Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse

Conclusion: We conclude that hyperandrogenization (PCOS) by DHEA diminishes ovarian Rac1 and Vav expression and activity along with an increase in expression of Caveolin1. Further, the levels of intra-ovarian 17beta-estradiol and inhibin B were also found to be elevated in the polycystic ovary.
Source: Journal of Ovarian Research - Category: Cancer & Oncology Authors: Source Type: research