Antibacterial activity of green silver nanoparticles synthesized from Anogeissus acuminata against multidrug resistant urinary tract infecting bacteria in vitro and host-toxicity testing
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): Monali P. Mishra, Rabindra N. PadhyAbstractSilver nanoparticles (AgNPs) with aqueous leaf-extract of the timber-yielding plant Anogeissus acuminata were synthesized for in vitro control of pathogenic bacteria. Characterization of AgNPs with ultraviolet-visible spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, X-Ray diffraction (XRD) study and Fourier transformed infrared spectroscopy (FTIR) study was done for a confirmation of the synthesis. The SEM analysis confirmed that the metal par...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): Yan Li, Wenting Zhang, Chun Chen, Chunping Zhang, Jingyu Duan, Huankai Yao, Qunli Wei, Aiguo Meng, Jun ShiAbstractIschemic stroke is a severe cause of disability and death all over the world. To search for effective therapy for ischemic stroke, PC12 cells damaged by oxygenation and glucose deprivation/restoration were employed to assess the protective effects of inotodiol. As a result, inotodiol can improve the cell viability and attenuate the leakage of lactate dehydrogenase. Meanwhile, inotodiol can prevent oxidative stress by ...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Caveolin-1 rs4730751 gene polymorphism in kidney allograft recipients
This study enrolled 270 Caucasian deceased – donor renal transplant recipients. We found no statistically significant associations between CAV1 rs4730751 and delayed graft function, acute rejection, or chronic allograft dysfunction, as well as creatinine values at 1–60 months after transplantation, the risk of graft loss, dialysis or death after transplantation, or histopathological changes in kidney allograft biopsies. Our findings do not support an association between the CAV1 gene rs4730751 polymorphism and kidney allograft function in our population.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Nonlinear Heart Rate Variability based artificial intelligence in lung cancer prediction
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): Reema Shyamsunder Shukla, Yogender AggarwalAbstractLung cancer is uncontrolled growth of cells that occurs due to exposure to smoke, radiation and chemicals, which causes chronic stress and associated with impaired autonomic nervous system. Nonlinear heart rate variability (HRV) analysis has been suggested to uncover the performance status of lung cancer subjects and distinguish them from healthy controls. The present work obtained tachogram from recorded electrocardiogram of 104 lung cancer subjects and 30 healthy controls to ex...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Legislation, regulation and policies issues of orphan drugs in developed countries from 2010 to 2016
Publication date: Available online 1 May 2018Source: Journal of Applied BiomedicineAuthor(s): Petra Maresova, Blanka Klimova, Kamil KucaAbstractThe purpose of this study is to evaluate current legislative policies and regulations with respect to the use of orphan drugs, to emphasize strengths and weaknesses of these policies in the period of 2010–2016 in European countries, especially in relation to the objectives set by the European Council in 2009. This was done by the method of literature search in the databases PubMed, Scopus, ScienceDirect, and Web of Science from 2010 to 2016. The findings show a lack of polices fo...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Contents
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Propolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): Ummay Mahfuza Shapla, Jinat Raihan, Asiful Islam, Fahmida Alam, Naeem Solayman, Siew Hua Gan, Sakib Hossen, Ibrahim KhalilAbstractHelicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very ef...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
In vitro antimalarial activity of synthesized TiO2 nanoparticles using Momordica charantia leaf extract against Plasmodium falciparum
Publication date: Available online 8 May 2018Source: Journal of Applied BiomedicineAuthor(s): Pachiyappan Rajiv Gandhi, Chidambaram Jayaseelan, Chinnaperumal Kamaraj, S.R. Radhika Rajasree, Rathinasamy Regina MaryAbstractMalaria is a serious global health challenge, and it has infected millions of people worldwide. There is an urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy. In the present study, we biosynthesized TiO2 nanoparticles (NPs) using the Momordica charantia leaf aqueous extract as a reducing and stabilizing agent. TiO2 NPs were characterized by UV, XRD, FTIR, HRTEM, ...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Effect of different loads of treadmill exercise on Th1/Th2 cytokine balance in rat splenocytes
