Fractalkine receptor is expressed in mature ovarian teratomas and required for epidermal lineage differentiation
Conclusions:
Here we demonstrate that CX3CR1 is expressed in both normally (fetal skin) and abnormally (ovarian teratoma) differentiated keratinocytes and is required for cell differentiation into epidermal lineage. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - August 17, 2013 Category: Cancer & Oncology Authors: Lisa RooperHilal GurlerAndre Kajdacsy-BallaMaria Barbolina Source Type: research
Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer
A gene associated with centrosome abnormalities, WDR62, is overexpressed in ovarian cancer cell lines, indicating that it may affect centrosome amplification in ovarian cancer, and could therefore be a new therapeutic target. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 30, 2013 Category: Cancer & Oncology Authors: Yu ZhangYan TianJing-Jing YuJie HeJia LuoSai ZhangCen-E TangYi-ming Tao Source Type: research
Adequacy of ovarian diathermy under ultrasound control: an experimental model
Conclusion:
The experimental animal model described for transvaginal ultrasound-guided ovarian needle cauterization seems to be feasible. The ovaries were successfully cauterized without injuries in needle path and more energy resulted in significantly more thermal lesion. The safety and effectiveness of this technique, theoretically less invasive than current ovarian drilling methods, could be tested in anovulatory women with PCOS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 25, 2013 Category: Cancer & Oncology Authors: Anita PimentelLucia KliemannDaniela BrumFábio LeivasPaulo SanchesEdison CappHelena Corleta Source Type: research
Benign and malignant ovarian steroid cell tumors, not otherwise specified: case studies, comparison, and review of the literature
Ovarian steroid cell tumors, not otherwise specified (NOS) are rare sex cord-stromal tumors of the ovary with malignant potential. So far only a few cases were reported in English literature through the Pubmed search. Here we report two cases of such tumor, one was benign (first case underwent laparoscopic cystectomy) and the other was malignant (died 10 months later after initial diagnosis), both presented with amenorrhea and clinical signs or symptoms of virilization. In malignant case, we provided evidence (tumor embolus) in addition to the reported five characteristics associated with malignancy. On further evaluation,...
Source: Journal of Ovarian Research - July 22, 2013 Category: Cancer & Oncology Authors: Wei JiangXiang TaoFang FangShaofen ZhangCongjian Xu Source Type: research
Follicle stimulating hormone modulates ovarian stem cells through alternately spliced receptor variant FSH-R3
Conclusions:
FSH modulates ovarian stem cells via FSH-R3 to undergo potential self-renewal, clonal expansion as 'cysts' and differentiation into oocytes. OCT-4 and FSHR proteins (required initially to maintain pluripotent state of VSELs and for FSH action respectively) gradually shift from nuclei to cytoplasm of developing oocytes and are later possibly removed by surrounding granulosa cells as the oocyte prepares itself for fertilization. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 20, 2013 Category: Cancer & Oncology Authors: Hiren PatelDeepa BhartiyaSeema PartePranesh GunjalSnehal VedulkarMithun Bhatt Source Type: research
GPER-1 acts as a tumor suppressor in ovarian cancer
Conclusion:
GPER-1 emerges as a new tumor suppressor with unsuspected therapeutic potential for ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 13, 2013 Category: Cancer & Oncology Authors: Tanja IgnatovSaskia ModlMaike ThuligChristine WeißenbornOliver TreeckOlaf OrtmannAna ZenclussenSerban CostaThomas KalinskiAtanas Ignatov Source Type: research
MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial-mesenchymal transition
Conclusion:
These findings from this study suggest that the miR-200c overexpression may be considered a critical approach for the EOC CD117+CD44+CSCs in clinical trials. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 10, 2013 Category: Cancer & Oncology Authors: Dengyu ChenYunxia ZhangJing WangJunsong ChenCuiping YangKai CaiXiaoying WangFangfang ShiJun Dou Source Type: research
Molecular profiling supports the role of epithelial-to-mesenchymal transition (EMT) in ovarian cancer metastasis
Conclusion:
Our results are consistent with a role of EMT in most if not all ovarian cancer metastases and demonstrate that identical morphologies between primary and metastatic cancer samples is insufficient evidence to negate a role of EMT in the metastatic process. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 10, 2013 Category: Cancer & Oncology Authors: Loukia LiliLilya MatyuninaL WalkerStephen WellsBenedict BenignoJohn McDonald Source Type: research
MicroRNA-200c overexpression inhibits tumorigenicity and metastasis of CD117+CD44+ ovarian cancer stem cells by regulating epithelial- mesenchymal transition
Conclusion:
