Ovarian adult stem cells: hope or pitfall?
For many years, ovarian biology has been based on the dogma that oocytes reserve in female mammals included a finite number, established before or at birth and it is determined by the number and quality of primordial follicles developed during the neonatal period. The restricted supply of oocytes in adult female mammals has been disputed in recent years by supporters of postnatal neo-oogenesis. Recent experimental data showed that ovarian surface epithelium and cortical tissue from both mouse and human were proved to contain very low proportion of cells able to propagate themselves, but also to generate immature oocytes in...
Source: Journal of Ovarian Research - July 4, 2014 Category: Cancer & Oncology Authors: Ancuta Augustina Gheorghisan-GalateanuMihail Eugen HinescuAna Maria Enciu Source Type: research
Outcomes of ovarian transposition in gynaecological cancers; a systematic review and meta-analysis
Conclusion:
Ovarian transposition is associated with significant preservation of ovarian function and negligible risk for metastases to the transposed ovaries despite common incidence of ovarian cysts. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 25, 2014 Category: Cancer & Oncology Authors: Kumar GubbalaAlex LaiosIoannis GallosPubudu PathirajaKrishnayan HaldarThomas Ind Source Type: research
Positive effects of prolonged caloric restriction on the population of very small embryonic-like stem cells - hematopoietic and ovarian implications
Conclusion:
We conclude that CR positively affects the pool of VSELs in adult tissues and explains the positive effect of CR on longevity. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 21, 2014 Category: Cancer & Oncology Authors: Katarzyna GrymulaKatarzyna PiotrowskaSylwia S¿uczanowska-G¿¿bowskaKatarzyna MierzejewskaMaciej TarnowskiMarta TkaczAgata Poniewierska-BaranDaniel P¿dziwiatrEwa Suszy¿skaMaria Laszczy¿skaMariusz Ratajczak Source Type: research
Association between intrafollicular concentration of benzene and outcome of controlled ovarian stimulation in IVF/ICSI cycles: a pilot study
Conclusion:
In conclusion, ovarian response to endogenous and exogenous gonadotrophins appeared to be influenced by intra-follicular benzene levels. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 18, 2014 Category: Cancer & Oncology Authors: Carlo AlviggiRossella GuadagniAlessandro ConfortiGiuseppe CoppolaSilvia PicarelliPasquale De RosaRoberta ValloneIda StrinaTiziana PaganoAntonio MolloAntonio AcamporaGiuseppe De Placido Source Type: research
Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age
Conclusions:
These results indicate that high proportions of human embryos from patients of advanced maternal age are aneuploid, and the arrested embryos are more likely to have abnormal chromosomes than developing embryos. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 13, 2014 Category: Cancer & Oncology Authors: Shu-Tao QiLi-Feng LiangYe-Xing XianJian-Qiao LiuWeihua Wang Source Type: research
New construction of an animal model for the orthotopic transplantation of an ovarian tumor
A new technique has successfully established the non-obese diabetic/severely combined immunodeficiency (NOD/SCID) mouse model of ovarian cancer. Under 4% chloral hydrate (0.1 mL/g dose) anesthesia, female mice were inoculated with tumor-cell suspension. The expression rate of OVCAR3 to CA125 was assessed using flow cytometry. The inoculated site was hand palpated and the signs and symptoms related to tumor growth were observed with the naked eye. The allophycocyanin (APC) indirectly labeled mouse-antihuman CA125 and fluorescein isothiocyanate (FITC)-labeled anti-mouse MHC Class I molecule (H-2Kd/H-2Dd) were observed using ...
