Inflammatory Mediator Production in Fetal Fluids after Firocoxib Treatment in Mares with Experimentally-induced Placentitis

The goal of this study was to characterize anti-inflammatory effects of firocoxib in fetal fluids obtained from mares with placentitis. Placentitis was induced in 18 pregnant mares by direct chorioallantoic deposition of S.equi spp. zooepidemicus (gestational day 270 to 300). Mares were randomly assigned to: Group INFECT (n=6; experimental induction of placentitis, no treatment), Group FIRO (n=6; experimental induction of placentitis, administration of firocoxib); and Group NORM (n=6; normal foaling mares, no infection or treatment).

Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: M.L. Macpherson, S. Gigu ère, M.A. Pozor, C.A. Burden, J.T. Hayna, L. Berghaus, S. Randell, S.A. Benson, S.K. Lyle, A.A. Kelleman, M.M. Mallicote Source Type: research