Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

Conclusions: This work thus opens new perspectives for the use of this promising molecule for the treatment of highly chemoresistant ovarian cancer cells and for sensitization of emerging Bcl-xL targeting strategies such as the use of BH3-mimetic molecules.

http://www.ovarianresearch.com/content/6/1/38

Source: Journal of Ovarian Research - June 5, 2013 Category: Cancer & Oncology Authors: Julie TomasinaAurélie Malzert-FreonFlorence GiffardEmilie BrotinMarie-Hélène LouisEdwige AbeilardSylvain RaultPascal GauduchonLaurent Poulain Source Type: research