Assessment of antioxidant, antimicrobial and anti-osteosarcoma potential of four traditionally used Indian medicinal plants
Publication date: Available online 25 October 2016 Source:Journal of Applied Biomedicine Author(s): Debasis Nayak, Sarbani Ashe, Pradipta Ranjan Rauta, Bismita Nayak In the present investigation Hibiscus rosa-sinensis (petals), Acorus calamus (rhizome), Moringa oleifera (leaves) and Cucurbita maxima (petals) were screened for their efficacy against osteosarcoma with elucidating a mechanism of their anticancer potentiality. The methanolic plant extracts revealed the presence of all major phytochemicals with quantitative analysis of flavonoids (98.15±2.02 to 12.34±0.57mg of RUE/g) and total phenolics (26.40±0.11 to ...
Source: Journal of Applied Biomedicine - October 28, 2016 Category: Biotechnology Source Type: research
Magnetocaloric effect for inducing hypothermia as new therapeutic strategy for stroke: A physical approach
This study allowed us to discuss about the use of new materials and strategies for further in vivo experiments. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - October 9, 2016 Category: Biotechnology Source Type: research
Examining the temporo-mandibular joint from a biotensegrity perspective: A change in thinking
Publication date: Available online 8 October 2016 Source:Journal of Applied Biomedicine Author(s): Graham Scarr, Helen Harrison The temporo-mandibular joint is a characteristic feature of mammalian development, and essential to mastication and speech, yet it causes more problems than any other joint in the body and remains the least understood. While it is generally accepted that the normal joint is loaded under compression, the problems and controversies surrounding this view remain unresolved and the disparity in opinion over its treatment continues. Although difficulties in the acquisition of reliable information ha...
Source: Journal of Applied Biomedicine - October 9, 2016 Category: Biotechnology Source Type: research
A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K305, K307) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice
Publication date: Available online 8 October 2016 Source:Journal of Applied Biomedicine Author(s): Jiri Kassa, Vendula Sepsova, Anna Horova, Kamil Musilek The reactivating and therapeutic efficacy of two newly developed oximes (K305, K307) was compared with the oxime K203 and trimedoxime using in vivo methods The study determining percentage of reactivation of tabun-inhibited acetylcholinesterase in the peripheral as well as central nervous system (diaphragm, brain) in tabun-poisoned rats showed that the reactivating efficacy of both newly developed oximes is lower compared to the reactivating efficacy of the oxime K...
Source: Journal of Applied Biomedicine - October 9, 2016 Category: Biotechnology Source Type: research
Exercise-induced epigenetic regulations in inflammatory related cells
Publication date: Available online 10 October 2016 Source:Journal of Applied Biomedicine Author(s): Małgorzata Zawadzka, Paweł Piotr Jagodziński Physical activity has been correlated with transient immune impairment. However, such activities lead to improvement in immunity rather than dysfunction. The major benefit of regular exercise is the reduction of low-grade inflammation which consequently prevents or attenuates metabolic diseases, such as atherosclerosis and type 2 diabetes, neurodegenerative disorders, cancer or even depression. As a major factor responsible for general improvements in the immune system, sci...
Source: Journal of Applied Biomedicine - October 9, 2016 Category: Biotechnology Source Type: research
Zinc supplementation modifies trace element status in exercised rats
Conclusions Beneficial effect of zinc supplementation in exercised organism may be associated not only with modulation of zinc status but regulation of other essential trace elements status and their biological effects. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - October 5, 2016 Category: Biotechnology Source Type: research
Evaluation of soman-induced extracranial histopathology in the context of clinical biochemistry, mitotic and apoptotic activity and morphometric analysis
Publication date: Available online 4 October 2016 Source:Journal of Applied Biomedicine Author(s): Jaroslav Pejchal, Jiří Kassa, Jan Misík, Jana Hatlapatková We aimed this study to evaluate histopathology of heart, lung, liver, kidney, small and large intestine in the context of clinical biochemistry, mitotic (intestine only) and apoptotic activity and morphometric analysis (intestine and lung only). Male Wistar rats were poisoned by soman (i.m., 52μgkg−1; 70% LD50). Samples were taken 1, 3 and 7 days following soman exposure. Biochemistry was evaluated in blood. Hematoxylin-eosin staining, Mallory's PTAH me...
Source: Journal of Applied Biomedicine - October 4, 2016 Category: Biotechnology Source Type: research
Deagglomeration and characterization of detonation nanodiamonds for biomedical applications
Publication date: Available online 4 October 2016 Source:Journal of Applied Biomedicine Author(s): Seidy Pedroso-Santana, Andrei Sarabia-Saínz, Noralvis Fleitas-Salazar, Karla Santacruz-Gómez, Monica Acosta-Elías, Martin Pedroza-Montero, Raul Riera Detonation nanodiamonds (DNDs) are usually small particles of 4–5nm, but in aqueous suspension, DNDs form agglomerates in sizes larger than 1μm. We propose the use of Bead Assisted Sonic Disintegration and a carboxylation procedure, to reduce DNDs aggregates sizes to approximately 100nm. High cost zirconium beads have been substituted by silica beads synthetized i...
