Serum folate receptor alpha, mesothelin and megakaryocyte potentiating factor in ovarian cancer: association to disease stage and grade and comparison to CA125 and HE4
Conclusions:
FRA has significant potential as a biomarker for ovarian cancer, both as a stand-alone marker and in combination with other known markers for EOC. The lack of correlation between the various markers analyzed in the present study suggests that a panel of markers can aid in the detection and/or monitoring of this disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 17, 2013 Category: Cancer & Oncology Authors: Daniel O¿ShannessyElizabeth SomersLeslie PalmerRobert ThielPankaj OberoiRyan HeathLisa Marcucci Source Type: research
Immature ovarian teratoma with unusual gliomatosis
This study aimed to investigate an unusual case of immature ovarian teratoma with onset of mature glial cells implanted on the contralateral ovary, a challenge in the diagnosis of the second ovarian tumor. We report the case of a 31- yr-old woman, who developed at the age of 16 an immature teratoma in the right ovary that was surgically removed. Six years later mature glial implants were present on the left ovary and six months later at the level of peritoneum that relapsed after other six months. The patient suffered three surgical resections after the initial one. Paraffin sections and immunohistochemical examinations us...
Source: Journal of Ovarian Research - April 16, 2013 Category: Cancer & Oncology Authors: Ancuta Gheorghisan-GalateanuDana TerzeaMara CarsoteCatalina Poiana Source Type: research
Journal of Ovarian Research Reviewer Acknowledgement 2012
Contributing reviewersThe editors of Journal of Ovarian Research would like to thank all of our reviewers who have contributed to the journal in volume 5 (2012). (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 16, 2013 Category: Cancer & Oncology Authors: Sham KakarDavid CurielStefano PalombaBenjamin Tsang Source Type: research
Leiomyosarcoma of the rectum mimicking primary ovarian carcinoma: a case report
Leiomyosarcoma of the rectum is a very rare mesenchymal tumor. Because of its rarity, its diagnosis, treatment, and pathology often present challenges to the clinician. The characteristics of this tumor, such as its anatomical location, heterogeneous solid features on imaging, and nonspecific lower gastrointestinal tract symptoms, can be confused with those of primary ovarian carcinoma. Here, we report the case of a 52-year-old-woman presenting with a low abdominal mass that was later pathologically confirmed to be a rectal leiomyosarcoma. The findings of preoperative ultrasonography, pelvic magnetic resonance imaging, and...
Source: Journal of Ovarian Research - April 15, 2013 Category: Cancer & Oncology Authors: Yung-Taek OuhJin Hwa HongKyung-Jin MinKyeong-A SoJae Kwan Lee Source Type: research
No evidence for PALB2 methylation in high-grade serous ovarian cancer
Conclusion:
Epigenetic silencing by DNA methylation of PALB2 is not a common event in high-grade serous ovarian cancers. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 12, 2013 Category: Cancer & Oncology Authors: Thomas MikeskaKathryn AlsopGillian MitchellDavid BowtellAlexander Dobrovic Source Type: research
ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells
Conclusions:
Receptor sialylation by ST6Gal-I confers a survival advantage for tumor cells in the presence of cisplatin. These collective findings support a role for ST6Gal-I in chemoresistance and highlight ST6Gal-I as a potential therapeutic target for platinum resistant tumors. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 11, 2013 Category: Cancer & Oncology Authors: Matthew SchultzAmanda SwindallJohn WrightElizabeth SztulCharles LandenSusan Bellis Source Type: research
Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage?
