Impaired uterine artery flow associated with the presence of ovarian endometrioma: preliminary results of a prospective study
Background:
Aim of this prospective, case-control study was to evaluate uterine arteries' blood flow before and after laparoscopic surgery in patients with ovarian endometriosis and its possible correlation with infertility.
Methods:
We prospectively enrolled 110 women of reproductive age; 69 with ovarian endometriomas and scheduled for surgery, and 41 controls. At enrolment, a detailed medical, gynecologic and obstetric history was collected. Fertility and pregnancy desire were assessed. All patients underwent complete physical and gynecologic examination. Transvaginal ultrasound with Doppler color flow was performed to e...
Source: Journal of Ovarian Research - January 8, 2014 Category: Cancer & Oncology Authors: Maria Grazia PorporaFederica TomaoLucia ManganaroDeliar YazdanianEliana FuggettaPierluigi Benedetti PaniciMaria Grazia PiccioniGiuseppe Benagiano Source Type: research
Increased expression of the leptin receptor in human ovaries affected by endometrioma and detection of high levels of leptin in the ovarian endometriomal fluid
Conclusions:
These data suggest that leptin may play an important role in the physiopathology of OE through a modulatory interaction with its active receptor. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 8, 2014 Category: Cancer & Oncology Authors: Carolina ZendronHelder GonçalvesFernanda CavalcanteThiago PereiraAlessandra EvangelistaCristiane RamosMarco Oliveira Source Type: research
A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment
Conclusions:
The modified treatment with a half-dose or early administration of CC significantly increased endometrial thickness in patients with a history of thin endometrium caused by the standard CC regimen. The modified CC treatments in this study can be beneficial for patients with a thin endometrium as a result of standard CC treatment.Trial registration: Clinical Trial Registration Number: UMIN000007959. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 27, 2013 Category: Cancer & Oncology Authors: Akihisa TakasakiHiroshi TamuraToshiaki TaketaniKatsunori ShimamuraHitoshi MoriokaNorihiro Sugino Source Type: research
Induction of a tumor-metastasis-receptive microenvironment as an unwanted and underestimated side effect of treatment by chemotherapy or radiotherapy
There are well-known side effects of chemotherapy and radiotherapy that are mainly related to the toxicity and impaired function of vital organs; however, the induction by these therapies of expression of several pro-metastatic factors in various tissues and organs that in toto create a pro-metastatic microenvironment is still, surprisingly, not widely acknowledged. In this review, we support the novel concept that toxic damage in various organs leads to upregulation in "bystander" tissues of several factors such as chemokines, growth factors, alarmines, and bioactive phosphosphingolipids, which attract circulating normal ...
Source: Journal of Ovarian Research - December 27, 2013 Category: Cancer & Oncology Authors: Mariusz RatajczakTomasz JadczykGabriela SchneiderSham KakarMagda Kucia Source Type: research
Impact of GnRH agonist triggering and intensive luteal steroid support on live-birth rates and ovarian hyperstimulation syndrome: a retrospective cohort study
Conclusions:
GnRHa trigger combined with intensive luteal steroid support in this group of OHSS high risk Asian patients can facilitate fresh embryo transfer, however, in contrast to previous reports the occurrence of late onset OHSS was not completely eliminated. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 26, 2013 Category: Cancer & Oncology Authors: Stamatina IliodromitiVuong LanHo TuongPhung TuanPeter HumaidanScott Nelson Source Type: research
Investigation of the hub genes and related mechanism in ovarian cancer via bioinformatics analysis
Conclusions:
It indicated that ovarian cancer was closely associated to the dysregulation of p53 signaling pathway, drug metabolism, tyrosine metabolism and cell cycle. Besides, we also predicted genes such as CCNE1, CCNB2, CYP3A5 and VEGFA might be target genes for diagnosing the ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 17, 2013 Category: Cancer & Oncology Authors: Ling-jie FuBing Wang Source Type: research
Relative expression of proprotein convertases in rat ovaries during pregnancy
Conclusion:
PC1/3 (PCSK1) and PACE4 (PCSK6) may play an important role in proprotein processing in the ovary during late pregnancy. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 11, 2013 Category: Cancer & Oncology Authors: Simon KwokDamayanti ChakrabortyMichael SoaresGuoli Dai Source Type: research
Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery
Background:
To translate the concept of full-conditioning (FC) from animal experiments to the human, and to evaluate the efficacy for adhesion prevention. FC consisted of decreasing acute inflammation by 86% CO2+ 10% N2O + 4% O2 for the pneumoperitoneum, cooling of the peritoneal cavity, humidification, heparinized rinsing solution and 5 mg of dexamethasone as demonstrated in animal models.
