Upregulation of Inflammatory Cytokines Is Associated with Alteration in Prostaglandin Pathways and Sex-steroid Receptors in the Cervix of Mares with Placentitis

Changes in the cervical barrier in the pregnant mare are an integral part of the pathogenesis of abortion associated with ascending placentitis. However, there is little information regarding changes in the equine cervix associated with this infection. To better characterize molecular changes in the cervix during placentitis, we examined mRNA expression for a number of inflammatory and endocrine factors in the mucosa and stroma of the cervix of mares (n=5) after experimental induction of placentitis via transcervical inoculation with Streptococcus.

Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: C.B. Fernandes, A. Esteller-Vico, S.C. Loux, K.E. Scoggin, Y.L. Boakari, E.L. Squires, M.H. Troedsson, B.A. Ball Source Type: research