HCG (1500IU) administration on day 3 after oocytes retrieval, following GnRH-agonist trigger for final follicular maturation, results in high sufficient mid luteal progesterone levels - a proof of concept
Conclusions:
hCG luteal rescue should be offered 3 days after oocytes retrieval only to those patients with no signs of early moderate OHSS. Further studies are required to elucidate the appropriate regimen of luteal HCG administration in patients undergoing final follicular maturation with GnRH-agonist. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 3, 2014 Category: Cancer & Oncology Authors: Jigal HaasAlon KedemRonit MachtingerShir DarAriel HourvitzGil YerushalmiRaoul Orvieto Source Type: research
Females transplanted with ovaries subjected to hypoxic preconditioning show impair of ovarian function
Conclusion:
The hypoxic preconditioning in vitro was not beneficial to the graft and worsened their viability, compromising its functionality or delaying the return of this. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 20, 2014 Category: Cancer & Oncology Authors: Luciana DamousJuliana NakamutaJosé Soares-JrGustavo MacielRicardo SimõesEdna MonteroJosé KriegerEdmund Baracat Source Type: research
Metastatic ovarian papillary cystadenocarcinoma to the small intestine serous surface: report of a case of high-grade histopathologic malignancy
Ovarian cystadenocarcinoma is characterized by marked heterogeneity and may be composed of an admixture of histologic growth patterns, including acinar, papillary and solid. In the present study, a case of isolated small intestine metastasis of ovarian papillary cystadenocarcinoma was reported. A 7-year-old female mixed-breed dog presented with a mass in the left upper quadrant with progressive enlargement of the abdomen, periodic bloody discharge from the vulva and incontinence. The tumor was histologically characterized by the presence of cysts and proliferation of papillae, both lined by single- or multi-layered pleomor...
Source: Journal of Ovarian Research - March 17, 2014 Category: Cancer & Oncology Authors: Fariba KhakiJavad JavanbakhtSamieh SharifzadMohammad GharagozlouFarshid KhadivarJavad ManeshSeyed HosseiniAli AnissianSeyed TouniAlireza GilvariFatemeh Abdi Source Type: research
Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome
Conclusions:
Copeptin appeared to have an important role in metabolic response and subsequent development of atherosclerosis in insulin resistant, hyperandrogenemic PCOS patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 14, 2014 Category: Cancer & Oncology Authors: Ba¿ak KarbekMustafa ÖzbekMelia KaraköseOya TopalogluNujen BozkurtEvrim Cak¿rMuyesser AslanTuncay Deliba¿¿ Source Type: research
Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse
Conclusion:
We conclude that hyperandrogenization (PCOS) by DHEA diminishes ovarian Rac1 and Vav expression and activity along with an increase in expression of Caveolin1. Further, the levels of intra-ovarian 17beta-estradiol and inhibin B were also found to be elevated in the polycystic ovary. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 14, 2014 Category: Cancer & Oncology Authors: Vineet MauryaSangappa ChadchanVijay KumarSahil MahfoozArchana SinghSingh RajenderRajesh Jha Source Type: research
Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer
Conclusions:
The immunological response to Hsp60/65 is increased in early clinical stages of ovarian cancer and the level of anti-hsp60/65 antibodies may be then a helpful diagnostic marker. Even antibodies against highly homologous Hsps may be cross-reactive only partially and differ by some functional properties. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 11, 2014 Category: Cancer & Oncology Authors: Piotr BodzekRobert PartykaAleksandra Damasiewicz-Bodzek Source Type: research
Lower extremity edema in patients with early ovarian cancer
Conclusions:
Although a significant proportion of patients with ovarian cancer have LEE after surgery, most are not aware of lymphedema until they develop. Education and analyses for LEE and lymphedema are needed in patients with ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 7, 2014 Category: Cancer & Oncology Authors: Myong LimJeong LeeByung NamSang-Soo SeoSokbom KangSang-Yoon Park Source Type: research
Proteomic identification of fucosylated haptoglobin alpha isoforms in ascitic fluids and its localization in ovarian carcinoma tissues from Mexican patients
Conclusions:
