Retraction Note: Investigation of the hub genes and related mechanism in ovarian cancer via bioinformatics analysis
No description available (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Ling-jie FuBing Wang Source Type: research
Retraction Note: The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induced by paclitaxel
No description available (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Wenjing HouJianhua GuanHuan LuQian DongYuhong HanRong Zhang Source Type: research
Retraction Note: Risk miRNA screening of ovarian cancer based on miRNA functional synergistic network
No description available (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Huanchun YingJing LyuTianshu YingJun LiShanshan JinJingru ShaoLili WangHongying Xu Source Type: research
Retraction Note: Gene-gene interaction network analysis of ovarian cancer using TCGA data
No description available (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 26, 2015 Category: Cancer & Oncology Authors: Huanchun YingJing LvTianshu YingShanshan JinJingru ShaoLili WangHongying XuBin YuanQing Yang Source Type: research
The correlation of aromatase activity and obesity in women with or without polycystic ovary syndrome
This study aimed to investigate the effect of polycystic ovary syndrome (PCOS) on the association of aromatase activity assessed by estradiol-to-testosterone ratio (E2/T) with body mass index (BMI) in women.
Methods:
This was a cohort study in five centers for reproductive medicine in China. Data were collected from July 2012 to December 2013. PCOS patients (n = 785) and non PCOS, healthy, age-matched controls (n = 297) were included. Plasma sex hormones including estradiol (E2), testosterone (T), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured by ELISA, together with BMI and E2/T bei...
Source: Journal of Ovarian Research - March 22, 2015 Category: Cancer & Oncology Authors: Jie ChenShanmei ShenYong TanDong XiaYanjie XiaYunxia CaoWenjun WangXiaoke WuHongwei WangLong YiQian GaoYong Wang Source Type: research
Maternal and fetal outcome of pregnancy related hypertension in Mettu Karl Referral Hospital, Ethiopia
Background:
Hypertensive disorders of pregnancy are the most common causes of adverse maternal & perinatal outcomes. Such investigations in resource limited settings would help to have great design strategies in preventing maternal and perinatal morbidity and mortality.AimTo determine management outcome and factor associated with pregnancy related hypertensive disorder in Mettu Karl Referral Hospital, Mettu, Ethiopia.MethodA retrospective study deign was conducted at Mettu Karl Referral Hospital from 1st January 2010 to December 1st 2013 by reviewing medical records and logbooks. Descriptive, binary and multiple logistic r...
Source: Journal of Ovarian Research - March 15, 2015 Category: Cancer & Oncology Authors: Eshetu SeyomMubarek AberaMillion TesfayeNetsanet Fentahun Source Type: research
Very small embryonic-like stem cells are the elusive mouse endometrial stem cells- a pilot study
Conclusions:
VSELs are present in normal uterus and also under conditions of atrophy induced by bilateral ovariectomy. Marked increase in EnSCs is associated with endometrial growth and regeneration. Further studies are warranted to define the niche for these stem cells and whether EnSCs arising from the pluripotent VSELs are common progenitors for epithelial and stromal cells or not remains to be addressed. Results of the present study will help in better understanding of endometrial pathologies and their management in the future. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 11, 2015 Category: Cancer & Oncology Authors: Pranesh GunjalDeepa BhartiyaSiddhanath MetkariDhananjay ManjramkarHiren Patel Source Type: research
Expression of the beta-2 adrenergic receptor (ADRB-2) in human and monkey ovarian follicles: a marker of growing follicles?
Conclusions:
The results imply ADRB-2-mediated actions in the development of primate follicles. Drugs interfering with ADRB-2 are used to treat medical conditions and may have unexplored effects in the human ovary. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 7, 2015 Category: Cancer & Oncology Authors: Christoph MerzSabine SallerLars KunzJing XuRichard YeomanAlison TingMaralee LawsonRichard StoufferJon HenneboldFrancis PauGregory DissenSergio OjedaMary ZelinskiArtur Mayerhofer Source Type: research
Preservation of mouse ovarian tissue follicle morphology and ultra-structure after vitrifying in biotechnological protocols
Background:
The aim of the present study was to characterize the morphological and ultrastractural of mouse ovarian tissue with different cryoprotectant solution.ObjectiveAim of this study, is to demonstrae an improved convetional vitrification method on mouse ovarian tissue using different concentrations of ethylene glycol (EG) and/or dimetyl sulfoxide (DMSO) and EG.Materials and methodsMouse ovarian tissue dissected and were randomly assigned to three groups: control, conventional vitrification (CV) and toxicity test. Then ovaries were vitrified by 5%, 10% EG or DMSO CV1-CV4, 5%, 10% EG plus DMSO CV5-CV6 and EG plus DMSO...
