First step in developing a 3D biodegradable fibrin scaffold for an artificial ovary
Conclusion:
This study reports two optimal F/T combinations that allow survival and proliferation of isolated human ovarian cells. Further studies are required to determine if such a scaffold will also be a suitable environment for isolated ovarian follicles. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 25, 2013 Category: Cancer & Oncology Authors: Valérie LuyckxMarie-Madeleine DolmansJulie VanackerSarah ScalercioJacques DonnezChristiani Amorim Source Type: research
Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis
Conclusions:
Our studies provide evidence, for the first time, that OPG can attenuate TRAIL-induced apoptosis in a TRAIL binding-independent manner through the activation of integrin/FAK/Akt signaling in OC cells. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 23, 2013 Category: Cancer & Oncology Authors: Denis LaneIsabelle MatteClaude LaplantePerrine Garde-GrangerClaudine RancourtAlain Piché Source Type: research
Targeted gene silencing using a follicle-stimulating hormone peptide-conjugated nanoparticle system improves its specificity and efficacy in ovarian clear cell carcinoma in vitro
Conclusions:
This study indicated that a FSHR-mediated delivery system could mediate the highly selective delivery of siRNA into ovarian cancer cells and that silencing gro-alpha expression could be a potential choice for ovarian cancer treatment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 20, 2013 Category: Cancer & Oncology Authors: Shanshan HongXiaoyan ZhangJun ChenJiabing ZhouYufang ZhengCongjian Xu Source Type: research
Harbin consensus conference and quality of infertility trials: reflections of a scientist on the Italian experience
During the days August 22–24, 2013 has been held in Harbin (China) an International Consensus Conference aimed to improve the quality and the reporting of the randomized controlled trials (RCTs) in infertility and subfertility field. I, as Italian scientist with experience in clinical infertility trials, was invited to have a speech on the Italian experience in RCTs, with particular regard for the surgical trials. Considerations on this subject were particularly interesting to highlight pitfalls and triumphs of research in Italy. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 20, 2013 Category: Cancer & Oncology Authors: Stefano Palomba Source Type: research
Investigating the clinical potential for 14-3-3 zeta protein to serve as a biomarker for epithelial ovarian cancer
Conclusions:
Determination of CA-125 and HE4 serum levels for the determination of the risk of ovarian malignancy algorithm (ROMA) represents a useful tool for the prediction of chemotherapy efficacy for EOC patients. However, levels of 14-3-3 zeta protein were not found to vary significantly as a consequence of treatment. Therefore we question if 14-3-3 zeta protein is a reliable biomarker, which correlates with the clinical behavior of EOC. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 15, 2013 Category: Cancer & Oncology Authors: Ioannis HatzipetrosPeter GoczeTamas KoszegiAkos JarayLaszlo SzeredayBeata PolgarNelli FarkasBalint Farkas Source Type: research
Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models
Conclusions:
The results suggest that the prevention of CTR1 degradation by bortezomib may be playing a major role in increasing the cellular uptake of platinum drugs and platinum-DNA binding level. Furthermore, the generation of oxidative stress appears to be a major contributor to the enhanced cell kill. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 9, 2013 Category: Cancer & Oncology Authors: Zaynab Al-EisawiPhilip BealeCharles ChanJun YuFazlul Huq Source Type: research
Ovarian hyperstimulation syndrome- an optimal solution for an unresolved enigma
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of controlled ovarian hyperstimulation (COH). The syndrome almost always presents either after hCG administration in susceptible patients or during early pregnancy. Despite many years of clinical experience, there are no precise methods to completely prevent severe OHSS, except by withholding the ovulation-inducing trigger of hCG. Recently, COH which combining GnRH antagonist co-treatment and GnRH agonist trigger has become a common tool aiming to eliminate severe early OHSS. However, the observed decrease in implantation and pregnancy rates following this ...
