β-Cyclodextrin modified mesoporous silica nanoparticles as a nano-carrier: Response surface methodology to investigate and optimize loading and release processes for curcumin delivery

In this study, the novel [β-CD@PEGylated KIT-6] NPs nano-carrier was employed for CUR delivery successfully. The nano-DDS was characterized using different techniques such as X-ray powder diffraction (XRD), transmission and scanning electron microscopy (TEM and SEM), Fourier transform infrared (FT-IR) spectroscopy, differential scanning calorimeter (DSC), N2 adsorption–desorption measurement, and dynamic light scattering (DLS). In this study, first, the combination of central composite design (CCD) and response surface methodology (RSM) was used to achieve the optimal condition of the loading step with investigation of two important factors: the loading time and the weight ratio of drug to nano-carrier. Maximum loading efficiency 88.55% was obtained at 43h of loading time and 1.22 of the weight ratio. Then CUR was loaded onto the nano-carrier at this optimal condition and its released was investigated by CCD-RSM. The maximum drug release was obtained at 5.16 of pH and 107h of release time. Graphical abstract
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research