Causal link of total locomotor activity, melatonin and rectal temperature daily rhythm in small ruminants
In conclusion, in small ruminants, melatonin and rectal temperature daily rhythms are strictly correlated, and are not associated with the locomotor activity rhythm. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - February 8, 2016 Category: Biotechnology Source Type: research
Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria
Publication date: Available online 8 February 2016 Source:Journal of Applied Biomedicine Author(s): Ivan Kushkevych, Peter Kollar, Ana Luisa Ferreira, Diogo Palma, Aida Duarte, Maria Manuel Lopes, Milan Bartos, Karel Pauk, Ales Imramovsky, Josef Jampilek Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (IBD); unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives against two different genera of intestinal SRB, Des...
Source: Journal of Applied Biomedicine - February 8, 2016 Category: Biotechnology Source Type: research
Development of biocompatible nanogel for sustained drug release by overcoming the blood brain barrier in zebrafish model
This study may shed light on the development of neurospecific nanogel for targeted and sustained drug release to brain by crossing the blood–brain barrier. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - February 6, 2016 Category: Biotechnology Source Type: research
Phenazine-1-carboxylic acid-induced programmed cell death in human prostate cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway
Publication date: Available online 23 January 2016 Source:Journal of Applied Biomedicine Author(s): Valliappan Karuppiah, Kumarappan Alagappan, Kannan Sivakumar, Lakshmanan Kannan Phenazine-1-carboxylic acid has extensive pharmacological activity, including antibiotic and immunomodulatory, but the anticancer activity remains unknown. Treatment of prostate cancer cell line (DU145) with phenazine-1-carboxylic acid stimulated inhibition of cell proliferation in concentration- and time-dependent manner. Dual staining confirmed phenazine-1-carboxylic acid stimulated prostate cancer programmed cell death in time-depe...
Source: Journal of Applied Biomedicine - February 5, 2016 Category: Biotechnology Source Type: research
Phenazine-1-carboxylic acid-induced apoptosis in human prostate cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway
Publication date: Available online 23 January 2016 Source:Journal of Applied Biomedicine Author(s): Valliappan Karuppiah, Kumarappan Alagappan, Kannan Sivakumar, Lakshmanan Kannan Phenazine-1-carboxylic acid has extensive pharmacological activity, including antibiotic and immunomodulatory, but the anticancer activity remains unknown. Treatment of prostate cancer cell line (DU145) with phenazine-1-carboxylic acid stimulated inhibition of cell proliferation in concentration- and time-dependent manner. Dual staining confirmed phenazine-1-carboxylic acid stimulated prostate cancer cell apoptosis in time-dependent m...
Source: Journal of Applied Biomedicine - January 24, 2016 Category: Biotechnology Source Type: research
Carbamates pesticides induced immunotoxicity and carcinogenicity in human: A review
Publication date: Available online 15 January 2016 Source:Journal of Applied Biomedicine Author(s): Ines Dhouib, Alya Annabi, Manel Jallouli, Soumaya Marzouki, Najoua Gharbi, Saloua Elfazaa, Mohamed Montassar Lasram In the literature, carbamates pesticides (CMs) have been implicated in the increasing prevalence of diseases associated with alterations of the immune response, such as hypersensitivity reactions, some autoimmune diseases and cancers. CMs may initiate, facilitate or exacerbate pathological immune processes, resulting in immunotoxicity by induction of mutations in genes coding for immunoregulat...
Source: Journal of Applied Biomedicine - January 16, 2016 Category: Biotechnology Source Type: research
DDE downregulates PLIN2 expression during differentiation of mesenchymal stem cells into adipocytes in lipid-enriched medium
Publication date: Available online 15 January 2016 Source:Journal of Applied Biomedicine Author(s): Dana Müllerová, Martin Pešta, Miroslava Čedíková, Jana Dvořáková, Vlastimil Kulda, Kristýna Srbecká, Luděk Müller, Pavel Dvořák, Michaela Kripnerová, Milena Králíčková, Václav Babuška, Jitka Kuncová Evidence indicating, that persistent organic pollutants are involved in the development of obesity, has emerged. The aim of this study was to reveal whether an environmental bioaccumulative human adipose tissue contaminant, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), affe...
Source: Journal of Applied Biomedicine - January 16, 2016 Category: Biotechnology Source Type: research
Reviewers Acknowledgements
Publication date: February 2016 Source:Journal of Applied Biomedicine, Volume 14, Issue 1 (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - January 11, 2016 Category: Biotechnology Source Type: research
Biotherapies of rabbit serum modulate the immune response and decrease parasite load in mice infected with Trypanosoma cruzi
This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-...
