Carnosol ameliorates monosodium iodoacetate-induced osteoarthritis by targeting NF- κB and Nrf-2 in primary rat chondrocytes
This study demonstrates that, carnosol might act as potent antioxidant and regulate MIA-induced oxidative stress, NF-κB signaling and programmed cell death by up regulating the Nrf-2 levels. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 25, 2016 Category: Biotechnology Source Type: research
Evaluation of mucoadhesive oral films containing nystatin
Publication date: Available online 21 July 2016 Source:Journal of Applied Biomedicine Author(s): Markéta GajdoÅ¡ová, David Vetchý, Petr Doležel, Jan Gajdziok, Hana Landová, Jan MuselÃk, Jiřà Zeman, ZdenÄ›k Knotek, Karel Hauptman, VladimÃr Jekl The aim of the presented research was the preparation and in vitro and in vivo evaluation of mucoadhesive oral films containing nystatin. Multivariate data analysis was used to evaluate an innovative approach, in which a combination of different mucoadhesive polymers was employed. The purpose of this was to assess the effects of such a combination on ...
Source: Journal of Applied Biomedicine - July 21, 2016 Category: Biotechnology Source Type: research
Self-assembly of carrageenin –CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery
Publication date: July 2015 Source:Journal of Applied Biomedicine, Volume 13, Issue 3 Author(s): Maximiliano L. Cacicedo, Karina Cesca, Valeria E. Bosio, Luismar M. Porto, Guillermo R. Castro Stereospecific nucleation of mesoporous hybrid microspheres composed of CaCO3 and carrageenan was appended to one side of bacterial cellulose membrane synthesized in static cultures of Gluconacetobacter hansenii to develop an implantable drug delivery device. The synthesis of the hybrid microparticles proceeds by self-assembly mechanism in the presence of calcium and contains tailorable amounts of doxorubicin. However, i...
Source: Journal of Applied Biomedicine - July 19, 2016 Category: Biotechnology Source Type: research
Enhanced hypoxic tolerance by Seabuckthorn is due to upregulation of HIF-1 α and attenuation of ER stress
Publication date: February 2016 Source:Journal of Applied Biomedicine, Volume 14, Issue 1 Author(s): Kanika Jain, Geetha Suryakumar, Rajendra Prasad, Lilly Ganju, Shashi Bala Singh An imbalance in the redox homeostasis causes activation of multifaceted signaling responses which may be protective or deleterious. Amelioration of oxidative stress is one of the major modes of action of herbal supplements like Seabuckthorn (SBT). While the antioxidant potential of SBT is known, investigations into its effect on stress inducible signaling cascades are in progress. Here, we examine the impact of SBT on hypoxic toler...
Source: Journal of Applied Biomedicine - July 19, 2016 Category: Biotechnology Source Type: research
Quasi emulsion spherical crystallization technique based environmentally responsive Tulsion ® (pH dependent) microspheres for colon specific delivery
Publication date: April 2016 Source:Journal of Applied Biomedicine, Volume 14, Issue 2 Author(s): Ashish Jain, Ankit Jain, Abhishek Jain, Anki Jain pH-dependent sustained-release Tulsion® microspheres bearing clarithromycin were prepared using quasi-emulsion solvent diffusion method with thermocoat L 30 D 55 as a release retardant. Both, clarithromycin and thermocoat L 30 D 55, were found to be non-hemolytic during in vitro toxicity assay against human red blood cells. Ratiometric optimization of different solvents using phase diagrams was performed on amount of good solvent, bridging liquid, dispersing liquid...
Source: Journal of Applied Biomedicine - July 19, 2016 Category: Biotechnology Source Type: research
Cell wall distracting anti-Methicillin-resistant Staphylococcus aureus compound PVI331 from a marine sponge associated Streptomyces
This study highlighted the anti-MRSA property of Streptomyces albus ICN33 from a marine sponge. Graphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - July 13, 2016 Category: Biotechnology Source Type: research
Combination of the essential oil constituents α-pinene and β-caryophyllene as a potentiator of trypanocidal action on Trypanosoma evansi
Publication date: Available online 12 July 2016 Source:Journal of Applied Biomedicine Author(s): Renata G. Amaral, Matheus D. Baldissera, Thirssa H. Grando, Jéssica C.M. Couto, Christopher P. Posser, Andiara P. Ramos, Michele R. Sagrillo, Rodrigo A. Vaucher, Aleksandro S. Da Silva, Ana P. Becker, Silvia G. Monteiro The effect of the combination of α-pinene and β-caryophyllene on the proliferation of the Trypanosoma evansi was analyzed. These compounds were added individually and in combination at different concentrations to T. evansi cultures, and the in vivo study used mice of 1.0 and 1.5mLkgâ...