Source: Journal of Applied Biomedicine - October 4, 2016 Category: Biotechnology Source Type: research
Lack of association between PBMC telomere length and endurance exercise
Publication date: Available online 1 October 2016 Source:Journal of Applied Biomedicine Author(s): Joshua Denham Telomeres are repetitive DNA located at the ends of chromosomes that preserve genomic stability. Excessive leukocyte telomere shortening is associated with cardio-metabolic disease and increased mortality risk. Although most studies indicate exercise training could attenuate leukocyte telomere attrition, data is somewhat equivocal. The inconsistencies could be partly explained by the different populations of leukocytes isolated for telomere length assessment. Accordingly, average peripheral blood mononuclear ...
Source: Journal of Applied Biomedicine - October 1, 2016 Category: Biotechnology Source Type: research
Modulation of HMG-CoA reductase and glutathione-linked enzymes and protection against pro-oxidant induced oxidative damage in colon (Caco-2) cells and rat colon homogenates by phenolic extracts from Shaddock (Citrus maxima) peels
This study sought to characterize the soluble free and bound phenolic compounds from shaddock (Citrus maxima) peels and investigate their effect on 3-hydroxy-methyl-3-glutaryl coenzyme A reductase (HMG-CoA reductase) and glutathione-linked enzymes in colon (Caco-2) cells. The radicals scavenging ability and the protective ability of the phenolic extracts against pro-oxidant induced oxidative damage in Caco-2 cells and rat colon homogenates were also investigated. The free phenolics were extracted with 80% acetone (v/v), while bound phenolics were extracted from the alkaline (NaOH) and acid (HCl) hydrolyzed residue with eth...
Source: Journal of Applied Biomedicine - September 21, 2016 Category: Biotechnology Source Type: research
Solid-state NMR study of discrete environments of bone mineral nanoparticles using phosphorus-31 relaxation
Publication date: Available online 26 August 2016 Source:Journal of Applied Biomedicine Author(s): Agnieszka Kaflak, Dariusz Chmielewski, Waclaw Kolodziejski Bone mineral nanoparticles, residing between collagenous fibres, contain a crystalline apatite core (CAC) covered by an amorphous hydrated surface layer (AHSL). The main objectives of this work were to characterize the nanoparticles of human bone mineral and their discrete CAC and AHSL regions and relate this information to bone diseases. This pilot study involved 18 postmenopausal women suffering from osteoarthritis together with osteoporosis or osteopenia. Trab...
Source: Journal of Applied Biomedicine - August 26, 2016 Category: Biotechnology Source Type: research
Colorimetric sensor based on bubble wrap and camera phone for glucose determination
Publication date: Available online 25 August 2016 Source:Journal of Applied Biomedicine Author(s): Pavla Martinkova, Miroslav Pohanka Glucose is a typical marker of diabetes mellitus but it corresponds also with metabolic syndrome, immune disorders and some types of poisoning. Hence fast, low cost and simple method for its determination is required. Bubble wrap, cheap and available material, was used for immobilization of glucose oxidase (GOx) and peroxidase (POx), the enzymes necessary for colorimetric determination of glucose. Method is based on reaction of enzymes (immobilized in sol-gel membrane inside the bubbles)...
Source: Journal of Applied Biomedicine - August 25, 2016 Category: Biotechnology Source Type: research
Investigation of betahistine dihydrochloride biocompatibility and nasal permeability in vitro
Publication date: Available online 27 July 2016 Source:Journal of Applied Biomedicine Author(s): Bissera Pilicheva, Milena Draganova-Filipova, Plamen Zagorchev, Margarita Kassarova xxx. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 27, 2016 Category: Biotechnology Source Type: research
Evaluation of physicochemical and stability properties of human growth hormone upon enzymatic PEGylation
Conclusion PEGylation changed the physicochemical properties of hGH and also enhanced the stability of the protein. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 25, 2016 Category: Biotechnology Source Type: research
Effects of fullerenol nanoparticles and amifostine on radiation-induced tissue damages: Histopathological analysis
Publication date: Available online 25 July 2016 Source:Journal of Applied Biomedicine Author(s): Jacevic Vesna, Jovic Danica, Kuca Kamil, Dragojevic-Simic Viktorija, Dobric Silva, Trajkovic Sanja, Borisev Ivana, Segrt Zoran, Milovanovic Zoran, Bokonjic Dubravko, Djordjevic Aleksandar Fullerenol C60(OH)24 nanoparticles (FNP) are promising radioprotectors in prevention of early and late ionizing radiation injury. The aim of this study was to compare the efficacy of FNP and amifostine (AMI) in protection of rats exposed to whole-body X-ray irradiation (7 or 8Gy). Both compounds (FNP, 100mg/kg ip; AMI...
Source: Journal of Applied Biomedicine - July 25, 2016 Category: Biotechnology Source Type: research