Source: Journal of Ovarian Research - November 5, 2013 Category: Cancer & Oncology Authors: Raoul Orvieto Source Type: research
Comparing long term impact on ovarian reserve between laparoscopic ovarian cystectomy and open laprotomy for ovarian endometrioma
Conclusion(s)After laproscopic ovarian cystecomy for endometrioma all pareameter of ovarian reseve are significantly decreased on long term follow up as compared to open laprotomy. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 2, 2013 Category: Cancer & Oncology Authors: Moustafa ZaitounMohamed ZaitounManal El Behery Source Type: research
The significance of the alteration of 8-OHdG in serous ovarian carcinoma
Conclusion:
Increased 8-OHdG level and decreased expression of hOGG1 in tumor were found in HG-SOC but not LG-SOC. Increased 8-OHdG level in tumor NDA was significantly associated with poorer overall survival and progression-free survival in serous ovarian carcinoma. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 29, 2013 Category: Cancer & Oncology Authors: Xia XuYan WangWenwen GuoYiqing ZhouChunmei LvXiaoxiang ChenKaijiang Liu Source Type: research
Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
Conclusions:
Our findings may suggest a role of LSD1 in the biology of some ovarian tumors. It is of special interest to find a correlation of LSD1 mRNA overexpression with a transcriptomic signature relevant to cancer. Our findings, therefore, prompt further investigation of the role of LSD1 in ovarian cancer, as well as the study of its enzymatic inhibition in animal models for potential therapeutic purposes in the context of this disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 29, 2013 Category: Cancer & Oncology Authors: Sergiy KonovalovIvan Garcia-Bassets Source Type: research
Ovarian Sertoli¿Leydig cell tumors: MRI findings and pathological correlation
Conclusions:
SLCT demonstrate variable MRI morphological appearances. However, the irregularly thickened wall and septa, the moderate T2WI signal intensity and obvious enhancement in the solid components are three MRI features. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 26, 2013 Category: Cancer & Oncology Authors: Song-Qi CaiShu-Hui ZhaoJin-Wei QiangGuo-Fu ZhangXue-Zhen WangLi Wang Source Type: research
Ovarian Sertoli--Leydig cell tumors: MRI findings and pathological correlation
Conclusions:
SLCT demonstrate variable MRI morphological appearances. However, the irregularly thickened wall and septa, the moderate T2WI signal intensity and obvious enhancement in the solid components are three MRI features. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 26, 2013 Category: Cancer & Oncology Authors: Song-Qi CaiShu-Hui ZhaoJin-Wei QiangGuo-Fu ZhangXue-Zhen WangLi Wang Source Type: research
Mosaic pregnancy after transfer of a ¿euploid¿ blastocyst screened by DNA microarray
Conclusions:
This is the first report to indicate a mosaic pregnancy after transfer of a “euploid” blastocyst that was screened by DNA microarray, and the case further confirms that mosaicism is present in human blastocysts produced by in vitro fertilization. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 8, 2013 Category: Cancer & Oncology Authors: Ghassan HaddadWenyin HeJimmy GillCraig WitzCassie WangKhalied KaskarWeihua Wang Source Type: research
Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells
The inhibition of two major anti-apoptotic proteins, Bcl-xL and Mcl-1, appears essential to destroy chemoresistant cancer cells. We have studied their concomitant inhibition, using ABT 737 or siRNA targeting XL1 and citrate, a molecule which reduces the expression level of Mcl-1.Two cisplatin-chemoresistant ovarian cell lines (SKOV3 and IGROV1-R10) were exposed to ABT 737 or siRNA targeting XL1 and citrate at various individual concentrations, or combined. Cell proliferation, cell cycle repartition and nuclear staining with DAPI were recorded. Western blot analyses were performed to detect various proteins implied in apopt...
Source: Journal of Ovarian Research - October 8, 2013 Category: Cancer & Oncology Authors: Hubert LincetPerrine KafaraFlorence GiffardEdwige Abeilard-LemoissonMaryline DuvalMarie-Hélène LouisLaurent PoulainPhilippe Icard Source Type: research
Mosaic pregnancy after transfer of a "euploid" blastocyst screened by DNA microarray
Conclusions:
This is the first report to indicate a mosaic pregnancy after transfer of a "euploid" blastocyst that was screened by DNA microarray, and the case further confirms that mosaicism is present in human blastocysts produced by in vitro fertilization. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - October 8, 2013 Category: Cancer & Oncology Authors: Ghassan HaddadWenyin HeJimmy GillCraig WitzCassie WangKhalied KaskarWeihua Wang Source Type: research
