Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour models

Conclusions: The results suggest that the prevention of CTR1 degradation by bortezomib may be playing a major role in increasing the cellular uptake of platinum drugs and platinum-DNA binding level. Furthermore, the generation of oxidative stress appears to be a major contributor to the enhanced cell kill.
Source: Journal of Ovarian Research - Category: Cancer & Oncology Authors: Source Type: research