Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models
Conclusions:
The results suggest that the prevention of CTR1 degradation by bortezomib may be playing a major role in increasing the cellular uptake of platinum drugs and platinum-DNA binding level. Furthermore, the generation of oxidative stress appears to be a major contributor to the enhanced cell kill.
Source: Journal of Ovarian Research - Category: Cancer & Oncology Authors: Zaynab Al-EisawiPhilip BealeCharles ChanJun YuFazlul Huq Source Type: research
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