Journal of Equine Veterinary Science This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Upregulation of Inflammatory Cytokines Is Associated with Alteration in Prostaglandin Pathways and Sex-steroid Receptors in the Cervix of Mares with Placentitis
Changes in the cervical barrier in the pregnant mare are an integral part of the pathogenesis of abortion associated with ascending placentitis. However, there is little information regarding changes in the equine cervix associated with this infection. To better characterize molecular changes in the cervix during placentitis, we examined mRNA expression for a number of inflammatory and endocrine factors in the mucosa and stroma of the cervix of mares (n=5) after experimental induction of placentitis via transcervical inoculation with Streptococcus. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: C.B. Fernandes, A. Esteller-Vico, S.C. Loux, K.E. Scoggin, Y.L. Boakari, E.L. Squires, M.H. Troedsson, B.A. Ball Source Type: research

Inflammatory Mediator Production in Fetal Fluids after Firocoxib Treatment in Mares with Experimentally-induced Placentitis
The goal of this study was to characterize anti-inflammatory effects of firocoxib in fetal fluids obtained from mares with placentitis. Placentitis was induced in 18 pregnant mares by direct chorioallantoic deposition of S.equi spp. zooepidemicus (gestational day 270 to 300). Mares were randomly assigned to: Group INFECT (n=6; experimental induction of placentitis, no treatment), Group FIRO (n=6; experimental induction of placentitis, administration of firocoxib); and Group NORM (n=6; normal foaling mares, no infection or treatment). (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: M.L. Macpherson, S. Gigu ère, M.A. Pozor, C.A. Burden, J.T. Hayna, L. Berghaus, S. Randell, S.A. Benson, S.K. Lyle, A.A. Kelleman, M.M. Mallicote Source Type: research

Equine Placentitis Is Associated with a Downregulation in Myometrial Progesterone Signaling
A key event in preterm labor due to placentitis is the loss of myometrial quiescence and the initiation of labor. It is well known that progesterone (P4) acting through its nuclear receptor (PR) maintains uterine quiescence in most species through a blockade of the inflammatory cascade and suppression of uterine contraction. Therefore, P4 withdrawal or functional withdrawal (alteration in PR) have been implicated in labor and preterm labor. The current study aimed to elucidate the mechanisms underlying myometrial activation during equine placentitis related to P4-PR signaling pathways. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: H. El-Sheikh Ali, E. Legacki, S.C. Loux, A. Esteller-Vico, K.E. Scoggin, A.J. Conley, S.D. Stanley, B.A. Ball Source Type: research

Effects of Acute Stress on Parturition in Pony Mares
In this study, we followed the hypothesis that parasympathetic dominance during expulsion of the foal can be overridden by an acute stress response during labor. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: C. Aurich, M. Melchert, C. Gauthier, J. Aurich, C. Nagel Source Type: research

Incidence and Pathology of Abortions Associated with Umbilical Cord Torsions
The objectives of this study were to (i) determine the proportion of pregnancy losses attributed to UC pathologies in a Newmarket thoroughbred subpopulation and (ii) describe and compare the characteristics and gross pathological lesions in UC-related and non-UC-related abortions. A retrospective cohort study collected pregnancy outcomes on 2,245 pregnancies from 29 studs for the 2013 and 2014 breeding seasons. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: J.M. Roach, K.L.P. Verheyen, K.C. Smith, M. Molyneux, J. Bryan, A. Foote, A.M. de Mestre Source Type: research

Transcriptomic Analysis of the Chorioallantois from Mares with Nocardioform Placentitis
Nocardioform placentitis (NP) continues to result in episodic outbreaks of abortion in mares. NP is characterized as a mucoid placentitis in which the bacterial infection is limited to the chorionic surface of the placenta without infection of the fetus. To date, the pathogenesis of the infection remains unknown and attempts to induce the infection in pregnant mares have been unsuccessful. Likewise, the ecology and biology of the major causative organisms, Crossiella equi and Amycolatopsis sp. remains unknown. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: B.A. Ball, S.C. Loux, L. Kennedy, T.S. Kalbfleisch, K.E. Scoggin, A. Esteller-Vico, D.W. Horohov, E. Erol, C.N. Carter, J.L. Smith Source Type: research

Enrofloxacin and Its Active Metabolite Ciprofloxacin Cross the Equine Placenta and Did not Cause Lesions in the Articular Surface of the Fetuses and Foals
The objectives of this study were to determine: (i) concentrations of enrofloxacin and ciprofloxacin in plasma (maternal and fetal) and fetal fluids of mares treated with enrofloxacin in late-term pregnancy, (ii) if in utero exposure to enrofloxacin and ciprofloxacin resulted in macroscopic or microscopic lesions in fetal membranes or tissues (liver, kidney, placenta, or articular cartilage), and (iii) if in utero exposure to enrofloxacin and ciprofloxacin resulted in clinical lameness, or lesions in articular cartilage or tendons of the resulting foals. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: R.E. Ellerbrock, I.F. Canisso, P.J. Roady, B. Curcio, F.S. Lima, Z. Li Source Type: research

Effect of Acetylsalicylic Acid on Uterine Blood Flow and Feto-Placental Development in Pregnant Mares
Colour Doppler sonography illustrates a rise in uterine blood flow during pregnancy in mares. Acetylsalicylic acid (ASA) inhibits platelet aggregation and is used to increase uterine blood flow in women. First studies indicated an increase in uterine perfusion in cyclic mares (Bollwein et al. Theriogenology 61 (2004) 301 –309). The aim of the present study was to analyze the effect of ASA on uterine blood flow, placental development and foal birth weight in mares with previously physiological (n=12) and disturbed pregnancies (n=4). (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: J. Sielhorst, U. B ücker, A. Kahler, K. Rohn, R. Koch, C. Pfarrer, H. Bollwein, H. Sieme Source Type: research