Source: Journal of Ovarian Research - June 11, 2014 Category: Cancer & Oncology Authors: Hui ZhangXinping GaoYongan YangWeiming WangJin LiuYijuan LiangHongli WuJinjin QinKun PanYifeng WangJunrong ShiYouju Ma Source Type: research
Evaluation of the ovarian reserve function in patients with metabolic syndrome in relation to healthy controls and different age groups
Conclusion:
Ovarian reserve function is significantly lower in MetS patients than in healthy control subjects, particularly in women aged 20-29 years. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 10, 2014 Category: Cancer & Oncology Authors: Fevzi BalkanNurcan CetinCelil UsluogullariOguz UnalBetul Usluogullari Source Type: research
Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer
Conclusion:
Among the tested proteins the HE4 marker appears to be helpful in forecasting of optimal cytoreduction and possibly also of the prediction of response to platinum analogues used in first-line treatment of ovarian cancer. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 10, 2014 Category: Cancer & Oncology Authors: Anita Chudecka-G¿azAneta Cymbaluk-P¿oskaJanusz MenkiszakAgnieszka Sompolska-Rzechu¿aAleksandra To¿oczko-GrabarekIzabella Rzepka-Górska Source Type: research
Reliable in vitro studies require appropriate ovarian cancer cell lines
In this study we examined all ovarian cancer cell lines available from cell banks. Hereby, we identified inconsistencies in the reporting, difficulties in the identification of cell origin or clinical data of the donor patients, restricted ethnic and histological type representation, and a lack of tubal and peritoneal cancer cell lines. We recommend that all cell lines should be distributed via official cell banks only with strict guidelines regarding the minimal available information required to improve the quality of ovarian cancer research in future. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - June 7, 2014 Category: Cancer & Oncology Authors: Francis JacobSheri NixdorfNeville HackerViola Heinzelmann-Schwarz Source Type: research
Laparoscopic fertility-sparing surgery for early stage ovarian cancer: a single-centre case series and systematic literature review
Conclusions:
Laparoscopic staging may represent a viable option for premenopausal women seeking fertility preservation in the setting of early ovarian cancer. More research is needed to determine whether laparoscopy may offer reproductive benefits to this particular population. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 29, 2014 Category: Cancer & Oncology Authors: Antonella CromiGiorgio BoganiStefano UccellaJvan CasarinMaurizio SeratiFabio Ghezzi Source Type: research
Plasma concentrations of D-dimer and outcome of in vitro fertilization
Conclusions:
D-dimer concentrations seem to predict a higher risk of pregnancy failure in women undergoing IVF. If confirmed in future prospective studies, D-dimer could help identifying a group of patients who could benefit from prophylaxis to increase the pregnancy success rate. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 22, 2014 Category: Cancer & Oncology Authors: Marcello Di NisioEttore PorrecaValeria Di DonatoGian Mario Tiboni Source Type: research
Bevacizumab in combination with chemotherapy for the treatment of advanced ovarian cancer: a systematic review
As increased angiogenesis has been linked with the progression of ovarian cancer, a number of anti-angiogenic agents have been investigated, or are currently in development, as potential treatment options for patients with advanced disease. Bevacizumab, a recombinant monoclonal antibody against vascular endothelial growth factor, has gained European Medicines Agency approval for the front-line treatment of advanced epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer in combination with carboplatin and paclitaxel, and for the treatment of first recurrence of platinum-sensitive ovarian cancer in com...
Source: Journal of Ovarian Research - May 19, 2014 Category: Cancer & Oncology Authors: Gerasimos AravantinosDimitrios Pectasides Source Type: research
¿Platelet-associated regulatory system (PARS)¿ with particular reference to female reproduction
Conclusion:
Based on clinical and experimental evidences we propose that platelets modulate the function of hypothalamo-hypophyseal-ovarian system. Specifically, hypothalamic GnRH releases FSH from the anterior pituitary, which induces and stimulates follicular and oocyte maturation and steroid hormone secretion in the ovary. At the same time follicular cells enhance PAF production. Through these pathways activated platelets are accumulated in the follicular vessels surrounding the follicle and due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters) locally increase oocyte matur...
Source: Journal of Ovarian Research - May 16, 2014 Category: Cancer & Oncology Authors: József BódisSzilárd PappIstván VermesEndre SulyokPéter TamásBálint FarkasKatalin ZámbóIoannis HatzipetrosGábor Kovács Source Type: research
Polymorphisms of VEGF and VEGF receptors are associated with the occurrence of ovarian hyperstimulation syndrome (OHSS)--a retrospective case-control study
Conclusion:
Polymorphisms in the VEGFR2 gene and in the VEGF gene are associated with the occurrence of OHSS. This strengthens the evidence for an important role of the VEGF/VEGF- receptor system in the occurrence of OHSS. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 13, 2014 Category: Cancer & Oncology Authors: Kazem NouriPeter HaslingerLadislaus SzaboMichael SatorMartin SchreiberChristian SchneebergerDetlef Pietrowski Source Type: research
KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries
Conclusions:
Ovarian cancers display amplified centrosomes, a feature of aggressive tumors. To cope up with the abnormal centrosomal load, ovarian cancer cells upregulate genes like KIFC1 that are known to induce centrosome clustering. Our data underscore KIFC1 as a putative biomarker that predicts worse prognosis, poor overall survival and may serve as a potential marker of onset of metastatic dissemination in ovarian cancer patients. (Source: Journal of Ovarian Research)
Source: Journal of Ovarian Research - May 12, 2014 Category: Cancer & Oncology Authors: Shrikant PawarShashikiran DonthamsettyVaishali PannuPadmashree RidaAngela OgdenNathan BowenRemus OsanGuilherme CantuariaRitu Aneja Source Type: research
