Overt hypothyroidism is associated with blood inflammatory biomarkers dependent of lipid profile

Publication date: Available online 21 October 2015 Source:Journal of Applied Biomedicine Author(s): Adriana Santi, Ivana Beatrice Mânica da Cruz, Vania Lucia Loro, Marta Maria Medeiros Frescura Duarte, Fernanda Barbisan, Thiago Duarte, Anahy Gabriela Pasa To investigate the association between inflammatory biomarkers and overt hypothyroidism (OH). We measured inflammatory cytokines, interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) as well as cell-free DNA (cf-DNA) levels in 40 OH patients and 40 healthy controls. Total cholesterol, high and low density lipoprotein subfractions, triglyceride, fibrinogen, and D-dimer were recorded. Increased inflammatory profile was evidenced through significant elevations in the concentrations of all cytokines and cf-DNA levels in the OH group. Lipids and prothrombotic markers were also increased in hypothyroid subjects. A significant association between the inflammatory cytokines and lipid profile was observed. A multivariate analysis showed that this result was independent of the sex, age and BMI status of the subjects. Hypothyroidism is associated with proinflammatory state. Lipid abnormalities have a stronger influence on inflammation, increasing cardiovascular risk and atherosclerosis development in hypothyroidism. Graphical abstract
Source: Journal of Applied Biomedicine - Category: Biotechnology Source Type: research