Profiling of Aneuploidies and Structural Genomic Variants in Placentae from Mares that Suffer Early Pregnancy Loss
The objective of this study was to determine the numerical chromosomal content and copy number variation (CNV) profile of EPL placentae and compare identified CNV regions (CNVR) in healthy and failed early pregnancies. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: H. Smart, B.V. Rose, G. Baldwin, D. Hampshire, K.L.P. Verheyen, D.C. Wathes, S. Ghosh, T. Raudsepp, A.M. de Mestre Source Type: research

Sonographic Appearance of the Late Gestation Equine Fetal Intestine
Variable gestation length in the mare poses a challenge for determination of fetal readiness for birth. Normal parameters to assess equine fetal well-being have been established (Reef.et.al. EVJ. 1996; 28:3:200-208), though few of those parameters accurately determine fetal maturity. In canids and humans, fetal GI tract ultrasonographic character can predict fetal maturity (Zilanti.et.al. Obstetrics Gynecology. 1983; 62:569-573, Goldstein.et.al. Obstetrics Gynecology. 1987; 70:5:682-686, Gil.et.al. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: M.E. Agnew, J.A. Slack, D. Stefanovski, J.K. Linton, P.L. Sertich Source Type: research

Influence of Parity on Oxidative Status in Pregnant, Peripartum and Postpartum Mares
Several studies on oxidative status during pregnancy and in the postpartum period are found in women, as is it well recognized that oxidative stress plays an important role in diseases. In mares, few studies evaluating oxidative profile during this period are found. It is well established that several metabolic alterations take place during pregnancy, characterized by high metabolic and energetic demand, especially of oxygen which could increase the production of reactive species and predispose the organism to oxidative stress. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: M.A. Alonso, D.F. Souza, A.V. Riccio, F.J. Affonso, M.M. Brito, M.C.P. Francischini, F.C. Neves, G.K.V. Kawai, M. Nichi, C.B. Fernandes Source Type: research

Alterations of the CTUP in Response to Ascending Placentitis Precede Changes in Hematologic Inflammatory Markers and Changes in Allantoic Metabolites
Ascending placentitis is one of the leading infectious causes of equine fetal demise, contributing to approximately 30% of all pregnancy loss in the United States and France (Giles et al. JAVMA. 1993;203:1170-1175 and Laguier et al. J Equine Vet Sci. 2011;31:116-123). Diagnosis of placentits is complicated by minimal premonitory signs or consistent hematologic alterations (Macpherson et. al. Vet Clin Equine. 2006;22:763-776). Metabolomics, utilizing nuclear magnetic resonance (NMR) spectroscopy, can identify and quantify all products of metabolism and may allow for characterization of different pathologic states, including...
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: T.M. Beachler, H.S. Gracz, D.R. Morgan, K.A. Von Dollen, K.E. Ellis, S.K. Lyle, SA Bembenek Bailey, A.M. Nebel, N.C. Andrews, J. Koipillai, S. Frable, C.S. Bailey Source Type: research

Serum Concentration and mRNA Expression of Serum Amyloid A and Serum Amyloid A1 in Pregnant Mares and Their Fetuses after Experimental Induction of Placentitis
The objectives of this study were to evaluate maternal and fetal systemic concentration of SAA and mRNA expression of SAA and SAA1 in maternal liver, fetal liver, endometrium and chorioallantois in 5 pregnant mares with experimental placentitis and 4 matching controls. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: Y.L. Boakari, S.C. Loux, C.B. Fernandes, K.E. Scoggin, C. Facison, C. Cray, B.A. Ball, A. Esteller-Vico Source Type: research

Equine Embryo and Early Fetus Development in Recipient Mules and Mares
In countries such as Brazil and Argentina where the equine embryo transfer technique has become widespread, shortages in recipient mares are a real problem. Therefore, one alternative might be to use mules as recipients for equine embryos. The aim of this study was to compare the embryonic and early fetal development of horse embryos between recipient mules and mares from day 10 to 60 of pregnancy. Embryo donor mares (n=5) and two groups of recipients (acyclic mules, n=7; cyclic mares, n=10) were used. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: C.E. Camargo, S.M. Fiala Rechsteiner, M.O. Gastal, E.L. Gastal Source Type: research

Peripheral Markers Profiles in Response to Treatment for Experimental Placentitis in Mares
This study aimed to describe the plasma concentrations of estradiol-17 β, progesterone, alpha-fetoprotein (AFP), and serum amyloid A (SAA) in response to treatment for placentitis. Eighteen pony mares carrying normal pregnancies 270-295d gestation were enrolled in the study for two foaling seasons. Experiment I, mares were randomly assigned to one of three groups: INF ECT (n=6; experimental induction of placentitis, no treatment); FIRO (n=6; experimental induction of placentitis and treatment with firocoxib 0.3 mg/kg for 24h and then maintained with 0.1 mg/kg until delivery, with onset of administration beginning 3 days b...
Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: I.F. Canisso, B.R. Curcio, C. Burden, J. Hayna, S.M. Benson, S.R. Randell, S. Giguere, M. Pozor, M.L. Macpherson Source Type: research