Legislation, regulation and policies issues of orphan drugs in developed countries from 2010 to 2016
Publication date: Available online 1 May 2018Source: Journal of Applied BiomedicineAuthor(s): Petra Maresova, Blanka Klimova, Kamil KucaAbstractThe purpose of this study is to evaluate current legislative policies and regulations with respect to the use of orphan drugs, to emphasize strengths and weaknesses of these policies in the period of 2010–2016 in European countries, especially in relation to the objectives set by the European Council in 2009. This was done by the method of literature search in the databases PubMed, Scopus, ScienceDirect, and Web of Science from 2010 to 2016. The findings show a lack of polices fo...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Contents
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Propolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases
Publication date: May 2018Source: Journal of Applied Biomedicine, Volume 16, Issue 2Author(s): Ummay Mahfuza Shapla, Jinat Raihan, Asiful Islam, Fahmida Alam, Naeem Solayman, Siew Hua Gan, Sakib Hossen, Ibrahim KhalilAbstractHelicobacter pylori (H. pylori), which is found in the stomach of approximately 50% of humans, remains there for almost the entire lifetime of the infected individual, leading to various gastrointestinal tract-associated disorders following full-blown infection. Due to the emergence of antibiotic resistance, recurrence and high cost of therapy, most antibiotic-based treatment strategies are not very ef...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
In vitro antimalarial activity of synthesized TiO2 nanoparticles using Momordica charantia leaf extract against Plasmodium falciparum
Publication date: Available online 8 May 2018Source: Journal of Applied BiomedicineAuthor(s): Pachiyappan Rajiv Gandhi, Chidambaram Jayaseelan, Chinnaperumal Kamaraj, S.R. Radhika Rajasree, Rathinasamy Regina MaryAbstractMalaria is a serious global health challenge, and it has infected millions of people worldwide. There is an urgent need for new antimalarial drugs and drug targets for both prophylaxis and chemotherapy. In the present study, we biosynthesized TiO2 nanoparticles (NPs) using the Momordica charantia leaf aqueous extract as a reducing and stabilizing agent. TiO2 NPs were characterized by UV, XRD, FTIR, HRTEM, ...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Effect of different loads of treadmill exercise on Th1/Th2 cytokine balance in rat splenocytes
Publication date: Available online 24 May 2018Source: Journal of Applied BiomedicineAuthor(s): Zahra Gholamnezhad, Mohammad Hossein Boskabady, Mahmoud HosseiniAbstractThe effect of moderate and overtraining exercise on Th1/Th2 balance was evaluated in rat splenocytes. Male Wistar rats were divided into sedentary control (C), moderately trained (MT; V = 20 m/min, 30 min/day, 8 weeks), overtrained (OT; V = 25 m/min, 60 min/day, 11 weeks) and recovered after overtraining (OR) (OT plus 2 weeks recovery) groups. At the end of study, cell viability, proliferation, interleukin 4 (IL-4) and interferon-γ (IFN-γ) s...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
A proteomic glimpse into the oncogenesis of prostate cancer
Publication date: Available online 24 May 2018Source: Journal of Applied BiomedicineAuthor(s): Patrícia Borba Martiny, Diego Duarte Alcoba, Brasil Silva Neto, Paulo Costa Carvalho, Ilma Simoni BrumAbstractProstate cancer (PCa) is the second most frequent cancer in men worldwide. Distinguishing between the nonaggressive and aggressive forms of this disease is difficult, and a means to better characterize molecular patterns that could aid in diagnosis is urgently needed. Here, we compare the proteomic profiles of PCa and benign prostatic hyperplasia (BPH) in an effort to elucidate underlying mechanisms of oncogenesis. We co...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
This study aimed to ascertain antidiabetic potential of methanolic extract of Pseuduvaria macrophylla bark (PM) using streptozotocin-nicotinamide induced diabetic rat models. Various phytochemical and biochemical properties of the plant have been evaluated. The results showed that the extract has potentially normalized the elevated blood glucose levels by upregulating the insulin and C-peptide levels and alleviated oxidative stress by improving glutathione (GSH) and reducing lipid peroxidation (LPO) in the diabetic rats. In addition, PM has drastically downregulated the levels of pro-inflammatory cytokines and transforming...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways
