Optimized protocol for cryopreservation of human eggs improves developmental competence and implantation of resulting embryos
Conclusions:
These results indicate that blastocyst development is an appropriate measure for egg survival after cryopreservation and frozen eggs have similar developmental potential as fresh eggs if they are frozen with an optimized method. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 13, 2013 Category: Cancer & Oncology Authors: Cassie WangLifeng LiangCraig WitzDan WilliamsJason GriffithJosh SkorupskiGhassan HaddadJimmy GillWeihua Wang Source Type: research
Massive edema of ovary with cytogenetic alteration of chromosome 12q13-15 in adolescent patient: a case report
We report a rare case, very peculiar also for its association with a massive stromal fibromatosis and for the presence, never described, of tumoral areas with CHOP gene translocation, on chromosome 12q13-15. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 7, 2013 Category: Cancer & Oncology Authors: Rossella CecioMonica CantileNicola FortunatoAnnarosaria ChiaraNunzia LositoRenato FrancoGerardo Botti Source Type: research
Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway
Conclusions:
While insulin and IGF are often required for propagation of primary cells, these cytokines may act as potent mitogens to disrupt cell growth, resulting in formation of hyperplastic OSE and decreased follicular integrity as measured by MIS expression and collagen deposition. This may be due partly to altered collagen IV deposition and organization in the ovary in response to insulin and IGF signaling mediated by PI 3-kinase. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 7, 2013 Category: Cancer & Oncology Authors: Shelby KingDimple ModiSharon EddieJoanna Burdette Source Type: research
Establishment of a new representative model of human ovarian cancer in mice
Conclusions:
The model described in this paper accurately mimics the features of ovarian tumor, which may be useful for evaluation of new therapeutics. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 6, 2013 Category: Cancer & Oncology Authors: Jianjun ZhangXinlian ChenGang ShiXiaoyan XieHongqian LiuXuemei ZhangYi LaiYan ZuoZhong ChenShanling LiuHe Wang Source Type: research
Pegylated liposomal doxorubicin in ovarian cancer treatment: A mono-institutional retrospective analysis. Do we still need it?
Conclusions:
No evidence of superiority if PLD was compared to alternative agents was found in this analysis, particularly in the platinum-refractory setting. Our findings indicate a modest therapeutic activity of PLD in OC. Analysis of cost/benefit of PLD in OC is eagerly awaited. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 6, 2013 Category: Cancer & Oncology Authors: Nicoletta StaropoliDomenico CilibertoCirino BottaLucia FiorilloSimona GualtieriAngela SalvinoPierfrancesco TassonePierosandro Tagliaferri Source Type: research
Individualization of the FSH starting dose in IVF/ICSI cycles using the antral follicle count
Conclusions:
The daily FSH dose may be calculated on the basis of age and two markers of ovarian reserve, namely AFC and FSH, with the last two variables being the most significant predictors. The nomogram seems easily applicable during the daily clinical practice. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 6, 2013 Category: Cancer & Oncology Authors: Antonio La MarcaValentina GrisendiSimone GiuliniCindy ArgentoAlessandra TirelliGiulia DondiEnrico PapaleoAnnibale Volpe Source Type: research
Establishment and characterization of a cell line (NOMH-1) originating from a human endometrioid adenocarcinoma of the ovary
Conclusions:
NOMH-1 is the first ovarian endometrioid adenocarcinoma cell line in which CEA and CA19-9 expression have been defined. This newly established cell line should be useful for investigating the characteristics of ovarian endometrioid adenocarcinoma. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - February 4, 2013 Category: Cancer & Oncology Authors: Takashi YamadaTakayoshi KandaHiroshi MoriKaname ShimokawaMitsuo KagawaYuro Shibayama Source Type: research
PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation
Background:
Since ovarian cancer is associated with high frequency of p53 mutation, the availability of p53 reactivation and induction of massive apoptosis (PRIMA-1) offers a possible new therapeutic strategy for overcoming this devastating disease. Although Akt activation is believed to be a determinant in chemoresistance in ovarian cancer, whether Akt plays a role in regulating the effectiveness of PRIMA-1 in sensitizing chemoresistant ovarian cancer cells with p53 mutation to cisplatin (CDDP), remains to be determined.
Methods:
In the present studies, we examined the influence of Akt down-regulation following dominant-n...