Source: Journal of Applied Biomedicine - July 13, 2016 Category: Biotechnology Source Type: research
Effect of bergenin on hepatic glucose metabolism and insulin signaling in C57BL/6J mice with high fat-diet induced type 2 diabetes
Publication date: Available online 16 April 2016 Source:Journal of Applied Biomedicine Author(s): Sagadevan Ambika, Ramaligam SaravananGraphical abstract (Source: Journal of Applied Biomedicine)
Source: Journal of Applied Biomedicine - April 25, 2016 Category: Biotechnology Source Type: research
Fluoride, aluminum, and aluminofluoride complexes in pathogenesis of the autism spectrum disorders: A possible role of immunoexcitotoxicity
Publication date: Available online 19 April 2016 Source:Journal of Applied Biomedicine Author(s): Anna Strunecka, Russell L. Blaylock, Otakar Strunecky Autism spectrum disorders (ASD) are characterized by impairments in social interaction and communication along with stereotyped patterns of behaviors. Over the past several decades, the prevalence of ASD has increased dramatically. ASD are highly multifactorial, with many risk factors acting together. Our review suggests that most risk factors are connected to immunoexcitotoxicity. Fluoride exposure is common as a result of the artificial fluoridation of drinking ...
Source: Journal of Applied Biomedicine - April 25, 2016 Category: Biotechnology Source Type: research
Antitumoral activity of novel 1,4-naphthoquinone derivative involves L-type calcium channel activation in human colorectal cancer cell line
Publication date: Available online 7 April 2016 Source:Journal of Applied Biomedicine Author(s): Juan Carlos Ramos Gonçalves, Tangbadioa Herve Coulidiati, André LuÃs Monteiro, LaÃs Campos Teixeira de Carvalho-Gonçalves, Wagner de Oliveira Valença, Ronaldo Nascimento de Oliveira, Celso de Amorim Camara, Demetrius Antônio Machado de Araújo Colorectal cancer (CRC) is an important public health problem estimated as the third most commonly diagnosed cancer worldwide, with over 1.2million new cases and 608,700 deaths per year. Previous study reported the involvement of ion channels to the development ...
Source: Journal of Applied Biomedicine - April 7, 2016 Category: Biotechnology Source Type: research
Resolving the problems and controversies surrounding temporo-mandibular mechanics
Publication date: Available online 8 April 2016 Source:Journal of Applied Biomedicine Author(s): Graham Scarr, Helen Harrison The temporo-mandibular joint causes more problems than any other in the body and is the least understood with the high incidence of associated symptomatology remaining a major cause for concern. This lack of knowledge is partly due to the difficulties in acquiring information as it is not easy to access and practical and ethical constraints have ensured the almost complete absence of reliable in vivo data on joint loading and muscle forces. Whilst the issue of joint compression was debated t...
Source: Journal of Applied Biomedicine - April 7, 2016 Category: Biotechnology Source Type: research
Plant-mediated gold nanoparticles by Dracocephalum kotschyi as anticholinesterase agent: Synthesis, characterization, and evaluation of anticancer and antibacterial activity
In this study, the gold nanoparticles using Dracocephalum kotschyi leaf extract (d-GNPs) were synthesized and characterized by TEM-SEAD, SEM-EDAX, XRD, Zeta potential, DLS, and FT-IR analysis. TEM photograph showed spherical morphologies with an average size of 11nm. SEAD pattern authorized fcc structure of these particles. The average zeta value of −29.3mV revealed the surface charge of green synthesized GNPs. We studied the influence of different parameters such as reaction temperature, contact time, and pH on the synthesis of d-GNPs by UV–vis spectroscopy. Moreover, the obtained nanoparticles were evaluated regardin...
Source: Journal of Applied Biomedicine - March 20, 2016 Category: Biotechnology Source Type: research
Speech and language impairments in dementia
Publication date: Available online 27 February 2016 Source:Journal of Applied Biomedicine Author(s): Blanka Klimova, Kamil Kuca The current demographic trend is dramatically changing; particularly the number of older people is rising. This trend of older population causes an increase of aging diseases such as dementia. At present the most frequent type of dementia is Alzheimer's disease, the second most frequent type is vascular dementia, and the third one is dementia with Lewy bodies. These are then followed by Parkinson's disease dementia, frontotemporal dementia/degeneration, and mixed dementia. The purpose of t...
Source: Journal of Applied Biomedicine - March 9, 2016 Category: Biotechnology Source Type: research
Speech and language impairments in dementia – a mini review
Publication date: Available online 27 February 2016 Source:Journal of Applied Biomedicine Author(s): Blanka Klimova, Kamil Kuca The current demographic trend is dramatically changing; particularly the number of older people is rising. This trend of older population causes an increase of aging diseases such as dementia. At present the most frequent type of dementia is Alzheimer's disease, the second most frequent type is vascular dementia, and the third one is dementia with Lewy bodies. These are then followed by Parkinson's disease dementia, frontotemporal dementia/degeneration, and mixed dementia. The purpose of t...
Source: Journal of Applied Biomedicine - February 28, 2016 Category: Biotechnology Source Type: research
Caspase dependent apoptotic activity of Rubus fairholmianus Gard. on MCF-7 human breast cancer cell lines
This study investigated the antiproliferative and apoptosis inducing ability of Rubus fairholmianus root acetone (RFRA) on MCF-7 cells. RFRA treatments showed an increase in the in vivo antioxidant levels such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH) in mice. The extract showed significant antitumour activity with 76.57% increase in life span of ascites tumour bearing mice and 1.94cm3 reductions in solid tumour volume at 250mg/kg. The cytotoxicity spectrum analysis indicated that RFRA is a potent cytocidal agent with varying levels of toxicity (IC50: 57.14–29.36μg...
Source: Journal of Applied Biomedicine - February 21, 2016 Category: Biotechnology Source Type: research
