Novel chromogenic bacteria characterized and their probable treatment options using herbal products and reagents to restrict biofilm formation
Publication date: Available online 24 August 2017 Source:Journal of Applied Biomedicine Author(s): Sarbani Ashe, Subhadarshani Agasti, Satish Lakkoji, Pradipta Ranjan Rauta, Harekrushna Sahoo, Monalisa Mishra, Bismita Nayak Among all oral diseases, teeth infection is a commonly encountered problem in dentistry with teeth blackening commonly seen in kids. One of the major causes of teeth blackening are the chromogenic bacteria which form biofilm in the teeth. So far there is no significant and safe treatment available for teeth blackening. The current study focuses on teeth blackening by chromogenic bacteria and va...
Source: Journal of Applied Biomedicine - August 24, 2017 Category: Biotechnology Source Type: research
RGD peptide doped polypyrrole film as a biomimetic electrode coating for impedimetric sensing of cell proliferation and cytotoxicity
Publication date: Available online 12 July 2017 Source:Journal of Applied Biomedicine Author(s): Yuan Li, Chao Yu A novel and facile in vitro cell sensing system has been developed with one-step electropolymerization of the conducting polypyrrole(PPy) polymer using RGD peptide as the sole dopant on an indium tin oxide (ITO) surface. The resulted RGD peptide-doped polypyrrole (PPy/RGD) composite film had a robust surface, in which PPy provided a biocompatible matrix for cell growth and a conducting interface for electrical detection, while the RGD peptide entrapped in the PPy matrix conferred the desired biomimetic prop...
Source: Journal of Applied Biomedicine - July 13, 2017 Category: Biotechnology Source Type: research
Segmentation and detection of physical activities during a sitting task in Parkinson ’s disease participants using multiple inertial sensors
Publication date: Available online 16 June 2017 Source:Journal of Applied Biomedicine Author(s): Sara Memar, Mehdi Delrobaei, Greydon Gilmore, Kenneth McIsaac, Mandar Jog Introduction The development of inertial sensors in motion capture systems enables precise measurement of motor symptoms in Parkinson’s disease (PD). The type of physical activities performed by the PD participants is an important factor to compute objective scores for specific motor symptoms of the disease. The goal of this study is to propose an approach to automatically detect the physical activities over a period time and segment the time sta...
Source: Journal of Applied Biomedicine - June 17, 2017 Category: Biotechnology Source Type: research
The role of keratinocytes in inflammation
Publication date: Available online 16 June 2017 Source:Journal of Applied Biomedicine Author(s): Jana Juráňová, Jana Franková, Jitka Ulrichová The epidermis is the external layer of the skin and is composed mainly of keratinocytes. Therefore, keratinocytes play an indispensable role as inherent constituents of the skin barrier in physical defenses against environmental threats. Keratinocytes also exert an active protective role against invasion by pathogens. This competency is of particular importance when physical defenses fail as a consequence of skin injury. During the inflammatory phase of healing, keratinocy...
Source: Journal of Applied Biomedicine - June 16, 2017 Category: Biotechnology Source Type: research
Neuroprotection and cognitive enhancement by treatment with γ-oryzanol in sporadic Alzheimer’s disease
Publication date: Available online 16 June 2017 Source:Journal of Applied Biomedicine Author(s): Abhishek B. Jha, Shital S. Panchal Sporadic Alzheimer’s disease is characterised by cognitive impairments and associated with cerebrometabolic anomaly and dementia which are burdensome for the old age population and their caregivers worldwide. A safe and effective treatment is essentially required for its prevention and cure. γ-Oryzanol (OZ) is reported for anti-oxidative, anti-inflammatory, anticancer, anti-hyperlipidemic, and anti-diabetic effects in various preclinical studies. In silico studies showed similar binding...
Source: Journal of Applied Biomedicine - June 16, 2017 Category: Biotechnology Source Type: research
Impact of hormonal changes on the semen quality and assisted reproductive outcomes in infertile men
In conclusion, the changes in the follicle-stimulating hormone, luteinizing hormone, and testosterone by changes in the sperm quality, and DNA damage may have the effects on assisted reproductive outcomes (e.g., low fertilization, poor zygote and embryo quality, and high miscarriage). Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - May 7, 2017 Category: Biotechnology Source Type: research
Design and drug-like properties of new 5-methoxysalicylaldehyde based hydrazones with anti-breast cancer activity
Publication date: Available online 7 May 2017 Source:Journal of Applied Biomedicine Author(s): Boryana Nikolova-Mladenova, Georgi Momekov, Darvin Ivanov, Adriana Bakalova Novel benzoylhydrazones were designed and synthesized by condensation of 5-methoxysalicylaldehyde and benzhydrazides with different substituents at 4th position. The structures of the new derivatives were confirmed by elemental and thermal analysis, mass, IR, 1H NMR and 13C NMR spectroscopy. The molecular properties of the compounds, important for drug pharmacokinetics and biodisposition in the human body, were assessed by the Lipinski's rule of fiv...