Methods:
A randomized controlled trial (RCT: NCT01344486) comparing standard laparoscopy with full conditioning together with a barrier in a 2/3 ratio in 44 women undergoing deep endometriosis surgery at KULeuven. The primary aim was re...
Source: Journal of Ovarian Research - December 11, 2013 Category: Cancer & Oncology Authors: Philippe KoninckxRoberta CoronaDirk TimmermanJasper VergutsLeila Adamyan Source Type: research
Regulation of angiotensin II type 1 receptor expression in ovarian cancer: a potential role for BRCA1
Conclusions:
These results indicate that BRCA1 may be a potential trigger involved in the transcriptional regulation of AGTR1 in the development of ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 9, 2013 Category: Cancer & Oncology Authors: Fang-Fang BiDa LiChen CaoChun-Yan LiQing Yang Source Type: research
Gene-gene interaction network analysis of ovarian cancer using TCGA data
Conclusion:
our data provides a comprehensive bioinformatics analysis of genes, functions, and pathways which may be involved in the pathogenesis of ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 6, 2013 Category: Cancer & Oncology Authors: Huanchun YingJing LvTianshu YingShanshan JinJingru ShaoLili WangHongying XuBin YuanQing Yang Source Type: research
Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years¿ retrospective study in a developing country
Conclusions:
Sex cord stromal tumors are uncommon ovarian tumors in Pakistani population, with wide age range and diverse histological types having good prognosis. Immunohistochemical markers overlap with epithelial tumors so there is need to distinguish these two. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 5, 2013 Category: Cancer & Oncology Authors: Saroona HaroonAleena ZiaRomana IdreesAisha MemonSaira FatimaNaila Kayani Source Type: research
Ovarian mucinous cystic tumor of borderline malignancy with a mural nodule of anaplastic spindle cell carcinoma: a case report
We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma of both ovaries 9 years before the present history. Image analysis and laboratory data showing a high serum CA19-9 level suggested ovarian malignancy. She underwent bilateral salpingo-oophorectomy with hysterectomy and omentectomy. There was a mural nodule in the ovarian mucinous cystic lesion. Microscopically, the nodule was composed of spindle-shaped cells with severe ...
Source: Journal of Ovarian Research - December 5, 2013 Category: Cancer & Oncology Authors: Hitoshi YamazakiAkiyo MatsuzawaTakashi ShodaHiroyoshi IguchiNoriyuki Kyushima Source Type: research
Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years' retrospective study in a developing country
Conclusions:
Sex cord stromal tumors are uncommon ovarian tumors in Pakistani population, with wide age range and diverse histological types having good prognosis. Immunohistochemical markers overlap with epithelial tumors so there is need to distinguish these two. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - December 5, 2013 Category: Cancer & Oncology Authors: Saroona HaroonAleena ZiaRomana IdreesAisha MemonSaira FatimaNaila Kayani Source Type: research
Estrogen and androgen receptor expression in surface epithelium and inclusion cyst in the ovary of premenopausal and postmenopausal women
Conclusions:
The presence of ER alpha, AR, and GPR30 in the surface epithelial ovarian cells and its derivatives are observed with a proportion that is specific for each receptor. The proportion of expression for these receptors in the epithelial cells of the ovary does not change after menopause. The proportion of ovaries with AR positive epithelial cells in patients with cervical squamous carcinoma is higher compared with other gynecological pathologies. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 27, 2013 Category: Cancer & Oncology Authors: Carmen MendezFlavia Morales-VasquezDelia Perez-MontielMaria GomoraClementina Espinola-ZetinaAzucena Hernandez-MartinezHoracio Lopez-BasaveEnrique Pedernera Source Type: research
MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1
Conclusions:
Our studies suggest a protective role of miR-124 in inhibition of migration and invasion in the molecular etiology of ovarian cancer, and a potentially novel application of miR-124 in the regulation of migration and invasion in EOC. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - November 26, 2013 Category: Cancer & Oncology Authors: Hanwen ZhangQiuyu WangQian ZhaoWen Di Source Type: research