Source: Journal of Applied Biomedicine - December 2, 2015 Category: Biotechnology Source Type: research
Extracorporeal apheresis system – A nanoparticle drugs’ elimination method to enhance the benefit of cytostatic therapy in cancer patients
Publication date: Available online 22 November 2015 Source:Journal of Applied Biomedicine Author(s): Stanislav Filip, Ondřej Kubeček, Jiří Špaček, Jiřina Martínková, Milan Bláha Cytostatic treatment is often negatively affected by dose-limited toxicities. Novel agents, including nanoparticle-based drug delivery systems (DDS), are becoming available to overcome this problem. Despite achieving a lesser toxicity in exchange for more favorable pharmacokinetic profiles, the use of DDS is often associated with a particular toxicity profile. The accumulation of DDS in tumor tissue is much faster than in no...
Source: Journal of Applied Biomedicine - November 22, 2015 Category: Biotechnology Source Type: research
Quasi emulsion spherical crystallization technique based environmentally responsive Tulsion® (pH dependent) microspheres for colon specific delivery
Publication date: Available online 17 November 2015 Source:Journal of Applied Biomedicine Author(s): Ashish Jain, Ankit Jain, Abhishek Jain, Anki Jain pH-dependent sustained-release Tulsion® microspheres bearing clarithromycin were prepared using quasi-emulsion solvent diffusion method with thermocoat L 30 D 55 as a release retardant. Both, clarithromycin and thermocoat L 30 D 55, were found to be non-hemolytic during in vitro toxicity assay against human red blood cells. Ratiometric optimization of different solvents using phase diagrams was performed on amount of good solvent, bridging liquid, dispersing liq...
Source: Journal of Applied Biomedicine - November 20, 2015 Category: Biotechnology Source Type: research
Enhanced hypoxic tolerance by Seabuckthorn is due to upregulation of HIF-1α and attenuation of ER stress
Publication date: Available online 17 October 2015 Source:Journal of Applied Biomedicine Author(s): Kanika Jain, Geetha Suryakumar, Rajendra Prasad, Lilly Ganju, Shashi Bala Singh An imbalance in the redox homeostasis causes activation of multifaceted signaling responses which may be protective or deleterious. Amelioration of oxidative stress is one of the major modes of action of herbal supplements like Seabuckthorn (SBT). While the antioxidant potential of SBT is known, investigations into its effect on stress inducible signaling cascades are in progress. Here, we examine the impact of SBT on hypoxic tolera...
Source: Journal of Applied Biomedicine - November 7, 2015 Category: Biotechnology Source Type: research
Overt hypothyroidism is associated with blood inflammatory biomarkers dependent of lipid profile
Publication date: Available online 21 October 2015 Source:Journal of Applied Biomedicine Author(s): Adriana Santi, Ivana Beatrice Mânica da Cruz, Vania Lucia Loro, Marta Maria Medeiros Frescura Duarte, Fernanda Barbisan, Thiago Duarte, Anahy Gabriela Pasa To investigate the association between inflammatory biomarkers and overt hypothyroidism (OH). We measured inflammatory cytokines, interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) as well as cell-free DNA (cf-DNA) levels in 40 OH patients and 40 healthy controls. Total cholesterol, high and low dens...
Source: Journal of Applied Biomedicine - November 7, 2015 Category: Biotechnology Source Type: research
The relationship between amniotic epithelial cells and their microenvironment
Publication date: Available online 24 October 2015 Source:Journal of Applied Biomedicine Author(s): Katarzyna Kopaczka, Katarzyna Skowron, Emanuel Kolanko, Piotr Czekaj Human amniotic epithelial cells (hAEC) are characterized by a great ability to differentiate, and immunomodulatory properties toward mother's immune system cells. These features have been described as being able to change during pregnancy. Thanks to their unique properties: low immunogenicity and high effectiveness of transplantations, amniotic epithelial cells constitute a very attractive source of stem cells for practical purposes in regenerat...
Source: Journal of Applied Biomedicine - November 7, 2015 Category: Biotechnology Source Type: research
Protective effect of catechin rich extract of Rhizophora mucronata against β-amyloid-induced toxicity in PC12 cells
Publication date: Available online 30 October 2015 Source:Journal of Applied Biomedicine Author(s): Natarajan Suganthy, Kasi Pandima Devi Alzheimer's disease (AD) threatens to become the scourge of the 21st century, hence there is an urgent need for the exploration of multipotent drug in the treatment of AD. Rhizophora mucronata, tropical red mangrove has been widely used in traditional oriental medicine as astringent, antiseptic, antibacterial, anti-ulcerogenic and anti-inflammatory agent. The present study aimed to evaluate the neuroprotective effect of the catechin rich methanolic leaf extract of R. mucronata (M...
Source: Journal of Applied Biomedicine - November 7, 2015 Category: Biotechnology Source Type: research