Source: Journal of Applied Biomedicine - May 7, 2017 Category: Biotechnology Source Type: research
Anticancer effect and enhancement of therapeutic potential of Vincristine by extract from aerial parts of Juniperus excelsa on pre-B acute lymphoblastic leukemia cell lines
Publication date: Available online 26 April 2017 Source:Journal of Applied Biomedicine Author(s): Mina Darvishi, Somayeh Esmaeili, Nasrin Dehghan-Nayeri, Pargol Mashati, Ahmad Gharehbaghian The natural products and conventional chemotherapeutic drugs combination can increase the efficacy of anticancer treatment through their potential synergistic effects and reduce its toxicity. The current study investigates the effect of methanolic extract from aerial parts of Juniperus excelsa on cell death activities induced by vincristine in acute lymphoblastic leukemia cells. Cytotoxic activity of J. excelsa extract and vincri...
Source: Journal of Applied Biomedicine - April 27, 2017 Category: Biotechnology Source Type: research
Effects of Shen-Fu injection on random skin flap survival in rats
Conclusion This study showed that intraperitoneally administered SFI significantly improved random skin flap survival in rats. (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
Hits and defeats of genome-wide association studies of atopy and asthma
Publication date: Available online 24 March 2017 Source:Journal of Applied Biomedicine Author(s): Hanna Danielewicz Atopy and asthma are complex conditions, recognised as outcomes in which both genes and environment play crucial role. Large number of disease associated loci have been identified within GWAS approach over last years and the knowledge of pathobiology of asthma and allergy has widened substantially. However still the results achieved are difficult to interpret. Most markers have no clear function on and expound small portion of heritability. The “missed heritability” could be hidden in the gene-by envir...
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
β-Cyclodextrin modified mesoporous silica nanoparticles as a nano-carrier: Response surface methodology to investigate and optimize loading and release processes for curcumin delivery
In this study, the novel [β-CD@PEGylated KIT-6] NPs nano-carrier was employed for CUR delivery successfully. The nano-DDS was characterized using different techniques such as X-ray powder diffraction (XRD), transmission and scanning electron microscopy (TEM and SEM), Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimeter (DSC), N2 adsorption–desorption measurement, and dynamic light scattering (DLS). In this study, first, the combination of central composite design (CCD) and response surface methodology (RSM) was used to achieve the optimal condition of the loading step with investigation of ...
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
Ameliorating effect of Curculigo orchoides on chromium(VI) induced oxidative stress via, modulation of cytokines, transcription factors and apoptotic genes
Publication date: Available online 7 April 2017 Source:Journal of Applied Biomedicine Author(s): Navya K., Phani Kumar G., Anilakumar K.R. The effect of hydro-alcoholic extract of Curculigo orchoides on hexavalent chromium (Cr VI) induced toxicity in rats was investigated. Sub-acute toxicity studies were performed by OECD guidelines. K2Cr2O7 (30mg/kg) was administered to all groups except control group for a period of 28days by oral gavage. Control group received distilled water; treatment groups received C. orchoides (25, 50 and 100mg/kg). Cr(VI) administration resulted in up-regulation of serum biochemical parameter...
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
Microbial synthesis of nanoparticles and their potential applications in biomedicine
This article highlights the green approach of nanomaterials synthesis using microbes and current status of their applications in biomedical field. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
IL-37 mediates the anti-tumor activity in non-small cell lung cancer through IL-6/STAT3 pathway
Publication date: Available online 24 April 2017 Source:Journal of Applied Biomedicine Author(s): Yan-Ming Deng, Hua Zhang, Jian-Miao Liang, Hai-Bing Xian, Ze-Cheng Chen, Yi-Cong Tang, Shuang Yang, Wei-Neng Feng The occurrence and development of lung cancer is closely related to inflammation. Thus, we conducted the present study to investigate the effects of IL-37 (Interleukin 37), a newly identified anti-inflammatory factor, on non-small cell lung cancer (NSCLC), which accounts for about 85% of all lung cancers. To address the function of IL-37 in NSCLC, we first evaluated IL-37 expression in the human NSCLC tis...
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
Ioduria and type 1 diabetes mellitus – Relationships to selected clinical markers of diabetes in adults
Conclusions: Iodine saturation levels in our study group were within the ICCIDD (WHO) recommendations for optimal/good saturation for the non-diabetic population, and patients with diabetic syndrome did not differ with respect to the chosen normal ioduria concentrations, i.e. 100 or 150μg/l. The question remains, however, whether past attempts to deal with iodine deficits in the Czech Republic are responsible for this satisfactory iodine status of the type 1 diabetic population, or if there are other factors involved. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - April 26, 2017 Category: Biotechnology Source Type: research