ConclusionRAG may have clinical utility to decrease the dosage of 5-FU in colorectal cancer therapeutics.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Adipocytokines and new onset diabetes mellitus after transplantation
Publication date: Available online 31 May 2018Source: Journal of Applied BiomedicineAuthor(s): Dominika Goldmannová, Jaromíra Spurná, Ondřej Krystyník, Jan Schovánek, Lubica Cibičková, David Karásek, Josef ZadražilAbstractBackground and aimDiabetes mellitus is a very common metabolic disease with a rising incidence. It is one of the most serious comorbidities in renal transplant recipients. New-onset diabetes after renal transplantation (NODAT) is associated with poor graft function, higher rates of cardiovascular complications and a poor prognosis. Adipocytokines, synthetized by adipose tissue influence metaboli...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Berbamine protects the heart from isoproterenol induced myocardial infarction by modulating eNOS and iNOS expressions in rats
Publication date: Available online 7 June 2018Source: Journal of Applied BiomedicineAuthor(s): Saranya Sithuraj, Vijaya Padma ViswanadhaAbstractAimThe current study was designed to investigate the effect of berbamine (BBM) on isoproterenol (ISO) induced changes in cardiac marker enzymes, myocardial oxidative stress, lipid profile and expression of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) in male Wistar rats. Rats were pretreated with BBM (25 mg/kg) through intraperitoneal injection for 7 days followed by induction of myocardial infarction (MI) by subcutaneous injection of ISO (8...
Source: Journal of Applied Biomedicine - July 11, 2018 Category: Biotechnology Source Type: research
Influence of skin permeation enhancers on the transdermal delivery of palonosetron: An in vitro evaluation
This study reveals that the optimized transdermal system with propylene glycol as permeation enhancers can provide effective therapeutic level of palonosetron.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
NTPDase, 5′-nucleotidase and adenosine deaminase activities and purine levels in serum of sickle cell anemia patients
Publication date: Available online 26 December 2017Source: Journal of Applied BiomedicineAuthor(s): Lívia G. Castilhos, Stephen A. Adefegha, Pedro H. Doleski, Tatiana M.D. Bertoldo, Cesar Eduardo J. Moritz, Emerson A. Casali, Daniela B.R. LealAbstractSickle cell anemia (SCA) is a hereditary disorder that is characterized by tendency of hemoglobin molecules within the erythrocytes to polymerize under hypoxia conditions, deform the red cells, and promote vaso-occlusion and endothelial damage. This disease may be associated with the extracellular release of nucleotides, particularly ATP, ADP and adenosine into the circulatio...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
A survey on applying machine learning techniques for management of diseases
Publication date: Available online 19 January 2018Source: Journal of Applied BiomedicineAuthor(s): Enas M.F. El HoubyAbstractDuring the past years, the increase in scientific knowledge and the massive data production have caused an exponential growth in databases and repositories. Biomedical domain represents one of the rich data domains. An extensive amount of biomedical data is currently available, ranging from details of clinical symptoms to various types of biochemical data and outputs of imaging devices. Manually extracting biomedical patterns from data and transforming them into machine-understandable knowledge is a ...
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Effect of gender, age, diet and smoking status on the circadian rhythm of ascorbic acid (vitamin C) of healthy Indians
ConclusionThe present observations confirm a definite circadian rhythm in ascorbic acid concentrations with significant effects of age, diet and smoking status in clinical health. Mapping the circadian rhythm of serum ascorbic acid in health can help explore its role in different pathophysiological conditions as pre-disease conditions may be characterized by alterations in the circadian amplitude and/or phase before there is a change in mean value.Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
Oral melatonin administration improves the objective and subjective sleep quality, increases 6-sulfatoxymelatonin levels and total antioxidant capacity in patients with fibromyalgia
ConclusionThe daily intake of melatonin improved the sleep quality, increased the aMT6-s levels and the total antioxidant capacity in patients with fibromyalgia. (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 5, 2018 Category: Biotechnology Source Type: research
