11, 2014 Category: Cancer & Oncology Authors: Ryosuke TamuraYoshihito YokoyamaHidemi YoshidaTadaatsu ImaizumiHideki Mizunuma Source Type: research
The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel
Conclusions:
Our data gained invaluable insights of the antagonistic mechanisms of DEX on PTX-induced cancer cell death and may provide new methods of using DEX as antineoplastic drugs or agents in the clinical treatment for ovarian cancer patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 30, 2014 Category: Cancer & Oncology Authors: Wenjing HouJianhua GuanHuan LuQian DongYuhong HanRong Zhang Source Type: research
The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel
Conclusions:
Our data gained invaluable insights of the antagonistic mechanisms of DEX on PTX-induced cancer cell death and may provide new methods of using DEX as antineoplastic drugs or agents in the clinical treatment for ovarian cancer patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 30, 2014 Category: Cancer & Oncology Authors: Wenjing HouJianhua GuanHuan LuQian DongYuhong HanRong Zhang Source Type: research
Lipid index changes in the blood serum of patients with hyperplastic and early neoplastic lesions in the ovaries
Conclusions:
The lipid index WL proved useful in diagnosing ovarian neoplasm (simple cysts and teratoma adultum) and in monitoring the postoperative period. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - September 27, 2014 Category: Cancer & Oncology Authors: Miko¿aj KarmowskiKrzysztof SobiechJacek MajdaPiotr RubiszStanis¿aw HanAndrzej Karmowski Source Type: research
Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation
In this study, we report an 80-year-old woman with a granulosa cell tumor arising from ovary. She presented with a huge pelvic mass with postmenopausal bleeding. No obvious intraperitoneal tumor implants were observed during operation. Final diagnosis was granulosa-theca cell tumor without capsule invasion. No recurrent disease was noted during 3-year post-operation follow-up period. Molecular studies showed a heterozygous FOXL2 402C > G mutation in the tumor by direct gene sequencing. In addition, DNA replication error, on analysis of the lengths of CAG repeats in androgen receptor gene, revealed defective DNA mismatc...
Source: Journal of Ovarian Research - September 6, 2014 Category: Cancer & Oncology Authors: Wen-Chung WangYen-Chein Lai Source Type: research
KRAS mutation in adenocarcinoma of the gastrointestinal type arising from a mature cystic teratoma of the ovary
We present two cases of perimenopausal female pateints with mature cystic teratoma of single ovary, while local adenocarcinoma arising in the MCT. The malignancies showed immunohistochemical features of intestinal differentiation, such as strong positivity for CDX-2, villin and CK-20, and negativity for CK-7. Furthermore, the mutation analysis of molecular alteration revealed a KRAS gene mutation in the intestinal adenocarcinoma part, extending into benign intestinal-type epithelium linings. Yet the mutation was not present in the epidermal component of the teratoma. We present these as two unique cases of mucinous adenoca...
Source: Journal of Ovarian Research - September 6, 2014 Category: Cancer & Oncology Authors: Yan LiRuiguang ZhangDanzhen PanBangxing HuangMixia WengXiu Nie Source Type: research
Molecular pathogenesis in granulosa cell tumor is not only due to somatic
In this study, we report an 80-year-old woman with a granulosa cell tumor arising from ovary. She presented with a huge pelvic mass with postmenopausal bleeding. No obvious intraperitoneal tumor implants were observed during operation. Final diagnosis was granulosa-theca cell tumor without capsule invasion. No recurrent disease was noted during 3-year post-operation follow-up period. Molecular studies showed a heterozygous FOXL2 402C?>?G mutation in the tumor by direct gene sequencing. In addition, DNA replication error, on analysis of the lengths of CAG repeats in androgen receptor gene, revealed defective DNA mismatch re...
Source: Journal of Ovarian Research - September 6, 2014 Category: Cancer & Oncology Authors: Wen-Chung WangYen-Chein Lai Source Type: research
