Antitumoral activity of novel 1,4-naphthoquinone derivative involves L-type calcium channel activation in human colorectal cancer cell line

Publication date: Available online 7 April 2016 Source:Journal of Applied Biomedicine Author(s): Juan Carlos Ramos Gonçalves, Tangbadioa Herve Coulidiati, André Luís Monteiro, Laís Campos Teixeira de Carvalho-Gonçalves, Wagner de Oliveira Valença, Ronaldo Nascimento de Oliveira, Celso de Amorim Camara, Demetrius Antônio Machado de Araújo Colorectal cancer (CRC) is an important public health problem estimated as the third most commonly diagnosed cancer worldwide, with over 1.2million new cases and 608,700 deaths per year. Previous study reported the involvement of ion channels to the development of many diseases including cancers. The calcium ion (Ca2+) is an important signaling factor that modulates numerous cellular processes in cancer cells, such as apoptosis, metastasis, cell division and proliferation. The high expression levels of certain Ca2+-permeable ion channels in tumor cells, like CRC cell line HT-29, make them interesting targets for diagnosis and more specifically chemotherapeutics. Naphthoquinones are compounds present in different families of plants and considered privileged structures in medicinal chemistry due to their activities as potent inhibitors of human cancer growth. Due to their high toxicity to normal cells, a structure-modification of the naphthoquinone nucleus are required in order to permit its clinical use in a near future. Therefore, the objective of this study was to evaluate the cytotoxicity and selectiveness of nov...
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research