Conclusions:
Our results confirm the potential embryonic-like character of small putative stem cells isolated from human adult ovaries and their possible relation to germinal lineage. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 9, 2013 Category: Cancer & Oncology Authors: Irma Virant-KlunMartin StimpfelBranko CvjeticaninEda Vrtacnik-BokalThomas Skutella Source Type: research
Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells
Conclusion:
These findings suggest that PHB regulates granulosa cell apoptosis and steroidogenesis in a follicular stage-dependent manner and that the dysregulation of PHB expression and action may be relevant to ovarian dysfunction. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 8, 2013 Category: Cancer & Oncology Authors: Qi WangArthur LeaderBenjamin Tsang Source Type: research
Serum agonistic autoantibodies against type-1 angiotensin II receptor titer in patients with epithelial ovarian cancer: a potential role in tumor cell migration and angiogenesis
Conclusion:
Taken together, we found that a higher serum AT1-AA titer may be associated with advanced progression of EOC in patients and play an important role in development of EOC by promoting cancer cell migration and angiogenesis. These findings implicate that AT1-AA might be selected as a detectable biomarker and potential therapeutic target in diagnosis and treatment of EOC patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 5, 2013 Category: Cancer & Oncology Authors: Li SongSu-Li ZhangKe-Hua BaiJie YangHai-Yan XiongXiao LiTeng LiuHui-Rong Liu Source Type: research
A pilot study of an exercise & cognitive behavioral therapy intervention for epithelial ovarian cancer patients
Conclusion:
The combined 6-month exercise-cognitive behavioral therapy intervention was associated with significant increases in aerobic fitness in epithelial ovarian cancer patients assessed. These improvements were similar regardless of whether the patient was receiving chemotherapy or under surveillance. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 4, 2013 Category: Cancer & Oncology Authors: Shalini MoonsammyCrissa GugliettiDaniel Santa MinaSarah FergusonJennifer KukSara UrowitzDavid WiljerPaul Ritvo Source Type: research
Stimulation of ovarian stem cells by follicle stimulating hormone and basic fibroblast growth factor during cortical tissue culture
Conclusion:
The present study shows that both FSH and bFGF stimulate stem cells present in OSE and also lead to PF growth initiation. Thus besides being a source of PF, cryopreserved ovarian cortical tissue could also be a source of stem cells which retain the ability to spontaneously differentiate into oocyte-like structures in vitro. Results provide a paradigm shift in the basic understanding of FSH action and also offer a new perspective to the field of oncofertility research. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - April 1, 2013 Category: Cancer & Oncology Authors: Seema ParteDeepa BhartiyaDhananjay ManjramkarAnahita ChauhanAmita Joshi Source Type: research
Clinical governance network for clinical audit to improve quality in epithelial ovarian cancer management
Conclusions:
The differences in terms of treatments provided led the multidisciplinary group to identify reference centers, to promote centralization, to ensure uniform and adequate treatment to patients treated in regional centers and to promote a new audit involving all regional hospitals to a complete review of the all the EOC patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 31, 2013 Category: Cancer & Oncology Authors: Vincenzo Dario MandatoMartino AbratePierandrea De IacoDebora PirilloGino CiarliniMaurizio LeoniGiuseppe ComerciAlessandro VenturaBruno LenziAndrea AmadoriFederica RosatiRuby MartinelloRossana De PalmaChiara VenturaLaura Maria Beatrice BelottiDebora Formis Source Type: research
MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance
Conclusion:
Our findings indicate that ALDH1 is a useful marker for enriching ovarian CSCs, and high expression of ALDH1 and its related miRNAs, particularly miR-23b, miR-27b, miR-424, and miR-503, are significantly implicated in chemoresistance and tumor progression in ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 22, 2013 Category: Cancer & Oncology Authors: Young ParkJu-yeon JeongMi-jung LeeKwang-il KimTae-Heon KimYoung-do KwonChan LeeOak KimHee-Jung An Source Type: research
Longitudinal health-related quality of life assessment: implications for prognosis in ovarian cancer
Conclusions:
This exploratory study provides evidence that an improvement in appetite, constipation and global health scores during the first 3 months of treatment is significantly associated with improved survival time in ovarian cancer. These findings justify serial, systematic assessment of global health, appetite and constipation in ovarian cancer patients being treated, and suggest that modalities designed to improve these functions may be beneficial clinically. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - March 8, 2013 Category: Cancer & Oncology Authors: Digant GuptaDonald BraunEdgar StarenMaurie Markman Source Type: research
CA-125¿indicated asymptomatic relapse confers survival benefit to ovarian cancer patients who underwent secondary cytoreduction surgery
Background:
There is no consensus regarding the management of ovarian cancer patients, who have shown complete clinical response (CCR) to primary therapy and have rising cancer antigen CA-125 levels but have no symptoms of recurrent disease. The present study aims to determine whether follow-up CA-125 levels can be used to identify the need for imaging studies and secondary cytoreductive surgery (CRS).
Methods:
We identified 410 ovarian cancer patients treated at The University of Texas MD Anderson Cancer Center between 1984 and 2011. These patients had shown CCR to primary therapy. Follow-up was conducted based on the sur...
Source: Journal of Ovarian Research - February 13, 2013 Category: Cancer & Oncology Authors: Fang WangYanfen YeXia XuXuehui ZhouJinhua WangXiaoxiang Chen Source Type: research