Source: Journal of Ovarian Research - March 6, 2015 Category: Cancer & Oncology Authors: Hamid Tayefi NasrabadiMaryam GavamiAbolfazl AkbarzadehRahim BeheshtiDaryosh MohammadnejadAli Abedelahi Source Type: research
Oocyte zona pellucida dysmorphology is associated with diminished in-vitro fertilization success
Background:
Although irregularities in human zona pellucida (ZP) morphology are well described, there is scant literature on the clinical significance of ZP dysmorphology. We, therefore, designed a retrospective cohort trial of ZP dysmorphology to assess the clinical significance of ZP dysmorphology and its affect on IVF outcome. Over the same time period a random sample of 77 cycles of 77 subjects with all normal oocyte morphology were selected as controls.
Methods:
Between July 2006 and December 2010, all fresh non-donor cases performed at a university hospital IVF center were assessed for ZP dysmorphology. ZP dysmorpho...
Source: Journal of Ovarian Research - February 27, 2015 Category: Cancer & Oncology Authors: May-Tal Sauerbrun-CutlerMario VegaAndrzej BreborowiczEric GonzalesDaniel SteinMathew LedermanMartin Keltz Source Type: research
The CROWN Initiative: journal editors invite researchers to develop core outcomes in women¿s health
No description available (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 27, 2015 Category: Cancer & Oncology Authors: Khalid KhanOn behalf of Chief Editors of Journals participating in The CROWN Initiative Source Type: research
Use of aromatase inhibitors in practice of gynecology
Conclusion:
AIs are promising agents in treatment of estrogen dependent disease. However lack of experience, side effects and cost are limiting factors for using these agents in infertility treatment. However there is need for larger, well designed randomized trials to generate robust data in order to establish the true potential of aromatase inhibitors. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 25, 2015 Category: Cancer & Oncology Authors: Betul UsluogullariCandan DuvanCelil Usluogullari Source Type: research
Small-molecule inhibitor of Bcl-2 (TW-37) suppresses growth and enhances cisplatin-induced apoptosis in ovarian cancer cells
Conclusion:
Bcl-2 level positively correlated with sensitivity to cisplain. Treatment with TW-37 was effective alone and in combination with cisplain in bcl-2 overexpressed OC cell lines in vitro. Thus, TW-37 may be a useful therapeutic agent for OCs. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 20, 2015 Category: Cancer & Oncology Authors: Haixia WangZhifeng ZhangXiuping WeiRuizhen Dai Source Type: research
The expression of DBC1/CCAR2 is associated with poor prognosis of ovarian carcinoma
Background:
Recent reports have shown that deleted in breast cancer 1 (DBC1/CCAR2) is an indicator of poor prognosis of various human cancers. However, its expression in ovarian carcinoma has not been reported.
Methods:
We investigated the immunohistochemical expression of DBC1 and BRCA1 and their prognostic significance in 104 ovarian carcinomas. Survival analyses were performed according to the Kaplan-Meier method, as well as univariate and multivariate Cox proportional hazard regression analysis.
Results:
Positive expression of DBC1 and BRCA1 were seen in 63% (66/104) and 44% (46/104) of overall ovarian carcinomas, resp...
Source: Journal of Ovarian Research - February 15, 2015 Category: Cancer & Oncology Authors: Dong ChoHo ParkSee-Hyoung ParkKyoung KimMyoung ChungWoo MoonMyoung KangKyu Jang Source Type: research
Sequential combination therapy with flavopiridol and autocatalytic caspase-3 driven by amplified hTERT promoter synergistically suppresses human ovarian carcinoma growth in vitro and in mice
In this study, we applied it with flavopiridol to investigate their antitumor effect on ovarian cancer in vitro and in vivo.
Methods:
Cell viabilities were determined using Cell Counting Kit 8 and flow cytometry. RT-PCR and immunoblotting assays were used to detect cellular apoptotic activities. Tumor growth and survival of mice bearing tumors were studied.
Results:
Flavopiridol or AdHTVP2G5-rev-casp3 at low dosage alone was mildly cytotoxic in vitro with a viability rate of 86.5 ± 4.7% for 300 nM flavopiridol and 88.9 ± 5.4% for AdHTVP2G5-rev-casp3 (MOI 20). By contrast, significant synergism of their sequential...
Source: Journal of Ovarian Research - December 21, 2014 Category: Cancer & Oncology Authors: Yue SongXing XinXingyue ZhaiZhijun XiaKeng Shen Source Type: research