These findings from this study suggest that the miR-200c overexpression may be considered a critical approach for the EOC CD117+CD44+CSCs in clinical trials. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 10, 2013 Category: Cancer & Oncology Authors: Dengyu ChenYunxia ZhangJing WangJunsong ChenCuiping YangKai CaiXiaoying WangFangfang ShiJun Dou Source Type: research
Surgical management and perioperative morbidity of patients with primary borderline ovarian tumor (BOT)
Conclusions:
Irrespective of the surgical approach, surgical management of BOT has acceptable rates of perioperative complications and morbidity. Choice of initial surgical approach can therefore be made independent of complication-concerns. As the recently published large retrospective AGO ROBOT study observed similar oncologic outcome for both approaches, laparoscopy can be considered for staging of patients with BOT if this appears feasible. An algorithm for the surgical management of BOT patients has been developed. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 9, 2013 Category: Cancer & Oncology Authors: Fabian TrillschJan RuetzelUwe HerwigUlrike DoersteLinn WoelberDonata GrimmMatthias ChoschzickFritz JaenickeSven Mahner Source Type: research
An atypical presentation of sporadic ovarian Burkitt¿s lymphoma: case report and review of the literature
Primary non-Hodgkin’s lymphoma of the ovary is a rare occurrence. An ovarian involvement by non-Hodgkin lymphoma (NHL) may include one of the four subtypes of lymphoma: diffuse large B-cell lymphoma, Burkitt’s lymphoma (BL), lymphoblastic lymphoma or anaplastic large cell lymphoma. Burkitt’s lymphoma is a rare entity with a specific poorly differentiated pattern.Most women experience an ovarian BL with abdominal pelvic pain, abnormal vaginal bleeding, bowel obstruction, urinary frequency, incontinence and abdominal mass. Sometimes these warning signs may be absent, causing a late and more difficult diagnosis.Here we ...
Source: Journal of Ovarian Research - July 4, 2013 Category: Cancer & Oncology Authors: Paola BianchiFrancesco TorciaMarta VitaliGiuliana CozzaMarco MatteoliValentina Giovanale Source Type: research
An atypical presentation of sporadic ovarian Burkitt's lymphoma: case report and review of the literature
Primary non-Hodgkin's lymphoma of the ovary is a rare occurrence. An ovarian involvement by non-Hodgkin lymphoma (NHL) may include one of the four subtypes of lymphoma: diffuse large B-cell lymphoma, Burkitt's lymphoma (BL), lymphoblastic lymphoma or anaplastic large cell lymphoma. Burkitt's lymphoma is a rare entity with a specific poorly differentiated pattern.Most women experience an ovarian BL with abdominal pelvic pain, abnormal vaginal bleeding, bowel obstruction, urinary frequency, incontinence and abdominal mass. Sometimes these warning signs may be absent, causing a late and more difficult diagnosis.Here we report...
Source: Journal of Ovarian Research - July 4, 2013 Category: Cancer & Oncology Authors: Paola BianchiFrancesco TorciaMarta VitaliMariangela LombardiValentina Giovanale Source Type: research
Ovarian masses in children and adolescents in China: analysis of 203 cases
Conclusions:
Abdominal pain is the most common complaint in young patients with adnexal masses. AFP is the most useful diagnostic biomarker of ovarian tumors in young females. Laparoscopic resection of ovarian cysts is an alternative operation approach. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 4, 2013 Category: Cancer & Oncology Authors: Hongqian LiuXiangao WangDonghao LuZhihong LiuGang Shi Source Type: research
The plasma concentration of VEGF, HE4 and CA125 as a new biomarkers panel in different stages and sub-types of epithelial ovarian tumors
Conclusions:
These findings suggest the usefulness of VEGF in the early diagnostics of ovarian cancer, especially in combination with CA125 and HE4, as a new biomarkers panel. Additionally, VEGF is the most useful tool in the diagnostics of locally advanced ovarian cancer without metastases. Investigated cytokine presented similar to HE4 usefulness in differentiation of OC according to its histopathlogical sub-type, and could be used especially in the diagnostics of endometrioid epithelial OC. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - July 2, 2013 Category: Cancer & Oncology Authors: S¿awomir ¿awickiGra¿yna B¿dkowskaEwa Gacuta-SzumarskaMaciej Szmitkowski Source Type: research
Occult leydig cell tumour and androgen-receptor positive breast cancer in a woman with severe hyperandrogenism
Leydig cell tumours represent more than 75% of all testosterone-secreting ovarian masses. These benign tumours are frequently occult or very small, but cause dramatic virilization. Chronic hyperandrogenism can also induce systemic complications, which increase morbidity and mortality risk. One of the most obvious effects of increased testosterone levels is polycythemia, a complication which induces dermatologic, osteoarticular and gastrointestinal manifestations and is associated with increased thrombotic risk. However, scientific literature reports few data concerning etiopathogenesis and management of polycythemia in pat...
Source: Journal of Ovarian Research - July 1, 2013 Category: Cancer & Oncology Authors: Giovanna SaracenoValeria BarresiFrancesco TrimarchiSalvatore Cannavo Source Type: research