Increased numbers of highly fucosylated Haptoglobin alpha isoforms in ascitic fluids and the presence of fucosylated Haptoglobin in tumor tissues of ovarian cancer Mexican patients associated with advanced stages of the disease, reinforce the potential of fucosylated Haptoglobin alpha isoforms to be characterized as biomarkers for disease progression. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 27, 2014 Category: Cancer & Oncology Authors: Olga Garibay-CerdenaresVerónica Hernández-RamírezJuan Osorio-TrujilloMagdalena Hernández-OrtízDolores Gallardo-RincónDavid Cantú de LeónSergio Encarnación-GuevaraJulio Villegas-PinedaPatricia Talamás-Rohana Source Type: research
Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer
Conclusions:
This study provides a first demonstration of PIGR expression in human fallopian tubes, primary EOC tumours and metastases. High tumour-specific expression of PIGR was found to be associated with a favourable prognosis in unadjusted, but not in adjusted, analysis. These findings are novel and merit further investigation. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 26, 2014 Category: Cancer & Oncology Authors: Jonna BerntssonSebastian LundgrenBjörn NodinMathias UhlénAlexander GaberKarin Jirström Source Type: research
Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro
Conclusions:
Presence of germ cell nests, Balbiani body-like structures and cytoplasmic streaming extensively described during fetal ovary development, are indeed well recapitulated during in vitro oogenesis in adult OSE cultures along with characteristic expression of stem/germ cell/oocyte markers. Further studies are required to assess the genetic integrity of in vitro derived oocytes before harnessing their clinical potential. Advance in our knowledge about germ cell differentiation from stem cells will enable researchers to design better in vitro strategies which in turn may have relevance to reproductive biology and r...
Source: Journal of Ovarian Research - February 25, 2014 Category: Cancer & Oncology Authors: Seema ParteDeepa BhartiyaHiren PatelVinita DaithankarAnahita ChauhanKusum ZaveriIndira Hinduja Source Type: research
Epicardial adipose tissue thickness and NGAL levels in women with polycystic ovary syndrome
Conclusions:
Thickness of the epicardial adipose tissue can be used to follow the risk of CVD development in obese PCOS cases. However serum NGAL levels do not differ in patients with PCOS and control group. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 16, 2014 Category: Cancer & Oncology Authors: Serap SahinMedine CureYavuz UgurluElif ErgulEmine GurNe¿e AlyildizMehmet Bostan Source Type: research
The MOC31PE immunotoxin reduces cell migration and induces gene expression and cell death in ovarian cancer cells
Conclusion:
The present study demonstrates that MOC31PE may become a new targeted therapy for ovarian cancer and that the MOC31PE anti-cancer effect is potentiated by CsA. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 15, 2014 Category: Cancer & Oncology Authors: Merete WiigerHemaseh BideliØystein FodstadKjersti FlatmarkYvonne Andersson Source Type: research
Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis
Conclusions:
The present findings indicate that resveratrol potentiates the simvastatin-induced inhibitory effect on theca-interstitial cell androgen production, raising the possibility of development of novel treatments of PCOS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 13, 2014 Category: Cancer & Oncology Authors: Israel OrtegaJesus VillanuevaDonna WongAmanda CressAnna SokalskaScott StanleyAntoni Duleba Source Type: research
A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients
Conclusions:
The patients with increased overall or intra-islet M1/M2 TAM ratios presented with an improved 5-year prognosis. Nevertheless, the TAM distribution patterns did not influence the overall outcomes of different ovarian cancer histotypes. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 8, 2014 Category: Cancer & Oncology Authors: Meiying ZhangYifeng HeXiangjun SunQing LiWenjing WangAimin ZhaoWen Di Source Type: research
Wnt/ß-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer
Background:
β-catenin is the key protein in the WNT signalling pathway and it forms adherent junctions together with E-cadherin. In ovarian carcinoma, abnormal expression of β-catenin, E-cadherin and WNT-1 was observed, but their prognostic and predictive role is unclear. The aim of this study was to clarify the prognostic and predictive role of E-cadherin, β-catenin and WNT-1 in advanced epithelial ovarian carcinoma (AEOC).
Methods:
The expression of E-cadherin, β-catenin and WNT-1 was determined by immunohistochemistry in AEOC. The correlation between expression of these proteins and progression-free survival (PFS) a...
Source: Journal of Ovarian Research - February 6, 2014 Category: Cancer & Oncology Authors: Lubomir BodnarAleksandra StanczakSzczepan CierniakMarta SmoterMarzena CichowiczWojciech KozlowskiCezary SzczylikMaciej WieczorekMonika Lamparska-Przybysz Source Type: research