Source: Journal of Ovarian Research - January 26, 2013 Category: Cancer & Oncology Authors: Noriko KobayashiMohammadreza AbediniNoriaki SakuragiBenjamin Tsang Source Type: research
Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer
Background:
Epithelial ovarian cancer is one of the leading causes of gynaecological cancer morbidity and mortality in women. Early stage ovarian cancer is usually asymptomatic, therefore, is often first diagnosed when it is widely disseminated. Currently available diagnostics lack the requisite sensitivity and specificity to be implemented as community-based screening tests. The identification of additional biomarkers may improve the diagnostic efficiency of multivariate index assays. The aims of this study were to characterise and compare the ovarian tissue immunohistochemical localisation and plasma concentrations of th...
Source: Journal of Ovarian Research - January 22, 2013 Category: Cancer & Oncology Authors: Ratana LimMartha LappasClyde RileyNiels BorregaardHolger MollerNuzhat AhmedGregory Rice Source Type: research
Her-2/neu expression is a negative prognosticator in ovarian cancer cases that do not express the follicle stimulating hormone receptor (FSHR)
Conclusions:
We thus conclude that Her-2 can be a negative prognosticator only in FSHR negative EOC cases. Hence by stratifying EOC patients according to their FSHR expression status, we introduce a diagnostic protocol to effectively select EOC patients that would most probably respond to anti-Her-2 treatment. This observation could be of clinical importance in terms of selecting the patient that would most likely benefit from anti-Her-2 treatment. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 22, 2013 Category: Cancer & Oncology Authors: Sabine HeubleinThomas VrekoussisDoris MayrKlaus FrieseMiriam LenhardUdo JeschkeDarius Dian Source Type: research
Serum under-carboxylated osteocalcin levels in women with polycystic ovary syndrome: weight-dependent relationships with endocrine and metabolic traits
Conclusions:
Circulating ucOC concentration is related to key endocrine PCOS characteristics in a weight-dependent manner. Within the bone-pancreas loop, high ucOC may favor insulin release in lean hyperandrogenic women to compensate for impaired insulin sensitivity. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 22, 2013 Category: Cancer & Oncology Authors: Carmen Pepene Source Type: research
External validation of anti-Müllerian hormone based prediction of live birth in assisted conception
Conclusions:
We confirm by external validation that AMH and age are independent predictors of live birth. Although the confidence intervals for each category are wide, our results support the assessment of AMH in larger cohorts with detailed baseline phenotyping for live birth prediction. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 7, 2013 Category: Cancer & Oncology Authors: Amani KhaderSuzanne LloydAlex McConnachieRichard FlemingValentina GrisendiAntonio La MarcaScott Nelson Source Type: research
External validation of anti-Mullerian hormone based prediction of live birth in assisted conception
Conclusions:
We confirm by external validation that AMH and age are independent predictors of live birth. Although the confidence intervals for each category are wide, our results support the assessment of AMH in larger cohorts with detailed baseline phenotyping for live birth prediction. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 7, 2013 Category: Cancer & Oncology Authors: Amani KhaderSuzanne LloydAlex McConnachieRichard FlemingValentina GrisendiAntonio La MarcaScott Nelson Source Type: research
Molecular cytogenetics as a clinical test for
prognostic and predictive biomarkers in newly
diagnosed ovarian cancer
Conclusions:
Clinical genomic profiling of ovarian tumors by array CGH augments pathologic grade and stage to help stratify newly diagnosed ovarian cancer into high and low-risk disease. This personalized genomic information can also help guide treatment planning and disease monitoring by identifying novel potentially targetable genomic alterations that can be used by clinicians to choose rational directed therapies for patients with chemo-resistant disease. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 4, 2013 Category: Cancer & Oncology Authors: Shelly GunnXavier RevelesKorrie WeldonAndres BarreraMariam IshaqueDale TaylorChris McCaskillJaeweon KimRashmi ShahMansoor MohammedTodd BarryBrianne KaiserAmita PatnaikAnthony Tolcher Source Type: research
Pronuclear morphology evaluation in in vitro fertilization (IVF) / intracytoplasmic sperm injection (ICSI) cycles: a retrospective clinical review
Conclusions:
Pronuclear evaluation is effective to select the best zygotes if ET is performed at day 1, whereas it did not improve the clinical outcomes when combined with embryo morphology evaluation in day 2. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - January 3, 2013 Category: Cancer & Oncology Authors: Alessia NicoliFrancesco CapodannoIlaria RondiniBarbara ValliMaria VillaniDaria MoriniLeonardo De PascalisStefano PalombaGiovanni La Sala Source Type: research
