Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse
Conclusion:
We conclude that hyperandrogenization (PCOS) by DHEA diminishes ovarian Rac1 and Vav expression and activity along with an increase in expression of Caveolin1. Further, the levels of intra-ovarian 17beta-estradiol and inhibin B were also found to be elevated in the polycystic ovary.
Source: Journal of Ovarian Research - Category: Cancer & Oncology Authors: Vineet MauryaSangappa ChadchanVijay KumarSahil MahfoozArchana SinghSingh RajenderRajesh Jha Source Type: research
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