Publication date: Available online 24 May 2018Source: Journal of Applied BiomedicineAuthor(s): Zahra Gholamnezhad, Mohammad Hossein Boskabady, Mahmoud HosseiniAbstractThe effect of moderate and overtraining exercise on Th1/Th2 balance was evaluated in rat splenocytes. Male Wistar rats were divided into sedentary control (C), moderately trained (MT; V = 20 m/min, 30 min/day, 8 weeks), overtrained (OT; V = 25 m/min, 60 min/day, 11 weeks) and recovered after overtraining (OR) (OT plus 2 weeks recovery) groups. At the end of study, cell viability, proliferation, interleukin 4 (IL-4) and interferon-γ (IFN-γ) s...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
A proteomic glimpse into the oncogenesis of prostate cancer
Publication date: Available online 24 May 2018Source: Journal of Applied BiomedicineAuthor(s): Patrícia Borba Martiny, Diego Duarte Alcoba, Brasil Silva Neto, Paulo Costa Carvalho, Ilma Simoni BrumAbstractProstate cancer (PCa) is the second most frequent cancer in men worldwide. Distinguishing between the nonaggressive and aggressive forms of this disease is difficult, and a means to better characterize molecular patterns that could aid in diagnosis is urgently needed. Here, we compare the proteomic profiles of PCa and benign prostatic hyperplasia (BPH) in an effort to elucidate underlying mechanisms of oncogenesis. We co...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
This study aimed to ascertain antidiabetic potential of methanolic extract of Pseuduvaria macrophylla bark (PM) using streptozotocin-nicotinamide induced diabetic rat models. Various phytochemical and biochemical properties of the plant have been evaluated. The results showed that the extract has potentially normalized the elevated blood glucose levels by upregulating the insulin and C-peptide levels and alleviated oxidative stress by improving glutathione (GSH) and reducing lipid peroxidation (LPO) in the diabetic rats. In addition, PM has drastically downregulated the levels of pro-inflammatory cytokines and transforming...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways
ConclusionRAG may have clinical utility to decrease the dosage of 5-FU in colorectal cancer therapeutics.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Adipocytokines and new onset diabetes mellitus after transplantation
Publication date: Available online 31 May 2018Source: Journal of Applied BiomedicineAuthor(s): Dominika Goldmannová, Jaromíra Spurná, Ondřej Krystyník, Jan Schovánek, Lubica Cibičková, David Karásek, Josef ZadražilAbstractBackground and aimDiabetes mellitus is a very common metabolic disease with a rising incidence. It is one of the most serious comorbidities in renal transplant recipients. New-onset diabetes after renal transplantation (NODAT) is associated with poor graft function, higher rates of cardiovascular complications and a poor prognosis. Adipocytokines, synthetized by adipose tissue influence metaboli...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Berbamine protects the heart from isoproterenol induced myocardial infarction by modulating eNOS and iNOS expressions in rats
Publication date: Available online 7 June 2018Source: Journal of Applied BiomedicineAuthor(s): Saranya Sithuraj, Vijaya Padma ViswanadhaAbstractAimThe current study was designed to investigate the effect of berbamine (BBM) on isoproterenol (ISO) induced changes in cardiac marker enzymes, myocardial oxidative stress, lipid profile and expression of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in male Wistar rats. Rats were pretreated with BBM (25 mg/kg) through intraperitoneal injection for 7 days followed by induction of myocardial infarction (MI) by subcutaneous injection of ISO (8...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Berbamine protects the heart from isoproterenol induced myocardial infarction by modulating eNOS and iNOS expressions in rats
Publication date: Available online 7 June 2018 Source:Journal of Applied Biomedicine Author(s): Saranya Sithuraj, Vijaya Padma Viswanadha Aim The current study was designed to investigate the effect of berbamine (BBM) on isoproterenol (ISO) induced changes in cardiac marker enzymes, myocardial oxidative stress, lipid profile and expression of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in male Wistar rats. Rats were pretreated with BBM (25 mg/kg) through intraperitoneal injection for 7 days followed by induction of myocardial infarction (MI) by subcutaneous injection of ISO (85...
Source: Journal of Applied Biomedicine - June 7, 2018 Category: Biotechnology Source Type: research
